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Fernando Doñate Selected Research

Neoplasms (Cancer)

1/2019In vitro and in vivo efficacy of an anti-CD203c conjugated antibody (AGS-16C3F) in mouse models of advanced systemic mastocytosis.
1/2017Inhibition of Megakaryocyte Differentiation by Antibody-Drug Conjugates (ADCs) is Mediated by Macropinocytosis: Implications for ADC-induced Thrombocytopenia.
1/2017A Potential Mechanism for ADC-Induced Neutropenia: Role of Neutrophils in Their Own Demise.
11/2016The Discovery and Preclinical Development of ASG-5ME, an Antibody-Drug Conjugate Targeting SLC44A4-Positive Epithelial Tumors Including Pancreatic and Prostate Cancer.
4/2016AGS16F Is a Novel Antibody Drug Conjugate Directed against ENPP3 for the Treatment of Renal Cell Carcinoma.
1/2016Enfortumab Vedotin Antibody-Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models.
1/2016Development of ASG-15ME, a Novel Antibody-Drug Conjugate Targeting SLITRK6, a New Urothelial Cancer Biomarker.
7/2015AGS67E, an Anti-CD37 Monomethyl Auristatin E Antibody-Drug Conjugate as a Potential Therapeutic for B/T-Cell Malignancies and AML: A New Role for CD37 in AML.
2/2010The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3.
5/2008Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling.
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Fernando Doñate Research Topics

Disease

20Neoplasms (Cancer)
01/2019 - 09/2002
3Renal Cell Carcinoma (Grawitz Tumor)
01/2018 - 04/2016
2Neoplasm Metastasis (Metastasis)
12/2006 - 09/2006
2Carcinoma (Carcinomatosis)
10/2002 - 08/2002
1Systemic Mastocytosis
01/2019
1Leukemia
01/2019
1Toxic Optic Neuropathy
01/2018
1Thrombocytopenia (Thrombopenia)
01/2017
1Neutropenia
01/2017
1Pancreatic Neoplasms (Pancreatic Cancer)
11/2016
1Prostatic Neoplasms (Prostate Cancer)
11/2016
1Lung Neoplasms (Lung Cancer)
01/2016
1Urinary Bladder Neoplasms (Bladder Cancer)
01/2016
1Non-Hodgkin Lymphoma (Lymphosarcoma)
07/2015
1B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
07/2015
1T-Cell Lymphoma (Lymphoma, T Cell)
07/2015
1Melanoma (Melanoma, Malignant)
12/2009
1Lewis Lung Carcinoma
04/2008
1Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
06/2007
1Inflammation (Inflammations)
06/2007
1Disease Progression
06/2007
1Colitis
06/2007
1Breast Neoplasms (Breast Cancer)
09/2006
1Hematologic Neoplasms (Hematological Malignancy)
08/2006
1Necrosis
10/2002
1Infarction (Infarctions)
10/2002

Drug/Important Bio-Agent (IBA)

9Immunoconjugates (Immunoconjugate)IBA
01/2019 - 07/2015
5Phosphoric Diester Hydrolases (Phosphodiesterases)IBA
01/2019 - 04/2016
5Proteins (Proteins, Gene)FDA Link
01/2016 - 10/2002
4AGS-16C3FIBA
01/2019 - 01/2017
4PyrophosphatasesIBA
01/2018 - 04/2016
4AntigensIBA
04/2016 - 10/2002
4Peptides (Polypeptides)IBA
04/2008 - 08/2004
3acetyl- prolyl- histidyl- seryl- cysteinyl- asparaginamideIBA
04/2008 - 09/2006
3matrigelIBA
04/2008 - 09/2002
3IntegrinsIBA
04/2008 - 07/2004
2monomethylauristatin FIBA
01/2018 - 04/2016
2Choline (Choline Chloride)IBA
11/2016 - 08/2006
2tetrathiomolybdate (ammonium tetrathiomolybdate)IBA
12/2009 - 08/2006
2Fibronectins (Fibronectin)IBA
09/2006 - 07/2004
2ThrombogenIBA
07/2004 - 10/2002
1AntibodiesIBA
01/2019
1nucleotide pyrophosphataseIBA
01/2019
1Ado-Trastuzumab EmtansineIBA
01/2017
1Peptide Hydrolases (Proteases)FDA Link
01/2017
1Serine Proteases (Serine Protease)IBA
01/2017
1130-nm albumin-bound paclitaxelIBA
11/2016
1Phenobarbital (Luminal)FDA Link
11/2016
1ASG-5MEIBA
11/2016
1CaspasesIBA
04/2016
1Keratin-18 (Keratin 18)IBA
04/2016
1sirtratumab vedotinIBA
01/2016
1enfortumab vedotinIBA
01/2016
1Immunoglobulins (Immunoglobulin)IBA
01/2016
1AGS67EIBA
07/2015
1monomethyl auristatin EIBA
07/2015
1ProdrugsIBA
02/2010
1PR-104IBA
02/2010
1PR-104AIBA
02/2010
1Temozolomide (Temodar)FDA LinkGeneric
12/2009
1MetalsIBA
12/2009
1Reactive Oxygen Species (Oxygen Radicals)IBA
12/2009
1Melanins (Melanin)IBA
12/2009
1Superoxide DismutaseIBA
12/2009
1Alkylating AgentsIBA
12/2009
1Superoxides (Superoxide)IBA
05/2008
1AntioxidantsIBA
05/2008
16-pyruvoyltetrahydropterin synthase (PTPS)IBA
05/2008
1Cysteine (L-Cysteine)FDA Link
04/2008
1Sulfhydryl Compounds (Thiols)IBA
04/2008
1SodiumIBA
06/2007
1Interleukin-10 (Interleukin 10)IBA
06/2007
1Therapeutic UsesIBA
06/2007
1Dextrans (Dextran)FDA Link
06/2007
1Thymidine PhosphorylaseIBA
12/2006
1Mitogen-Activated Protein KinasesIBA
09/2006
1Green Fluorescent ProteinsIBA
09/2006
1CopperIBA
08/2006
1ChloridesIBA
08/2006
1Superoxide Dismutase-1IBA
08/2006
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
11/2004
1Bevacizumab (Avastin)FDA Link
11/2004
1TropomyosinIBA
08/2004
1Proline (L-Proline)FDA Link
08/2004
1Histidine (L-Histidine)FDA Link
08/2004
1CarboxypeptidasesIBA
10/2002
1Thromboplastin (Tissue Factor)IBA
10/2002
1Doxorubicin (Adriamycin)FDA LinkGeneric
10/2002
1Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
08/2002

Therapy/Procedure

4Therapeutics
01/2019 - 10/2002