Anthony R Fehr Selected Research

Therapeutics

4/2024	Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target.
12/2023	Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target.
4/2023	SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice.
1/2023	SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice.
1/2022	The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses.
1/2020	Murine Coronavirus Infection Activates the Aryl Hydrocarbon Receptor in an Indoleamine 2,3-Dioxygenase-Independent Manner, Contributing to Cytokine Modulation and Proviral TCDD-Inducible-PARP Expression.
1/2019	IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes.
4/2018	Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Anthony R Fehr Research Topics

Disease

24	Infections 04/2024 - 01/2010
14	Virus Diseases (Viral Diseases) 06/2023 - 05/2011
9	Coronavirus Infections 04/2024 - 01/2017
9	COVID-19 04/2024 - 10/2020
4	Severe Acute Respiratory Syndrome 01/2023 - 02/2016
2	Vesicular Stomatitis 04/2024 - 01/2023
2	Pneumonia (Pneumonitis) 01/2019 - 02/2016
2	Weight Loss (Weight Reduction) 01/2018 - 02/2015
1	Inflammation (Inflammations) 04/2024
1	Neoplasms (Cancer) 04/2024

Drug/Important Bio-Agent (IBA)

19	Proteins (Proteins, Gene)FDA Link 04/2024 - 01/2010
10	Antiviral Agents (Antivirals)IBA 04/2024 - 01/2018
7	Adenosine Diphosphate Ribose (ADP-Ribose)IBA 01/2024 - 02/2015
5	EndoribonucleasesIBA 04/2024 - 01/2017
5	InterferonsIBA 04/2024 - 02/2015
5	RNA (Ribonucleic Acid)IBA 04/2024 - 01/2017
4	Uridylate-Specific EndoribonucleasesIBA 04/2024 - 12/2021
4	Virulence Factors (Pathogenicity Factors)IBA 12/2021 - 10/2020
3	ADP-ribosylarginine hydrolaseIBA 04/2024 - 03/2021
3	2-5A-dependent ribonuclease (RNase L)IBA 04/2024 - 01/2022
3	VaccinesIBA 01/2022 - 04/2018
3	EnzymesIBA 12/2020 - 01/2020
3	CytokinesIBA 01/2020 - 02/2015
3	Viral DNAIBA 08/2013 - 01/2010
2	Ligases (Synthetase)IBA 04/2024 - 11/2023
2	Ribonucleases (Ribonuclease)IBA 04/2024 - 11/2023
2	2',5'-oligoadenylate (PAPAPA)IBA 04/2024 - 11/2023
2	Protein Kinases (Protein Kinase)IBA 04/2024 - 11/2023
2	Immunologic Factors (Immunomodulators)IBA 06/2023 - 01/2023
2	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2022 - 12/2021
2	AsparagineIBA 12/2021 - 03/2021
2	Niacinamide (Nicotinamide)FDA LinkGeneric 12/2020 - 10/2020
2	NAD (NADH)IBA 12/2020 - 10/2020
2	nicotinamide-beta-ribosideIBA 12/2020 - 10/2020
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020 - 02/2015
2	Viral ProteinsIBA 01/2017 - 01/2010
1	Poly I-CIBA 04/2024
1	ADP Ribose Transferases (ADP Ribosyltransferase)IBA 04/2024
1	Aurora KinasesIBA 01/2023
1	Carrier Proteins (Binding Protein)IBA 01/2023
1	DNA (Deoxyribonucleic Acid)IBA 01/2023
1	Histones (Histone)IBA 01/2023
1	Serine (L-Serine)FDA Link 01/2023
1	ChromatinIBA 12/2022
1	Nucleic AcidsIBA 12/2022
1	Complement System Proteins (Complement)IBA 01/2022
1	Peptide Hydrolases (Proteases)FDA Link 01/2022
1	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 01/2022
1	Ribose (D-Ribose)IBA 12/2021
1	Alanine (L-Alanine)FDA Link 03/2021
1	HydrolasesIBA 01/2021
1	Polychlorinated Dibenzodioxins (TCDD)IBA 01/2020
1	Transcription Factors (Transcription Factor)IBA 01/2020
1	InterleukinsIBA 01/2020
1	Attenuated VaccinesIBA 01/2020
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2020
1	Interleukin-10 (Interleukin 10)IBA 01/2020
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2020
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 01/2020
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 01/2020
1	Interferon alpha-beta Receptor (Receptor, Interferon alpha beta)IBA 01/2018
1	Adenosine Diphosphate (ADP)IBA 01/2018
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2018
1	Karyopherins (Importin)IBA 01/2018
1	Blocking AntibodiesIBA 01/2018
1	ProstaglandinsIBA 01/2017
1	Prostaglandin D2IBA 01/2017
1	DNA Primase (Primase)IBA 01/2017
1	Interferon Type IIBA 02/2016
1	ChemokinesIBA 02/2015
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 02/2015
1	Glycoproteins (Glycoprotein)IBA 01/2014
1	Phosphotransferases (Kinase)IBA 01/2012

Therapy/Procedure

8	Therapeutics 04/2024 - 04/2018
1	Ligation 01/2020