Assam El-Osta Selected Research

Glucose (Dextrose)

12/2023	Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products-induced inflammation.
11/2021	Deletion of GPR21 improves glucose homeostasis and inhibits the CCL2-CCR2 axis by divergent mechanisms.
11/2020	Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis.
1/2020	Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility.
1/2018	Metabolic Karma-The Atherogenic Legacy of Diabetes: The 2017 Edwin Bierman Award Lecture.
2/2015	Epigenetics and metabolism.
4/2012	Distinguishing hyperglycemic changes by Set7 in vascular endothelial cells.
11/2011	Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes.
10/2011	Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells.
12/2010	Glycemic memory associated epigenetic changes.

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Assam El-Osta Research Topics

Disease

22	Neoplasms (Cancer) 01/2023 - 11/2003
17	Hyperglycemia 03/2024 - 09/2008
15	Inflammation (Inflammations) 12/2023 - 12/2011
11	Diabetic Nephropathies (Diabetic Nephropathy) 12/2023 - 08/2005
11	Cardiovascular Diseases (Cardiovascular Disease) 01/2023 - 07/2006
9	Diabetes Complications 01/2018 - 09/2008
7	Fibrosis (Cirrhosis) 01/2023 - 08/2012
6	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2024 - 08/2005
6	Cardiomegaly (Heart Hypertrophy) 01/2018 - 01/2014
5	Type 2 Diabetes Mellitus (MODY) 10/2023 - 12/2010
5	Atherosclerosis 01/2023 - 01/2010
4	Hypertension (High Blood Pressure) 12/2023 - 03/2017
4	Albuminuria 10/2023 - 06/2014
4	Obesity 11/2021 - 03/2015
4	Heart Failure 10/2020 - 07/2014
4	Vascular System Injuries 01/2018 - 12/2010
3	Infections 01/2023 - 01/2019
3	Asthma (Bronchial Asthma) 11/2022 - 12/2011
3	Insulin Resistance 11/2021 - 03/2011
3	Diabetes Mellitus 11/2020 - 05/2013
3	Postural Orthostatic Tachycardia Syndrome 03/2017 - 08/2012
3	Hypertrophy 01/2015 - 10/2010
3	Panic Disorder (Panic Attack) 01/2013 - 07/2006
3	Ataxia Telangiectasia (Louis Bar Syndrome) 08/2010 - 04/2010
2	Dysbiosis 09/2022 - 03/2017
2	Hepatocellular Carcinoma (Hepatoma) 01/2019 - 01/2019
2	Vascular Diseases (Vascular Disease) 01/2018 - 07/2011
2	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2018 - 01/2016
2	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 03/2017 - 06/2011
2	Metabolic Diseases (Metabolic Disease) 01/2017 - 01/2014
2	Rett Syndrome (Rett's Disorder) 11/2013 - 04/2010
2	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 10/2013 - 01/2009
2	Pathologic Processes 08/2012 - 06/2010
2	Airway Remodeling 08/2012 - 12/2011
2	Respiratory Hypersensitivity 08/2012 - 12/2011
2	Epilepsy (Aura) 06/2009 - 07/2006
2	Genomic Instability 10/2004 - 09/2004
2	Carcinogenesis 09/2004 - 02/2004
1	Chronic Renal Insufficiency 12/2023
1	Kidney Diseases (Kidney Disease) 10/2023
1	Metaplasia 11/2022
1	Autoimmune Diseases (Autoimmune Disease) 01/2022
1	Hyperplasia 01/2022

Drug/Important Bio-Agent (IBA)

24	ChromatinIBA 03/2024 - 11/2003
13	Histones (Histone)IBA 01/2019 - 09/2004
12	Proteins (Proteins, Gene)FDA Link 01/2018 - 09/2004
10	Glucose (Dextrose)FDA LinkGeneric 12/2023 - 12/2010
8	Histone Deacetylase InhibitorsIBA 12/2011 - 07/2005
7	EnzymesIBA 01/2023 - 05/2009
7	DNA (Deoxyribonucleic Acid)IBA 02/2012 - 02/2004
6	CollagenIBA 11/2022 - 12/2011
6	Histone Deacetylases (Histone Deacetylase)IBA 07/2014 - 07/2006
5	Insulin (Novolin)FDA Link 01/2024 - 03/2014
5	Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)IBA 03/2017 - 07/2006
5	Histone MethyltransferasesIBA 07/2014 - 10/2004
4	Messenger RNA (mRNA)IBA 10/2023 - 07/2007
4	Transcription Factors (Transcription Factor)IBA 01/2018 - 07/2006
4	trichostatin A (A 300)IBA 01/2015 - 10/2010
4	MethyltransferasesIBA 04/2012 - 11/2003
3	Receptor for Advanced Glycation End ProductsIBA 12/2023 - 08/2005
3	Biomarkers (Surrogate Marker)IBA 10/2023 - 03/2012
3	Apolipoproteins E (ApoE)IBA 01/2018 - 06/2014
3	Streptozocin (Streptozotocin)FDA Link 01/2018 - 06/2014
3	Protein Isoforms (Isoforms)IBA 02/2016 - 10/2010
3	Valproic Acid (Depakote)FDA LinkGeneric 12/2011 - 07/2006
3	Protein Kinases (Protein Kinase)IBA 08/2010 - 04/2010
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 11/2021 - 01/2020
2	Complement C5a (Complement 5a)IBA 01/2021 - 01/2020
2	CholesterolIBA 11/2020 - 01/2014
2	Small Interfering RNA (siRNA)IBA 01/2019 - 10/2005
2	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2018 - 02/2016
2	CytokinesIBA 01/2018 - 03/2014
2	MineralocorticoidsIBA 01/2018 - 03/2017
2	LipidsIBA 01/2018 - 02/2015
2	Volatile Fatty AcidsIBA 03/2017 - 06/2009
2	NADPH Oxidases (NAD(P)H oxidase)IBA 02/2016 - 06/2014
2	Superoxides (Superoxide)IBA 02/2016 - 09/2008
2	NF-kappa B (NF-kB)IBA 01/2015 - 09/2008
2	theasinensin AIBA 01/2015 - 08/2012
2	Carrier Proteins (Binding Protein)IBA 11/2013 - 10/2004
2	Methacholine Chloride (Methacholine)FDA Link 08/2012 - 12/2011
2	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2011 - 10/2010
2	AnthracyclinesIBA 12/2011 - 10/2010
2	Radioisotopes (Radionuclides)IBA 01/2011 - 02/2006
2	Lysine (L-Lysine)FDA Link 12/2010 - 05/2009
2	Epinephrine (Adrenaline)FDA LinkGeneric 12/2008 - 07/2006
1	GTP-Binding Proteins (G-Protein)IBA 12/2023
1	Glucagon-Like Peptide 1 (GLP 1)IBA 12/2023
1	Liraglutide FDA Link 12/2023
1	Glucagon-Like Peptide-1 ReceptorIBA 12/2023
1	Nucleic AcidsIBA 01/2023
1	histone H3 trimethyl Lys4IBA 01/2023
1	sulforaphaneIBA 11/2022
1	OvalbuminIBA 11/2022
1	Butyrates (Butyrate)IBA 09/2022
1	Sirolimus (Rapamycin)FDA Link 01/2022

Therapy/Procedure

20	Therapeutics 12/2023 - 07/2005
6	Radiotherapy 01/2011 - 02/2006
5	Glycemic Control 11/2012 - 05/2009
4	Drug Therapy (Chemotherapy) 01/2019 - 09/2004