Thanasekaran Jayakumar Selected Research

Pulmonary Embolism

2/2024	Eugenol Suppresses Platelet Activation and Mitigates Pulmonary Thromboembolism in Humans and Murine Models.
8/2023	Garcinol acts as a novel integrin αIIbβ3 inhibitor in human platelets.
6/2023	Mechanisms of glabridin inhibition of integrin αIIbβ3 inside-out signals and NF-κB activation in human platelets.
9/2022	Glabridin, a Bioactive Flavonoid from Licorice, Effectively Inhibits Platelet Activation in Humans and Mice.
1/2022	Decreased Human Platelet Activation and Mouse Pulmonary Thrombosis by Rutaecarpine and Comparison of the Relative Effectiveness with BAY11-7082: Crucial Signals of p38-NF-κB.
6/2020	Carbon Dot Nanoparticles Exert Inhibitory Effects on Human Platelets and Reduce Mortality in Mice with Acute Pulmonary Thromboembolism.
11/2019	Suppression of Human Platelet Activation via Integrin αIIbβ3 Outside-In Independent Signal and Reduction of the Mortality in Pulmonary Thrombosis by Auraptene.
6/2019	Esculetin, a Coumarin Derivative, Prevents Thrombosis: Inhibitory Signaling on PLCγ2-PKC-AKT Activation in Human Platelets.
11/2018	Structure⁻Activity Relationship Study of Newly Synthesized Iridium-III Complexes as Potential Series for Treating Thrombotic Diseases.
6/2013	A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: ex vivo and in vivo studies.

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Thanasekaran Jayakumar Research Topics

Disease

13	Neoplasms (Cancer) 05/2020 - 01/2013
11	Pulmonary Embolism 02/2024 - 12/2011
11	Inflammation (Inflammations) 08/2022 - 01/2014
10	Thrombosis (Thrombus) 01/2022 - 06/2016
7	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 04/2020 - 01/2011
6	Cardiovascular Diseases (Cardiovascular Disease) 06/2023 - 08/2012
6	Stroke (Strokes) 04/2019 - 01/2013
5	Brain Ischemia (Cerebral Ischemia) 07/2017 - 01/2011
4	Ischemic Stroke 04/2020 - 04/2016
3	Obesity 09/2022 - 06/2019
3	Embolic Stroke 04/2020 - 09/2014
3	Infarction (Infarctions) 01/2017 - 01/2013
3	Melanoma (Melanoma, Malignant) 09/2015 - 01/2014
3	Hypoxia (Hypoxemia) 09/2014 - 01/2011
3	Reperfusion Injury 01/2014 - 01/2013
2	Brain Injuries (Brain Injury) 07/2017 - 04/2016
2	Brain Infarction 01/2017 - 04/2016
2	Ischemia 01/2017 - 01/2014
2	Ulcer 01/2017 - 01/2014
2	Wounds and Injuries (Trauma) 01/2017 - 01/2014
2	Thromboembolism 02/2016 - 12/2010
2	Chondrosarcoma 04/2013 - 05/2011
1	Joint Diseases (Joint Disease) 07/2020
1	Necrosis 07/2019
1	Renal Insufficiency (Renal Failure) 06/2019
1	Schizophrenia (Dementia Praecox) 01/2019
1	Atherosclerosis 11/2018
1	Vascular Diseases (Vascular Disease) 04/2018
1	Lung Neoplasms (Lung Cancer) 03/2018
1	Adenocarcinoma 03/2018
1	Adenocarcinoma of Lung 03/2018
1	Cerebral Infarction 01/2017
1	Brain Edema (Cerebral Edema) 01/2017

Drug/Important Bio-Agent (IBA)

6	Adenosine Diphosphate (ADP)IBA 01/2022 - 12/2011
6	Matrix Metalloproteinases (MMPs)IBA 07/2020 - 05/2011
6	beta-thujaplicinIBA 04/2018 - 01/2013
6	andrographolideIBA 07/2017 - 12/2011
5	Neuroprotective AgentsIBA 07/2017 - 01/2013
4	AntioxidantsIBA 08/2022 - 05/2014
4	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 07/2019 - 01/2011
4	Caspase 3 (Caspase-3)IBA 01/2015 - 01/2011
3	rutecarpineIBA 05/2022 - 10/2021
3	platonin (NK 19)IBA 04/2020 - 01/2014
3	EnzymesIBA 03/2018 - 05/2014
3	TropoloneIBA 05/2015 - 01/2013
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2014 - 01/2011
3	Glucose (Dextrose)FDA LinkGeneric 05/2014 - 01/2014
2	Fluorescein (Funduscein)FDA LinkGeneric 08/2023 - 06/2023
2	glabridinIBA 06/2023 - 09/2022
2	esculetinIBA 08/2022 - 06/2019
2	AlkaloidsIBA 05/2022 - 10/2021
2	IntegrinsIBA 05/2020 - 11/2019
2	RutheniumIBA 04/2020 - 07/2019
2	PlatinumIBA 05/2018 - 12/2017
2	Hydroxyl RadicalIBA 01/2017 - 01/2015
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2017 - 06/2016
2	Troleandomycin (TAO)FDA Link 01/2017 - 01/2011
2	Mitogen-Activated Protein KinasesIBA 04/2016 - 01/2014
2	p38 Mitogen-Activated Protein KinasesIBA 04/2016 - 01/2014
2	Proteins (Proteins, Gene)FDA Link 09/2015 - 11/2012
2	Tissue Plasminogen Activator (Alteplase)FDA Link 02/2015 - 09/2014
2	sesamolIBA 05/2011 - 12/2010
1	EugenolIBA 02/2024
1	FibrinIBA 08/2023
1	garcinolIBA 08/2023
1	CollagenIBA 06/2023
1	3- (4- methylphenylsulfonyl)- 2- propenenitrileIBA 01/2022
1	PhytochemicalsIBA 12/2021
1	SphingolipidsIBA 12/2021
1	Cyclic NucleotidesIBA 10/2021
1	Rosaniline Dyes (Fuchsin)IBA 04/2021
1	Reticulin (Reticular Fiber)IBA 04/2021
1	resorcinol (resorcin)IBA 04/2021
1	CarbonIBA 06/2020
1	columbianadinIBA 05/2020
1	Analgesics (Analgesic Drugs)IBA 05/2020
1	CymenesIBA 04/2020
1	quinolineIBA 04/2020
1	auraptenIBA 11/2019
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2019
1	CoumarinsIBA 06/2019
1	coumarinIBA 06/2019
1	TubulinIBA 04/2019
1	Poly I-CIBA 01/2019
1	Hemostatics (Antihemorrhagics)IBA 11/2018
1	FlavonoidsIBA 08/2018
1	morinIBA 08/2018
1	MetalsIBA 05/2018
1	Cisplatin (Platino)FDA LinkGeneric 05/2018
1	Monoterpenes (Monoterpenoids)IBA 03/2018
1	Organometallic CompoundsIBA 12/2017
1	IridiumIBA 12/2017
1	pyridineIBA 12/2017
1	DiterpenesIBA 07/2017
1	Therapeutic UsesIBA 07/2017
1	LactonesIBA 07/2017
1	triphenyltetrazoliumIBA 01/2017

Therapy/Procedure

2	Therapeutics 04/2019 - 02/2015
2	Renal Dialysis (Hemodialysis) 08/2013 - 11/2012
1	Chemoprevention 03/2018