David E Heinrichs Selected Research

Iron

1/2022	In vivo growth of Staphylococcus lugdunensis is facilitated by the concerted function of heme and non-heme iron acquisition mechanisms.
11/2021	Heme-Dependent Siderophore Utilization Promotes Iron-Restricted Growth of the Staphylococcus aureus hemB Small-Colony Variant.
1/2020	An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis.
1/2019	The heme-sensitive regulator SbnI has a bifunctional role in staphyloferrin B production by Staphylococcus aureus.
1/2018	SbnI is a free serine kinase that generates O -phospho-l-serine for staphyloferrin B biosynthesis in Staphylococcus aureus.
1/2016	A Heme-responsive Regulator Controls Synthesis of Staphyloferrin B in Staphylococcus aureus.
1/2016	Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation.
11/2014	Deferoxamine mesylate enhances virulence of community-associated methicillin resistant Staphylococcus aureus.
8/2014	Identification of a positively charged platform in Staphylococcus aureus HtsA that is essential for ferric staphyloferrin A transport.
5/2014	TCA cycle activity in Staphylococcus aureus is essential for iron-regulated synthesis of staphyloferrin A, but not staphyloferrin B: the benefit of a second citrate synthase.

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David E Heinrichs Research Topics

Disease

17	Infections 03/2024 - 03/2002
7	Starvation 11/2021 - 12/2004
3	Bacteremia 01/2023 - 10/2020
3	Abscess 11/2021 - 12/2014
2	Endocarditis 01/2024 - 01/2016
2	Sepsis (Septicemia) 01/2022 - 10/2020
2	Staphylococcal Infections 01/2019 - 04/2008
1	Persistent Infection 11/2021
1	Iron Overload 11/2014
1	Soft Tissue Infections 01/2012
1	Autolysis 11/2010
1	Pneumonia (Pneumonitis) 04/2010
1	Septic Shock (Toxic Shock Syndrome) 06/2009
1	Bacterial Infections (Bacterial Infection) 04/2008
1	Peritonitis 01/2008

Drug/Important Bio-Agent (IBA)

13	IronIBA 01/2022 - 03/2002
4	SiderophoresIBA 11/2021 - 01/2004
3	Virulence Factors (Pathogenicity Factors)IBA 03/2024 - 04/2010
3	SuperantigensIBA 01/2022 - 06/2009
3	Heme (Haem)IBA 01/2022 - 01/2016
3	Anti-Bacterial Agents (Antibiotics)IBA 10/2021 - 04/2008
3	staphyloferrin BIBA 01/2018 - 05/2014
2	purineIBA 01/2024 - 01/2020
2	Vancomycin FDA LinkGeneric 01/2024 - 01/2023
2	Proteins (Proteins, Gene)FDA Link 01/2018 - 11/2010
2	staphyloferrin AIBA 08/2014 - 05/2014
1	Cytotoxins (Cytolysins)IBA 03/2024
1	Zonula Occludens-1 ProteinIBA 03/2024
1	streptolysin OIBA 03/2024
1	streptolysin SIBA 03/2024
1	Interferon-gamma (Interferon, gamma)IBA 01/2022
1	Hemin (Panhematin)FDA Link 11/2021
1	MetalsIBA 11/2021
1	HLA-DR4 Antigen (HLA DR4 Antigen)IBA 10/2020
1	Fibrinogen (Factor I)FDA Link 12/2019
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	Fibronectins (Fibronectin)IBA 01/2019
1	Branched-Chain Amino AcidsIBA 01/2018
1	Phosphotransferases (Kinase)IBA 01/2018
1	Amino Acids FDA Link 01/2018
1	CoagulaseIBA 01/2016
1	Fatty Acids (Saturated Fatty Acids)IBA 06/2015
1	Triglycerides (Triacylglycerol)IBA 12/2014
1	LipidsIBA 12/2014
1	Deferoxamine (Desferal)FDA LinkGeneric 11/2014
1	Citrate (si)-Synthase (Synthase, Citrate)IBA 05/2014
1	Citric Acid (Citrate)FDA LinkGeneric 05/2014
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2012
1	AcidsIBA 11/2010
1	staphylococcal enterotoxin BIBA 06/2009
1	Toll-Like Receptor 2IBA 06/2009
1	LigandsIBA 06/2009
1	ExotoxinsIBA 06/2009
1	Peptidoglycan (Murein)IBA 06/2009
1	Interleukin-15 (Interleukin 15)IBA 04/2008

Therapy/Procedure

1	Therapeutics 01/2023
1	Reoperation 10/2021
1	Replacement Arthroplasty 10/2021
1	Arthroplasty 10/2021
1	Chelation Therapy (Therapy, Chelation) 11/2014
1	Peritoneal Dialysis 01/2008