Graham P Holloway Selected Research

Adenosine Diphosphate (ADP)

1/2023	Acidosis attenuates CPT-I-supported bioenergetics as a potential mechanism limiting lipid oxidation.
1/2022	Nitrate consumption preserves HFD-induced skeletal muscle mitochondrial ADP sensitivity and lysine acetylation: A potential role for SIRT1.
11/2021	Revisiting the contribution of mitochondrial biology to the pathophysiology of skeletal muscle insulin resistance.
1/2021	Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment.
1/2021	Independent of mitochondrial respiratory function, dietary nitrate attenuates HFD-induced lipid accumulation and mitochondrial ROS emission within the liver.
1/2020	Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2 O2 emission.
1/2020	Ablating the Rab-GTPase activating protein TBC1D1 predisposes rats to high-fat diet-induced cardiomyopathy.
11/2018	High-Fat Diet Causes Mitochondrial Dysfunction as a Result of Impaired ADP Sensitivity.
8/2015	Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling.
12/2013	Submaximal ADP-stimulated respiration is impaired in ZDF rats and recovered by resveratrol.

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Graham P Holloway Research Topics

Disease

33	Insulin Resistance 07/2023 - 06/2007
14	Obesity 07/2023 - 06/2007
11	Type 2 Diabetes Mellitus (MODY) 01/2023 - 10/2009
10	Glucose Intolerance 01/2023 - 08/2014
4	Inflammation (Inflammations) 01/2023 - 01/2020
4	Fibrosis (Cirrhosis) 01/2023 - 06/2014
3	Mitochondrial Diseases (Mitochondrial Disease) 11/2018 - 01/2011
2	Fatty Liver 07/2023 - 01/2021
2	Atrophy 06/2023 - 10/2015
2	Muscular Atrophy (Muscle Atrophy) 06/2023 - 10/2016
2	Hypertrophy 01/2023 - 01/2020
2	Fatigue 01/2022 - 11/2019
2	Hyperlipidemias (Hyperlipidemia) 01/2021 - 08/2015
2	Weight Gain 01/2021 - 01/2016
2	Body Weight (Weight, Body) 01/2020 - 04/2015
2	Heart Failure 01/2020 - 01/2011
1	Non-alcoholic Fatty Liver Disease 07/2023
1	Weight Loss (Weight Reduction) 07/2023
1	Dysbiosis 01/2023
1	Acidosis 01/2023
1	Dyslipidemias (Dyslipidemia) 01/2023
1	Hyperglycemia 11/2021
1	Cardiomyopathies (Cardiomyopathy) 01/2020
1	Hyperphagia (Overeating) 01/2020
1	Multiple Myeloma 01/2018
1	Leukemia 01/2018
1	Neoplasms (Cancer) 01/2018
1	Hemorrhage 01/2018
1	Thrombocytopenia (Thrombopenia) 01/2018
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2018
1	Hematologic Neoplasms (Hematological Malignancy) 01/2018
1	Lymphoma (Lymphomas) 01/2018
1	Liver Diseases (Liver Disease) 01/2017
1	Bone Resorption 01/2016
1	Dyspnea (Shortness of Breath) 10/2015
1	Reperfusion Injury 02/2015

Drug/Important Bio-Agent (IBA)

18	LipidsIBA 01/2023 - 06/2007
18	Fatty Acids (Saturated Fatty Acids)IBA 01/2023 - 06/2007
11	Reactive Oxygen Species (Oxygen Radicals)IBA 06/2023 - 12/2013
10	Adenosine Diphosphate (ADP)IBA 01/2023 - 12/2013
9	Proteins (Proteins, Gene)FDA Link 06/2023 - 02/2008
8	Insulin (Novolin)FDA Link 01/2023 - 10/2015
8	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 02/2013
7	NitratesIBA 06/2023 - 01/2018
4	Palmitoyl Coenzyme A (Palmitoyl CoA)IBA 01/2023 - 06/2014
4	PalmitatesIBA 06/2011 - 06/2007
3	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 04/2016 - 10/2010
3	ResveratrolIBA 01/2016 - 12/2013
3	Coenzyme A (CoA)IBA 08/2015 - 11/2012
3	Triglycerides (Triacylglycerol)IBA 08/2014 - 04/2009
2	Malonyl Coenzyme A (Malonyl CoA)IBA 01/2023 - 08/2014
2	Pyruvic Acid (Pyruvate)IBA 01/2023 - 01/2020
2	Oxygen (Dioxygen)IBA 01/2023 - 01/2019
2	Succinic Acid (Succinate)IBA 01/2023 - 01/2020
2	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2023 - 11/2012
2	Acetyl-CoA CarboxylaseIBA 01/2021 - 08/2014
2	AntioxidantsIBA 01/2021 - 05/2015
2	Blood Glucose (Blood Sugar)IBA 01/2020 - 06/2014
2	Linoleic Acid (Linoleate)IBA 04/2016 - 07/2014
2	alpha-Linolenic Acid (Linolenic Acid)IBA 04/2016 - 07/2014
2	EnzymesIBA 10/2015 - 05/2015
2	CatalaseIBA 05/2015 - 02/2015
2	CeramidesIBA 08/2014 - 04/2014
2	PPAR deltaIBA 01/2009 - 06/2008
2	Transcription Factors (Transcription Factor)IBA 01/2009 - 06/2008
2	PPAR alphaIBA 01/2009 - 06/2008
1	CreatineIBA 07/2023
1	SalicylatesIBA 07/2023
1	AcidsIBA 07/2023
1	succinyl-trialanine-4-nitroanilide (SANA)IBA 07/2023
1	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 07/2023
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 06/2023
1	Muscle Proteins (Muscle Protein)IBA 06/2023
1	Carnitine (L-Carnitine)FDA LinkGeneric 01/2023
1	Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)IBA 01/2023
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2022
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2022
1	AMP-Activated Protein KinasesIBA 01/2021
1	JNK Mitogen-Activated Protein KinasesIBA 01/2020
1	sodium nitrateIBA 01/2020
1	Drinking WaterIBA 01/2020
1	rab GTP-Binding ProteinsIBA 01/2020
1	Adenosine Triphosphatases (ATPase)IBA 11/2019
1	Hemostatics (Antihemorrhagics)IBA 01/2018
1	microsomal triglyceride transfer proteinIBA 01/2017
1	ApolipoproteinsIBA 01/2017
1	Lipoproteins (Lipoprotein)IBA 01/2017
1	O(4)-methylthymidine triphosphateIBA 01/2017
1	MineralsIBA 01/2016
1	Cathepsin KIBA 01/2016
1	sarcolipinIBA 12/2015
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 10/2015
1	MyostatinIBA 10/2015

Therapy/Procedure

3	Bed Rest (Bedrest) 01/2020 - 10/2016
2	Caloric Restriction 07/2023 - 01/2020
1	Transplantation 01/2023
1	Drug Therapy (Chemotherapy) 01/2018
1	Endurance Training 01/2017
1	Therapeutics 01/2017
1	Physical Therapy Modalities (Physical Therapy Technique) 10/2015