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Eva J Helmerhorst Selected Research

Glutens (Glutelin)

12/2020Commensal Bacterium Rothia aeria Degrades and Detoxifies Gluten via a Highly Effective Subtilisin Enzyme.
7/2020Gluten Degrading Enzymes for Treatment of Celiac Disease.
1/2019Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo.
1/2017Salivary Gluten Degradation and Oral Microbial Profiles in Healthy Individuals and Celiac Disease Patients.
1/2016Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac disease.
12/2015Despite sequence homologies to gluten, salivary proline-rich proteins do not elicit immune responses central to the pathogenesis of celiac disease.
10/2015Salivary proline-rich proteins and gluten: Do structural similarities suggest a role in celiac disease?
6/2015Identification of Pseudolysin (lasB) as an Aciduric Gluten-Degrading Enzyme with High Therapeutic Potential for Celiac Disease.
10/2014Effect of Rothia mucilaginosa enzymes on gliadin (gluten) structure, deamidation, and immunogenic epitopes relevant to celiac disease.
5/2014Experimental Strategy to Discover Microbes with Gluten-degrading Enzyme Activities.
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Eva J Helmerhorst Research Topics

Disease

12Celiac Disease (Celiac Sprue)
12/2020 - 10/2010
2Inflammation (Inflammations)
12/2020 - 01/2017
2Periodontitis
01/2018 - 10/2014
2Infections
10/2014 - 05/2002
2Dental Plaque
10/2010 - 07/2008
2Chronic Kidney Failure (Chronic Renal Failure)
09/2008 - 03/2007
1Genetic Predisposition to Disease (Genetic Predisposition)
07/2020
1Autolysis
01/2019
1Periodontal Pocket (Periodontal Pockets)
10/2014
1Bone Resorption
10/2014
1Tooth Loss
10/2014
1Mycoses (Diseases, Fungus)
07/2005
1Candidiasis (Moniliasis)
05/2002
1Cystic Fibrosis (Mucoviscidosis)
05/2002
1Mucositis
05/2002
1Oral Candidiasis (Thrush)
05/2002
1Communicable Diseases (Infectious Diseases)
05/2002

Drug/Important Bio-Agent (IBA)

12Glutens (Glutelin)IBA
12/2020 - 10/2010
8EnzymesIBA
07/2020 - 07/2008
4Peptides (Polypeptides)IBA
07/2020 - 05/2002
3EpitopesIBA
01/2019 - 10/2014
2HLA-DQ8 antigenIBA
07/2020 - 10/2010
2Subtilisins (Subtilopeptidase A)IBA
01/2019 - 01/2016
2Proteins (Proteins, Gene)FDA Link
01/2016 - 07/2005
2Glutamine (L-Glutamine)FDA Link
01/2016 - 07/2008
2Salivary Proline-Rich ProteinsIBA
12/2015 - 10/2015
2GliadinIBA
10/2014 - 10/2010
2Biomarkers (Surrogate Marker)IBA
10/2014 - 09/2008
1monomethoxypolyethylene glycol (MPEG)IBA
01/2019
1antiarrhythmic peptide (AAP)IBA
01/2018
1Proline (L-Proline)FDA Link
01/2016
1ProstaglandinsIBA
10/2014
1Peptide Hydrolases (Proteases)FDA Link
10/2014
1Antigen-Antibody Complex (Immune Complex)IBA
10/2014
1CytokinesIBA
10/2014
1Uric Acid (Urate)IBA
09/2008
1NitritesIBA
09/2008
1HistatinsIBA
05/2002

Therapy/Procedure

1Renal Dialysis (Hemodialysis)
09/2008
1Optical Fibers
03/2007