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Jacob D Durrant Selected Research

African Trypanosomiasis (Nagana)

11/2014POVME 2.0: An Enhanced Tool for Determining Pocket Shape and Volume Characteristics.
8/2012The molecular dynamics of Trypanosoma brucei UDP-galactose 4'-epimerase: a drug target for African sleeping sickness.
10/2011CrystalDock: a novel approach to fragment-based drug design.
8/2011Towards the development of novel Trypanosoma brucei RNA editing ligase 1 inhibitors.
8/2010Novel naphthalene-based inhibitors of Trypanosoma brucei RNA editing ligase 1.
7/2010Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness.

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Jacob D Durrant Research Topics

Disease

8Human Influenza (Influenza)
09/2023 - 04/2010
6African Trypanosomiasis (Nagana)
11/2014 - 07/2010
2Starvation
01/2023 - 01/2022
2Chagas Disease (American Trypanosomiasis)
01/2017 - 09/2012
2Drug-Related Side Effects and Adverse Reactions
07/2010 - 01/2010
1Bartter Syndrome (Syndrome, Bartter)
11/2023
1Inborn Genetic Diseases (Disease, Hereditary)
11/2023
1Bacterial Infections (Bacterial Infection)
01/2015
1Disease Progression
09/2012
1Infections
08/2010
1Neglected Diseases
08/2010
1Vascular Diseases (Vascular Disease)
03/2010
1Multiple Sclerosis
03/2010
1Neoplasms (Cancer)
03/2010
1Alzheimer Disease (Alzheimer's Disease)
03/2010

Drug/Important Bio-Agent (IBA)

8Neuraminidase (Sialidase)IBA
09/2023 - 04/2010
3HexokinaseIBA
09/2023 - 01/2023
3Proteins (Proteins, Gene)FDA Link
09/2023 - 04/2010
3Ligases (Synthetase)IBA
11/2014 - 01/2010
2Heat-Shock Proteins (Heat-Shock Protein)IBA
09/2023 - 05/2023
2N-Acetylneuraminic Acid (Sialic Acid)IBA
02/2020 - 11/2018
1ElectrolytesIBA
11/2023
1Potassium Channels (Potassium Channel)IBA
11/2023
1Glucose (Dextrose)FDA LinkGeneric
01/2023
12-deoxyglucose-6-phosphateIBA
01/2022
1Membrane Glycoproteins (Membrane Glycoprotein)IBA
02/2020
1Hemagglutinins (Hemagglutinin)IBA
11/2018
1MMV001239IBA
01/2017
1benzamideIBA
01/2017
1Membrane Proteins (Integral Membrane Proteins)IBA
01/2016
1cruzipainIBA
09/2012
1divinyl sulfoneIBA
09/2012
1UDPglucose 4-Epimerase (UDP Galactose Epimerase)IBA
08/2012
1Uridine Diphosphate Galactose (UDP Galactose)IBA
07/2010
1Matrix Metalloproteinases (MMPs)IBA
03/2010
1AcidsIBA
01/2010

Therapy/Procedure

7Therapeutics
02/2020 - 04/2010
3Transcutaneous Electric Nerve Stimulation (TENS)
01/2015 - 07/2010