Nina Isoherranen Selected Research

Tretinoin (Retinoic Acid)

12/2018	Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis.
1/2017	Physiologically Based Pharmacokinetic Model of All-trans-Retinoic Acid with Application to Cancer Populations and Drug Interactions.
1/2016	ALDH Enzyme Expression Is Independent of the Spermatogenic Cycle, and Their Inhibition Causes Misregulation of Murine Spermatogenic Processes.
1/2015	Role of Retinoic Acid-Metabolizing Cytochrome P450s, CYP26, in Inflammation and Cancer.
5/2014	Inhibition of retinoic acid biosynthesis by the bisdichloroacetyldiamine WIN 18,446 markedly suppresses spermatogenesis and alters retinoid metabolism in mice.
4/2014	Levels of the retinoic acid synthesizing enzyme aldehyde dehydrogenase-1A2 are lower in testicular tissue from men with infertility.
1/2014	Nitric oxide and interleukin-1β stimulate the proteasome-independent degradation of the retinoic acid hydroxylase CYP2C22 in primary rat hepatocytes.
1/2011	Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis.

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Nina Isoherranen Research Topics

Disease

4	Epilepsy (Aura) 01/2004 - 02/2002
4	Seizures (Absence Seizure) 01/2004 - 02/2002
3	Inflammation (Inflammations) 01/2021 - 01/2015
3	Neoplasms (Cancer) 01/2017 - 01/2013
2	Acne Vulgaris 10/2023 - 01/2022
2	Gestational Diabetes (Gestational Diabetes Mellitus) 09/2023 - 05/2010
2	Chronic Renal Insufficiency 09/2023 - 11/2021
2	Drug-Related Side Effects and Adverse Reactions 01/2022 - 01/2019
2	Pain (Aches) 12/2021 - 11/2021
2	Dysbiosis 01/2021 - 12/2018
2	Male Infertility (Male Sterility) 01/2016 - 04/2014
2	Infertility (Sterility) 04/2014 - 01/2011
1	Chronic Disease (Chronic Diseases) 03/2024
1	Wounds and Injuries (Trauma) 03/2024
1	Heart Failure 11/2023
1	Intrahepatic Cholestasis of Pregnancy 09/2023
1	Kidney Diseases (Kidney Disease) 09/2023
1	Hematologic Neoplasms (Hematological Malignancy) 10/2022
1	Hypertrophy 01/2022
1	Neuroblastoma 01/2022
1	Heart Diseases (Heart Disease) 01/2022
1	Opiate Overdose 11/2021
1	Substance-Related Disorders (Drug Abuse) 11/2021
1	Labor Pain 11/2021
1	Vitamin A Deficiency 01/2021
1	Fibrosis (Cirrhosis) 01/2021
1	COVID-19 01/2021
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2021
1	Atrophy 12/2020
1	Weight Gain 12/2020
1	Dermatitis 12/2020
1	Splenomegaly 12/2020
1	Infections 01/2020
1	Salmonella Infections (Salmonellosis) 01/2020
1	Hypertension (High Blood Pressure) 10/2019
1	Disease Progression 01/2019
1	Shellfish Poisoning 01/2019
1	Tremor (Tremors) 01/2019
1	Non-alcoholic Fatty Liver Disease 01/2019
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2019
1	Chronic Kidney Failure (Chronic Renal Failure) 11/2017
1	Acute Promyelocytic Leukemia 01/2017
1	Weight Loss (Weight Reduction) 10/2016
1	Toxoplasmosis 01/2016
1	Cardiotoxicity 01/2016

Drug/Important Bio-Agent (IBA)

8	Vitamin A (Retinol)FDA LinkGeneric 03/2024 - 01/2015
8	Tretinoin (Retinoic Acid)FDA LinkGeneric 12/2018 - 01/2011
6	EnzymesIBA 03/2024 - 01/2014
5	Anticonvulsants (Antiepileptic Drugs)IBA 01/2004 - 02/2002
3	Proteins (Proteins, Gene)FDA Link 11/2023 - 01/2021
3	Opioid Analgesics (Opioids)IBA 12/2021 - 11/2021
3	RetinoidsIBA 01/2021 - 01/2015
2	Isotretinoin (Accutane)FDA LinkGeneric 10/2023 - 01/2022
2	Biomarkers (Surrogate Marker)IBA 09/2023 - 01/2019
2	Male Contraceptive Agents (Male Contraceptives)IBA 01/2016 - 05/2014
2	Cytochrome P450 Family 26IBA 01/2015 - 01/2013
2	Valproic Acid (Depakote)FDA LinkGeneric 01/2004 - 02/2002
2	Pentylenetetrazole (Metrazol)IBA 08/2003 - 02/2002
1	Retinyl EstersIBA 03/2024
1	nicotinamide-beta-ribosideIBA 11/2023
1	Short Chain Dehydrogenase-ReductasesIBA 11/2023
1	ChloridesIBA 11/2023
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 11/2023
1	Ribonuclease P (RNase P)IBA 11/2023
1	NAD (NADH)IBA 11/2023
1	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 10/2023
1	Cytochrome P-450 CYP3AIBA 10/2023
1	SphingolipidsIBA 09/2023
1	CreatinineIBA 09/2023
1	Tenofovir (Viread)FDA Link 09/2023
1	Carisoprodol (Soma)FDA LinkGeneric 01/2022
1	Carotenoids (Carotene)IBA 01/2022
1	Oxycodone (Oxycontin)FDA LinkGeneric 12/2021
1	Fentanyl (Sublimaze)FDA LinkGeneric 11/2021
1	Alfentanil (Alfenta)FDA LinkGeneric 11/2021
1	MucinsIBA 01/2021
1	NucleoproteinsIBA 01/2021
1	lecithin-retinol acyltransferaseIBA 01/2021
1	B-Lymphocyte Epitopes (B-Cell Epitope)IBA 01/2021
1	Retinol-Binding Proteins (Retinoid Binding Proteins)IBA 01/2021
1	AntigensIBA 01/2021
1	Retinoic Acid 4-Hydroxylase (CYP26B1)IBA 12/2020
1	Phenobarbital (Luminal)FDA Link 01/2020
1	Retinoic Acid Receptors (Retinoic Acid Receptor)IBA 01/2020
1	Interleukin-18 (Interleukin 18)IBA 01/2020
1	Sodium Chloride Symporter Inhibitors (Diuretics, Thiazide)IBA 10/2019
1	Hydrochlorothiazide (Esidrix)FDA LinkGeneric 10/2019
1	Antihypertensive Agents (Antihypertensives)IBA 10/2019
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2019
1	domoic acidIBA 01/2019
1	Prescription DrugsIBA 01/2019
1	NeurotoxinsIBA 01/2019
1	Interleukin-22 (IL-22)IBA 12/2018
1	Atomoxetine Hydrochloride (Strattera)FDA LinkGeneric 11/2017
1	Antidepressive Agents (Antidepressants)IBA 10/2016
1	Bupropion (Wellbutrin)FDA LinkGeneric 10/2016
1	calcium-dependent protein kinaseIBA 01/2016
1	Ether (Diethyl Ether)IBA 01/2016
1	CytochromesIBA 01/2015

Therapy/Procedure

8	Therapeutics 11/2023 - 01/2004