Thilo S Lange Selected Research

Ovarian Neoplasms (Ovarian Cancer)

1/2014	HE4 (WFDC2) gene overexpression promotes ovarian tumor growth.
11/2013	PT19c, Another Nonhypercalcemic Vitamin D2 Derivative, Demonstrates Antitumor Efficacy in Epithelial Ovarian and Endometrial Cancer Models.
4/2012	Tetrathiomolybdate sensitizes ovarian cancer cells to anticancer drugs doxorubicin, fenretinide, 5-fluorouracil and mitomycin C.
1/2012	Cytotoxic properties of Adamantyl isothiocyanate and potential in vivo metabolite adamantyl-N-acetylcystein in gynecological cancer cells.
1/2012	Efficacy of a non-hypercalcemic vitamin-D2 derived anti-cancer agent (MT19c) and inhibition of fatty acid synthesis in an ovarian cancer xenograft model.
1/2012	Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells.
11/2011	Evaluation of the first Ergocalciferol-derived, non hypercalcemic anti-cancer agent MT19c in ovarian cancer SKOV-3 cell lines.
2/2011	A coumarin derivative (RKS262) inhibits cell-cycle progression, causes pro-apoptotic signaling and cytotoxicity in ovarian cancer cells.
10/2010	Effect of a vitamin D(3) derivative (B3CD) with postulated anti-cancer activity in an ovarian cancer animal model.
8/2010	Chemotherapeutic effect of calcidiol derivative B3CD in a neuroblastoma xenograft model.

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Thilo S Lange Research Topics

Disease

14	Ovarian Neoplasms (Ovarian Cancer) 01/2014 - 05/2008
13	Neoplasms (Cancer) 01/2014 - 02/2009
7	Neuroblastoma 01/2012 - 10/2007
5	Endometrial Neoplasms (Endometrial Cancer) 11/2013 - 07/2011
3	Hypercalcemia (Milk Alkali Syndrome) 11/2013 - 11/2011
1	Carcinogenesis 01/2014
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 02/2011
1	Leukemia 02/2011
1	Body Weight (Weight, Body) 09/2009
1	Prostatic Neoplasms (Prostate Cancer) 05/2008

Drug/Important Bio-Agent (IBA)

4	PlatinumIBA 10/2010 - 05/2008
3	Ergocalciferols (Ergocalciferol)FDA LinkGeneric 11/2013 - 11/2011
3	Vitamin D FDA LinkGeneric 11/2013 - 11/2011
3	CopperIBA 04/2012 - 09/2009
3	p38 Mitogen-Activated Protein KinasesIBA 04/2012 - 08/2010
3	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2012 - 02/2010
3	Iron(III)-salopheneIBA 04/2011 - 05/2008
3	Calcifediol (Calcidiol)FDA Link 10/2010 - 10/2007
2	Cisplatin (Platino)FDA LinkGeneric 01/2014 - 02/2011
2	Doxorubicin (Adriamycin)FDA LinkGeneric 04/2012 - 07/2011
2	Fluorouracil (Carac)FDA LinkGeneric 04/2012 - 02/2011
2	AntioxidantsIBA 01/2012 - 07/2011
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2012 - 02/2011
2	Cytotoxins (Cytolysins)IBA 04/2011 - 08/2010
2	Cholecalciferol (Vitamin D3)FDA Link 10/2010 - 10/2007
2	IronIBA 02/2010 - 09/2009
2	Organometallic CompoundsIBA 09/2009 - 05/2008
2	7-methyl-indole ethyl isothiocyanateIBA 05/2008 - 11/2007
2	ethyl isothiocyanateIBA 05/2008 - 11/2007
2	indoleIBA 05/2008 - 11/2007
1	Proteins (Proteins, Gene)FDA Link 01/2014
1	OligonucleotidesIBA 01/2014
1	WAP Four-Disulfide Core Domain Protein 2IBA 01/2014
1	abietyl-isothiocyanateIBA 08/2012
1	tetrathiomolybdate (ammonium tetrathiomolybdate)IBA 04/2012
1	CaspasesIBA 04/2012
1	FenretinideIBA 04/2012
1	Mitomycin (Mitomycin-C)FDA LinkGeneric 04/2012
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2012
1	Fatty Acid Synthases (Fatty Acid Synthase)IBA 01/2012
1	adamantyl isothiocyanateIBA 01/2012
1	proanthocyanidinIBA 01/2012
1	Proanthocyanidins (Procyanidins)IBA 01/2012
1	adamantyl-N-acetylcysteinIBA 01/2012
1	Messenger RNA (mRNA)IBA 01/2012
1	Calcitriol (Calcijex)FDA LinkGeneric 11/2011
1	Insulin Receptor Substrate ProteinsIBA 11/2011
1	RKS 262IBA 02/2011
1	sapacitabineIBA 02/2011
1	CoumarinsIBA 02/2011
1	NifurtimoxIBA 02/2011
1	Bromodeoxyuridine (BrdU)IBA 10/2010
1	AntibodiesIBA 08/2010
1	Epidermal Growth Factor (EGF)IBA 08/2010
1	Chelating AgentsIBA 02/2010
1	ChromatinIBA 02/2010
1	Deferoxamine (Desferal)FDA LinkGeneric 02/2010
1	MetalsIBA 02/2010
1	ManganeseIBA 09/2009
1	CobaltIBA 09/2009
1	Mitogen-Activated Protein KinasesIBA 02/2009
1	isothiocyanic acidIBA 02/2009
1	IsothiocyanatesIBA 11/2007

Therapy/Procedure

4	Therapeutics 11/2013 - 08/2010
1	Intraperitoneal Injections 09/2009
1	Aftercare (After-Treatment) 05/2008