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Ralph B D'Agostino Selected Research

lonafarnib (SCH 66336)

1/2018Survey of plasma proteins in children with progeria pre-therapy and on-therapy with lonafarnib.
1/2018Association of Lonafarnib Treatment vs No Treatment With Mortality Rate in Patients With Hutchinson-Gilford Progeria Syndrome.
7/2016Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome.

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Ralph B D'Agostino Research Topics

Disease

68Cardiovascular Diseases (Cardiovascular Disease)
01/2021 - 06/2002
38Hypertension (High Blood Pressure)
04/2024 - 02/2002
37Neoplasms (Cancer)
01/2024 - 01/2007
34Type 2 Diabetes Mellitus (MODY)
11/2021 - 08/2002
32Insulin Resistance
01/2015 - 08/2002
30Atherosclerosis
01/2018 - 04/2003
27Myocardial Infarction
01/2019 - 01/2000
26Heart Failure
05/2021 - 03/2003
26Stroke (Strokes)
01/2021 - 06/2002
23Obesity
01/2024 - 08/2003
23Coronary Disease (Coronary Heart Disease)
10/2017 - 03/2003
20Breast Neoplasms (Breast Cancer)
04/2024 - 07/2011
20Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2024 - 03/2009
18Metabolic Syndrome (Dysmetabolic Syndrome X)
09/2014 - 04/2003
17Inflammation (Inflammations)
01/2021 - 07/2004
17Diabetes Mellitus
01/2019 - 05/2006
14Coronary Artery Disease (Coronary Atherosclerosis)
01/2024 - 08/2002
13Glucose Intolerance
01/2010 - 08/2002
11Dyslipidemias (Dyslipidemia)
11/2021 - 04/2003
9Chronic Renal Insufficiency
01/2019 - 05/2007
9Atrial Fibrillation
01/2018 - 12/2003
7Hemorrhage
05/2017 - 10/2004
6Neoplasm Metastasis (Metastasis)
11/2021 - 12/2006
6Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
04/2009 - 10/2002
6Overweight
03/2009 - 09/2002
6Dementia (Dementias)
05/2008 - 02/2002
5Squamous Cell Carcinoma of Head and Neck
07/2023 - 01/2018
5Renal Artery Obstruction (Renal Artery Stenosis)
01/2019 - 01/2014
5Prostatic Neoplasms (Prostate Cancer)
11/2018 - 02/2007
5Ischemic Stroke
01/2018 - 08/2003
5Peripheral Arterial Disease
01/2018 - 07/2004
5Infections
03/2013 - 06/2004
4Cardiotoxicity
02/2024 - 09/2010
4Head and Neck Neoplasms (Head and Neck Cancer)
11/2023 - 04/2008
4Progeria (Hutchinson Gilford Syndrome)
01/2023 - 07/2016
4Brain Neoplasms (Brain Tumor)
01/2020 - 03/2006
4Acute Coronary Syndrome
01/2018 - 03/2012
4Thrombosis (Thrombus)
05/2017 - 04/2004
4Peripheral Vascular Diseases (Peripheral Vascular Disease)
01/2017 - 08/2006
4Isolated Systolic Hypertension
01/2016 - 08/2004
4Carotid Stenosis (Carotid Artery Stenosis)
09/2009 - 07/2005
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
11/2023 - 01/2023
3Premature Aging
01/2023 - 07/2016
3Sarcoma (Soft Tissue Sarcoma)
01/2020 - 08/2017
3Lymphoma (Lymphomas)
01/2020 - 08/2017
3Hyperlipidemias (Hyperlipidemia)
01/2018 - 02/2015
3Vascular Diseases (Vascular Disease)
01/2018 - 03/2003

Drug/Important Bio-Agent (IBA)

46HDL CholesterolIBA
01/2024 - 10/2002
33CholesterolIBA
01/2018 - 10/2002
33Glucose (Dextrose)FDA LinkGeneric
01/2017 - 06/2002
28LipidsIBA
11/2021 - 01/2000
27Triglycerides (Triacylglycerol)IBA
11/2021 - 03/2003
26C-Reactive ProteinIBA
11/2019 - 10/2002
24Biomarkers (Surrogate Marker)IBA
11/2021 - 03/2005
19Insulin (Novolin)FDA Link
09/2014 - 08/2002
15Antihypertensive Agents (Antihypertensives)IBA
04/2024 - 01/2000
14LDL CholesterolIBA
10/2019 - 02/2005
13oxidized low density lipoproteinIBA
11/2021 - 05/2003
12Fibrinogen (Factor I)FDA Link
11/2019 - 04/2003
11Proteins (Proteins, Gene)FDA Link
01/2023 - 02/2004
11CalciumIBA
01/2021 - 03/2006
11Lipoproteins (Lipoprotein)IBA
01/2017 - 03/2003
10HomocysteineIBA
03/2011 - 02/2002
9Interleukin-6 (Interleukin 6)IBA
11/2019 - 03/2003
9CreatinineIBA
01/2019 - 12/2003
8AnthracyclinesIBA
01/2020 - 11/2014
8Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
10/2019 - 04/2014
8ApolipoproteinsIBA
01/2019 - 03/2002
6Estrogens (Estrogen)FDA Link
02/2024 - 01/2000
6lipoprotein cholesterolIBA
03/2016 - 02/2005
6LDL Lipoproteins (beta Lipoproteins)IBA
01/2016 - 01/2006
6PotassiumIBA
05/2014 - 02/2003
5Hormones (Hormone)IBA
02/2024 - 06/2010
5Brain Natriuretic Peptide (Natrecor)FDA Link
01/2018 - 08/2007
5Alanine Transaminase (SGPT)IBA
12/2008 - 10/2004
5Hemostatics (Antihemorrhagics)IBA
02/2006 - 11/2002
4Doxorubicin (Adriamycin)FDA LinkGeneric
05/2024 - 09/2010
4C-PeptideIBA
01/2024 - 06/2007
4AutoantibodiesIBA
01/2024 - 07/2011
4Hemoglobins (Hemoglobin)IBA
08/2021 - 05/2007
4DNA (Deoxyribonucleic Acid)IBA
06/2021 - 12/2012
4Cystatin CIBA
01/2019 - 03/2014
4AdiponectinIBA
11/2018 - 08/2008
4Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
01/2018 - 04/2006
4Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
05/2017 - 10/2004
4F2-Isoprostanes (F2 Isoprostanes)IBA
01/2017 - 01/2012
4ORALIT (ORS)IBA
06/2013 - 04/2007
4AdipokinesIBA
04/2011 - 08/2008
4AlbuminsIBA
03/2009 - 03/2005
3CarbohydratesIBA
11/2020 - 12/2005
3Apolipoprotein A-I (Apolipoprotein A1)IBA
01/2019 - 08/2007
3lonafarnib (SCH 66336)IBA
01/2018 - 07/2016

Therapy/Procedure

34Therapeutics
02/2024 - 08/2002
16Drug Therapy (Chemotherapy)
04/2024 - 06/2008
14Radiotherapy
05/2024 - 12/2006
10Glycemic Control
11/2021 - 03/2009
6Catheters
01/2019 - 09/2010
4Immunotherapy
07/2023 - 01/2020
3Adjuvant Chemotherapy
04/2024 - 01/2017
3Secondary Prevention
01/2018 - 07/2017