Chimed Jansen Selected Research

African Trypanosomiasis (Nagana)

10/2018	Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.
4/2016	Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals.
3/2013	Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure.
10/2012	Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase B1.

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Chimed Jansen Research Topics

Disease

4	African Trypanosomiasis (Nagana) 10/2018 - 10/2012
2	Malaria 01/2019 - 01/2017
1	Tuberculosis (Tuberculoses) 10/2022
1	Cryptosporidiosis 01/2019
1	Trypanosomiasis 10/2018
1	Infections 01/2017

Drug/Important Bio-Agent (IBA)

3	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 04/2016 - 10/2012
2	Lysine-tRNA LigaseIBA 10/2022 - 01/2019
1	EnzymesIBA 10/2018
1	diethylstilbestrol monophosphate (PDES)IBA 10/2018
1	benzonidazole (benznidazole)IBA 01/2017
1	NifurtimoxIBA 01/2017
1	prolyl T RNA synthetaseIBA 01/2017
1	Cyclic NucleotidesIBA 03/2013

Therapy/Procedure

1	Oral Administration 01/2019