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Susan J Kelly Selected Research

Pegloticase

3/2014Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients.
8/2010Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo.
3/2007Pharmacokinetics and pharmacodynamics of intravenous PEGylated recombinant mammalian urate oxidase in patients with refractory gout.
1/2006Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase.
5/2001Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase.

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Susan J Kelly Research Topics

Disease

5Gout
03/2014 - 05/2001
2Hyperuricemia
03/2014 - 01/2006
1Deficiency Diseases (Deficiency Disease)
10/2017
1Vasculitis (Vasculitides)
10/2016
1Pure Red-Cell Aplasia
10/2016
1GATA2 Deficiency
01/2016
1Schmid-Fraccaro syndrome
03/2014
1Osteoarthritis
02/2011
1Knee Osteoarthritis
02/2011
1Hypersensitivity (Allergy)
03/2007
1Diabetes Insipidus
05/2001

Drug/Important Bio-Agent (IBA)

5Urate Oxidase (Uricase)IBA
03/2014 - 05/2001
5PegloticaseFDA Link
03/2014 - 05/2001
5Uric Acid (Urate)IBA
02/2011 - 05/2001
4Adenosine DeaminaseIBA
10/2017 - 03/2014
2Ethylene Glycol (Monoethylene Glycol)IBA
01/2006 - 05/2001
1Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric
03/2014
1Interleukin-18 (Interleukin 18)IBA
02/2011
1InflammasomesIBA
02/2011
1Proteins (Proteins, Gene)FDA Link
08/2010
1F2-Isoprostanes (F2 Isoprostanes)IBA
08/2010
1LipidsIBA
08/2010
1Arachidonic Acid (Vitamin F)IBA
08/2010
1AntioxidantsIBA
08/2010
1Immunoglobulin G (IgG)IBA
03/2007
1EnzymesIBA
03/2007
1AntibodiesIBA
03/2007

Therapy/Procedure

2Therapeutics
01/2006 - 05/2001
1Hematopoietic Stem Cell Transplantation
01/2016
1Subcutaneous Injections
01/2006