Ralph A DeFronzo Selected Research

Diabetes Mellitus

8/2011	Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose.
7/2003	Influence of ethnicity and familial diabetes on glucose tolerance and insulin action: a physiological analysis.

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Ralph A DeFronzo Research Topics

Disease

133	Type 2 Diabetes Mellitus (MODY) 01/2024 - 02/2002
118	Insulin Resistance 01/2024 - 03/2002
34	Glucose Intolerance 12/2023 - 01/2003
26	Hyperglycemia 01/2023 - 11/2002
18	Obesity 01/2023 - 01/2004
15	Prediabetic State (Prediabetes) 01/2023 - 06/2009
15	Hypoglycemia (Reactive Hypoglycemia) 10/2022 - 05/2005
14	Cardiovascular Diseases (Cardiovascular Disease) 01/2023 - 11/2006
12	Weight Gain 01/2021 - 05/2005
11	Body Weight (Weight, Body) 01/2024 - 06/2003
10	Weight Loss (Weight Reduction) 10/2018 - 05/2005
9	Inflammation (Inflammations) 08/2022 - 04/2007
8	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 07/2006
7	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2023 - 04/2007
6	Dyslipidemias (Dyslipidemia) 01/2023 - 04/2007
6	Non-alcoholic Fatty Liver Disease 01/2023 - 01/2011
6	Hypertension (High Blood Pressure) 01/2023 - 01/2018
5	Hyperinsulinism (Hyperinsulinemia) 01/2022 - 02/2005
4	Myocardial Infarction 01/2020 - 08/2011
4	Atherosclerosis 12/2019 - 02/2005
4	Stroke (Strokes) 01/2017 - 05/2006
3	Glycosuria 07/2023 - 09/2008
3	Heart Failure 01/2023 - 05/2006
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 10/2022 - 06/2016
3	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2018 - 05/2011
2	Chronic Renal Insufficiency 01/2023 - 01/2022
2	Infections 12/2022 - 07/2018
2	Fibrosis (Cirrhosis) 01/2022 - 01/2011
2	Ketosis 01/2020 - 01/2019
2	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 01/2019 - 06/2016
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2018 - 05/2006
2	Chronic Kidney Failure (Chronic Renal Failure) 10/2017 - 05/2003
2	Overweight 08/2015 - 04/2009
2	Disease Progression 05/2014 - 03/2010
2	Diabetes Mellitus 08/2011 - 07/2003
2	Edema (Dropsy) 03/2011 - 05/2006

Drug/Important Bio-Agent (IBA)

122	Glucose (Dextrose)FDA LinkGeneric 01/2024 - 02/2002
93	Insulin (Novolin)FDA Link 07/2023 - 02/2002
33	Pioglitazone (Actos)FDA Link 01/2023 - 03/2002
23	Metformin (Glucophage)FDA LinkGeneric 01/2024 - 05/2005
17	Exenatide (Byetta)FDA Link 07/2023 - 05/2005
17	LipidsIBA 01/2022 - 05/2003
15	empagliflozinIBA 01/2024 - 03/2015
15	Nonesterified Fatty Acids (NEFA)IBA 01/2017 - 08/2002
12	C-PeptideIBA 01/2024 - 01/2005
12	AdiponectinIBA 01/2021 - 01/2004
11	Glucagon (Glukagon)FDA Link 07/2023 - 05/2006
11	Triglycerides (Triacylglycerol)IBA 01/2022 - 05/2006
10	Sodium-Glucose Transporter 2 InhibitorsIBA 12/2023 - 09/2008
10	Hypoglycemic Agents (Hypoglycemics)IBA 10/2022 - 08/2005
9	dapagliflozinIBA 07/2023 - 08/2013
8	Glucagon-Like Peptide 1 (GLP 1)IBA 07/2023 - 05/2006
8	HDL CholesterolIBA 01/2021 - 05/2006
8	IncretinsIBA 08/2016 - 05/2005
6	Fatty Acids (Saturated Fatty Acids)IBA 01/2021 - 01/2010
6	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2006
6	Glucagon-Like Peptide-1 Receptor AgonistsIBA 01/2021 - 07/2013
6	Sodium-Glucose Transport ProteinsIBA 08/2016 - 09/2008
5	Liraglutide FDA Link 01/2024 - 08/2015
5	SodiumIBA 01/2022 - 06/2016
5	Adenosine Triphosphate (ATP)IBA 01/2021 - 09/2008
5	EnzymesIBA 01/2021 - 07/2006
5	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2021 - 05/2015
5	LinagliptinIBA 07/2018 - 03/2015
4	Sitagliptin Phosphate (Januvia)FDA Link 01/2024 - 09/2013
4	KetonesIBA 01/2023 - 11/2016
4	Glucagon-Like Peptide-1 ReceptorIBA 08/2022 - 05/2006
4	Blood Glucose (Blood Sugar)IBA 01/2021 - 03/2010
4	GlycogenIBA 12/2018 - 02/2002
4	ThiazolidinedionesIBA 03/2007 - 08/2003
3	glimepiride (Amarel)FDA LinkGeneric 01/2024 - 04/2018
3	Arginine (L-Arginine)FDA Link 01/2021 - 01/2008
3	2,4-thiazolidinedione (thiazolidinedione)IBA 12/2020 - 01/2004
3	Hemoglobins (Hemoglobin)IBA 12/2018 - 04/2007
3	AdipokinesIBA 12/2016 - 09/2004
3	acipimoxIBA 03/2016 - 09/2004
2	Insulin Glargine (Lantus)FDA Link 01/2024 - 11/2006
2	Bromocriptine (Parlodel)FDA LinkGeneric 08/2022 - 10/2018
2	CarbohydratesIBA 01/2022 - 11/2006
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2011
2	Insulin ReceptorIBA 01/2021 - 05/2014
2	CeramidesIBA 01/2021 - 01/2004
2	Carotenoids (Carotene)IBA 01/2021 - 07/2017
2	Drug CombinationsIBA 01/2020 - 09/2015
2	omega-Chloroacetophenone (Mace)IBA 01/2020 - 01/2017
2	Small Interfering RNA (siRNA)IBA 01/2018 - 05/2015
2	CreatinineIBA 10/2017 - 05/2003
2	HDL LipoproteinsIBA 07/2017 - 04/2007
2	Streptozocin (Streptozotocin)FDA Link 08/2015 - 12/2012
2	PalmitatesIBA 05/2015 - 11/2014
2	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2015 - 08/2011
2	Neurotransmitter Agents (Neurotransmitter)IBA 05/2014 - 03/2010
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 08/2013 - 05/2006
2	alogliptinIBA 09/2010 - 12/2008
2	Rosiglitazone (Avandia)FDA Link 05/2010 - 11/2006
2	Hemoglobin AIBA 03/2010 - 11/2002
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2008 - 11/2006

Therapy/Procedure

44	Therapeutics 01/2024 - 02/2002
22	Glycemic Control 01/2024 - 03/2002
4	Drug Therapy (Chemotherapy) 10/2022 - 10/2014