Rama Krishna Kancha Selected Research

Therapeutics

4/2024	A simple and rapid pre-clinical in vivo model reveals comparative cardiotoxicity profiles of kinase inhibitors.
12/2022	Molecular docking analysis reveals differential binding affinities of multiple classes of selective inhibitors towards cancer-associated KRAS mutants.
10/2022	Estimated sensitivity profiles of lung cancer specific uncommon BRAF mutants towards experimental and clinically approved kinase inhibitors.
5/2017	Computational analysis of ABL kinase mutations allows predicting drug sensitivity against selective kinase inhibitors.

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Rama Krishna Kancha Research Topics

Disease

9	Neoplasms (Cancer) 01/2023 - 01/2011
3	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 10/2023 - 05/2017
3	Lung Neoplasms (Lung Cancer) 10/2022 - 01/2018
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2019 - 01/2009
2	Breast Neoplasms (Breast Cancer) 01/2017 - 01/2011
1	Cardiotoxicity 04/2024
1	Chromosome Aberrations (Chromosome Abnormalities) 01/2021
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2014
1	Leukemia 11/2008

Drug/Important Bio-Agent (IBA)

11	Phosphotransferases (Kinase)IBA 04/2024 - 01/2011
4	Imatinib Mesylate (Gleevec)FDA Link 10/2023 - 11/2008
3	ErbB Receptors (EGF Receptor)IBA 01/2019 - 01/2009
1	VemurafenibIBA 04/2024
1	Sorafenib (BAY 43-9006)FDA Link 04/2024
1	Metformin (Glucophage)FDA LinkGeneric 01/2023
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2023
1	Immune Checkpoint InhibitorsIBA 02/2022
1	Biomarkers (Surrogate Marker)IBA 12/2019
1	osimertinibIBA 01/2019
1	mobocertinibIBA 01/2019
1	HM781-36BIBA 01/2019
1	AfatinibIBA 01/2019
1	Tyrosine Kinase InhibitorsIBA 01/2019
1	IsoxazolesIBA 01/2017
1	Estrogen ReceptorsIBA 01/2017
1	ColforsinIBA 01/2017
1	Tyrosine (L-Tyrosine)FDA Link 01/2013
1	Lapatinib (GW572016)FDA Link 01/2011

Therapy/Procedure

4	Therapeutics 04/2024 - 05/2017