Damijan Knez Selected Research

Enzymes

1/2022	Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy.
1/2022	ProBiS-Dock: A Hybrid Multitemplate Homology Flexible Docking Algorithm Enabled by Protein Binding Site Comparison.
1/2021	Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease.
1/2017	Dual inhibitors of cholinesterases and monoamine oxidases for Alzheimer's disease.
8/2016	Synthesis and preliminary biological evaluations of (+)-isocampholenic acid-derived amides.

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Damijan Knez Research Topics

Disease

25	Alzheimer Disease (Alzheimer's Disease) 05/2024 - 08/2015
7	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2023 - 08/2015
6	Neoplasms (Cancer) 02/2022 - 01/2017
2	Parkinson Disease (Parkinson's Disease) 05/2023 - 05/2022
2	Neuroblastoma 01/2022 - 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 11/2022
1	Stroke (Strokes) 08/2022
1	Glioblastoma (Glioblastoma Multiforme) 02/2022
1	Glioma (Gliomas) 02/2022
1	Breast Neoplasms (Breast Cancer) 01/2022
1	Pathologic Processes 05/2020
1	Prostatic Neoplasms (Prostate Cancer) 05/2020
1	Central Nervous System Diseases (CNS Diseases) 01/2020
1	Dementia (Dementias) 11/2018
1	Bacterial Infections (Bacterial Infection) 08/2016

Drug/Important Bio-Agent (IBA)

8	ButyrylcholinesteraseIBA 05/2023 - 01/2017
7	LigandsIBA 05/2023 - 11/2016
5	Amyloid (Amyloid Fibrils)IBA 05/2024 - 01/2018
5	Cholinesterases (Cholinesterase)IBA 05/2023 - 03/2016
5	AntioxidantsIBA 08/2022 - 05/2016
5	EnzymesIBA 01/2022 - 08/2016
4	Cholinergic Agents (Cholinergics)IBA 11/2022 - 12/2016
4	CathepsinsIBA 02/2022 - 01/2017
4	Cysteine (L-Cysteine)FDA Link 02/2022 - 01/2017
3	CarboxypeptidasesIBA 02/2022 - 01/2017
3	Monoamine Oxidase (MAO)IBA 01/2022 - 01/2017
2	Oxidoreductases (Dehydrogenase)IBA 05/2023 - 01/2017
2	Proteins (Proteins, Gene)FDA Link 01/2023 - 11/2022
2	Cathepsin BIBA 01/2022 - 01/2018
2	Tryptophan (L-Tryptophan)FDA Link 01/2022 - 03/2019
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 11/2016 - 05/2016
1	Fluorescent Dyes (Fluorescent Probes)IBA 05/2024
1	AcetylcholinesteraseIBA 05/2023
1	Free Radical ScavengersIBA 05/2023
1	Chelating AgentsIBA 05/2023
1	Oxidopamine (6 Hydroxydopamine)IBA 05/2023
1	Trace Elements (Biometals)IBA 05/2023
1	2-(N-cyclohexylamino)ethanesulfonic acid (CHES)IBA 05/2023
1	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2023
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2023
1	IonsIBA 11/2022
1	CopperIBA 11/2022
1	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2022
1	nitronesIBA 08/2022
1	Tissue Plasminogen Activator (Alteplase)FDA Link 08/2022
1	Phosphopyruvate Hydratase (Enolase)IBA 02/2022
1	DioxinsIBA 01/2022
1	TriazolesIBA 01/2022
1	Protease Inhibitors (Protease Inhibitor)IBA 01/2022
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 01/2022
1	KynurenineIBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	IndazolesIBA 01/2021
1	Antiparkinson Agents (Antiparkinsonian Agents)IBA 01/2021
1	MetalsIBA 02/2020
1	Protein Isoforms (Isoforms)IBA 01/2020
1	Scopolamine (Hyoscine)FDA Link 11/2018
1	nitroxolineIBA 01/2018
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2018
1	CollagenIBA 01/2018
1	tau Proteins (tau Protein)IBA 01/2018
1	Peptide Hydrolases (Proteases)FDA Link 01/2017
1	serotonin 6 receptorIBA 11/2016
1	AmidesIBA 08/2016
1	Amyloid beta-PeptidesIBA 03/2016

Therapy/Procedure

12	Therapeutics 05/2023 - 08/2015