Andrew L Kung Selected Research

Hypoxia (Hypoxemia)

1/2016	The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth.
6/2012	Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features.
2/2012	Anti-inflammatory properties of histone deacetylase inhibitors: a mechanistic study.
8/2009	HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice.
5/2009	Desferroxamine infusion increases cerebral blood flow: a potential association with hypoxia-inducible factor-1.
3/2009	Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis.
1/2009	Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia.
7/2005	A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas.
7/2004	Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway.
7/2003	Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2.

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Andrew L Kung Research Topics

Disease

99	Neoplasms (Cancer) 05/2024 - 11/2003
21	Leukemia 02/2024 - 02/2003
11	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 02/2024 - 02/2005
11	Multiple Myeloma 10/2017 - 03/2004
10	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 02/2024 - 03/2011
10	Hypoxia (Hypoxemia) 01/2016 - 07/2003
9	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2018 - 07/2007
9	Glioblastoma (Glioblastoma Multiforme) 05/2015 - 11/2003
8	Ewing Sarcoma (Sarcoma, Ewing) 01/2021 - 06/2006
8	Glioma (Gliomas) 01/2020 - 02/2006
7	Hematologic Neoplasms (Hematological Malignancy) 01/2017 - 03/2004
6	Neuroblastoma 01/2023 - 07/2008
6	Breast Neoplasms (Breast Cancer) 08/2021 - 12/2006
5	Carcinoma (Carcinomatosis) 10/2018 - 04/2011
4	Sarcoma (Soft Tissue Sarcoma) 05/2024 - 12/2018
4	Rhabdoid Tumor (Rhabdoid Tumors) 05/2024 - 11/2017
4	Lung Neoplasms (Lung Cancer) 10/2018 - 03/2012
4	Inflammation (Inflammations) 06/2015 - 09/2012
4	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 05/2010 - 02/2005
3	Graft vs Host Disease (Graft-Versus-Host Disease) 02/2024 - 03/2015
3	Neoplasm Metastasis (Metastasis) 01/2023 - 06/2012
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2014 - 08/2009
3	Endometriosis 07/2013 - 06/2006
3	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 10/2012 - 12/2006
3	Melanoma (Melanoma, Malignant) 10/2011 - 06/2006
3	Clear Cell Sarcoma 10/2011 - 06/2006
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2022 - 04/2012
2	Secretory breast carcinoma 01/2018 - 01/2017
2	Medulloblastoma 11/2017 - 11/2003
2	Viremia 01/2016 - 11/2015
2	Liposarcoma 09/2014 - 05/2006
2	Adenocarcinoma of Lung 03/2014 - 12/2010
2	Genetic Translocation (Chromosomal Translocation) 04/2012 - 06/2006

Drug/Important Bio-Agent (IBA)

28	Proteins (Proteins, Gene)FDA Link 12/2023 - 11/2003
10	Phosphotransferases (Kinase)IBA 05/2024 - 03/2004
7	Bortezomib (Velcade)FDA Link 01/2020 - 02/2006
7	Oncogene Proteins (Oncogene Protein)IBA 10/2018 - 04/2007
6	Biomarkers (Surrogate Marker)IBA 02/2024 - 05/2006
6	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 05/2013 - 03/2004
5	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 03/2012
5	Histone Deacetylase InhibitorsIBA 05/2015 - 07/2008
5	Transcription Factors (Transcription Factor)IBA 02/2012 - 07/2003
4	RNA (Ribonucleic Acid)IBA 01/2018 - 10/2015
4	EnzymesIBA 01/2016 - 04/2009
4	Small Interfering RNA (siRNA)IBA 09/2014 - 05/2013
4	LigandsIBA 07/2012 - 12/2005
4	LuciferasesIBA 03/2012 - 02/2006
3	tazemetostatIBA 05/2024 - 12/2023
3	Peptides (Polypeptides)IBA 12/2023 - 03/2004
3	Antineoplastic Agents (Antineoplastics)IBA 01/2023 - 02/2006
3	Exportin 1 ProteinIBA 11/2022 - 05/2015
3	selinexorIBA 01/2020 - 04/2013
3	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 02/2017 - 04/2014
3	Tyrosine (L-Tyrosine)FDA Link 05/2013 - 07/2007
3	nilotinib FDA Link 10/2012 - 03/2007
3	Histone Deacetylases (Histone Deacetylase)IBA 03/2012 - 07/2008
3	Hypoxia-Inducible Factor 1IBA 10/2011 - 01/2009
3	Lysine (L-Lysine)FDA Link 07/2011 - 11/2008
3	Histones (Histone)IBA 07/2011 - 11/2008
3	Imatinib Mesylate (Gleevec)FDA Link 04/2010 - 03/2007
3	plerixafor FDA Link 04/2009 - 11/2003
3	midostaurinIBA 12/2008 - 02/2003
2	TransposasesIBA 05/2024 - 11/2017
2	Monoclonal AntibodiesIBA 02/2024 - 05/2014
2	WT161IBA 08/2021 - 10/2017
2	Growth Factor ReceptorsIBA 08/2021 - 10/2017
2	ChromatinIBA 01/2021 - 10/2018
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2021 - 02/2003
2	Proteasome InhibitorsIBA 01/2020 - 02/2006
2	Drug CombinationsIBA 02/2017 - 07/2007
2	Everolimus FDA Link 02/2017 - 12/2006
2	ribociclibIBA 02/2017 - 09/2014
2	Dexamethasone (Maxidex)FDA LinkGeneric 02/2017 - 04/2012
2	Cyclin D3IBA 02/2017 - 10/2012
2	Doxorubicin (Adriamycin)FDA LinkGeneric 02/2017 - 04/2012
2	Tacrolimus (Prograf)FDA LinkGeneric 05/2016 - 03/2015
2	LuciferinsIBA 01/2015 - 02/2006
2	Firefly LuciferasesIBA 01/2015 - 02/2006
2	Adenosine Triphosphate (ATP)IBA 09/2014 - 05/2010
2	Anaplastic Lymphoma KinaseIBA 09/2014 - 12/2010
2	CrizotinibIBA 09/2014 - 03/2014
2	NVP-TAE684IBA 03/2014 - 12/2010
2	Deoxyglucose (2 Deoxy D glucose)IBA 02/2014 - 10/2012
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 11/2013 - 12/2006
2	10,10'-dimethyl-9,9'-biacridinium (Lucigenin)IBA 08/2013 - 09/2012
2	LuminolIBA 08/2013 - 09/2012
2	Proteasome Endopeptidase Complex (Proteasome)IBA 08/2013 - 05/2009
2	Vascular Endothelial Growth Factor CIBA 07/2013 - 10/2011
2	Messenger RNA (mRNA)IBA 07/2013 - 01/2009
2	CateninsIBA 06/2013 - 08/2012
2	Cadherins (E-Cadherin)IBA 06/2012 - 03/2009
2	CREB-Binding ProteinIBA 04/2012 - 07/2003
2	Vorinostat FDA Link 02/2012 - 04/2011
2	Microphthalmia-Associated Transcription FactorIBA 10/2011 - 08/2008
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 08/2011 - 09/2008

Therapy/Procedure

58	Therapeutics 05/2024 - 03/2004
12	Drug Therapy (Chemotherapy) 02/2024 - 03/2004
6	Cell Transplantation 02/2024 - 03/2015
3	Precision Medicine 01/2018 - 10/2016
3	Radiotherapy 06/2012 - 08/2011