Mark Clendenning Selected Research

Neoplasms (Cancer)

10/2023	A mosaic pathogenic variant in MSH6 causes MSH6-deficient colorectal and endometrial cancer in a patient classified as suspected Lynch syndrome: a case report.
3/2023	Genotoxic colibactin mutational signature in colorectal cancer is associated with clinicopathological features, specific genomic alterations and better survival.
3/2023	A tumor focused approach to resolving the etiology of DNA mismatch repair deficient tumors classified as suspected Lynch syndrome.
2/2023	Evaluating Multiple Next-Generation Sequencing-Derived Tumor Features to Accurately Predict DNA Mismatch Repair Status.
1/2023	A tumor focused approach to resolving the etiology of DNA mismatch repair deficient tumors classified as suspected Lynch syndrome.
1/2020	Mismatch repair gene pathogenic germline variants in a population-based cohort of breast cancer.
1/2018	RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers.
1/2018	Associations of alcohol intake, smoking, physical activity and obesity with survival following colorectal cancer diagnosis by stage, anatomic site and tumor molecular subtype.
11/2017	Targeted sequencing of established and candidate colorectal cancer genes in the Colon Cancer Family Registry Cohort.
9/2017	Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes.

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Mark Clendenning Research Topics

Disease

34	Neoplasms (Cancer) 10/2023 - 05/2006
29	Colorectal Neoplasms (Colorectal Cancer) 01/2024 - 02/2008
15	Hereditary Nonpolyposis Colorectal Neoplasms (Hereditary Nonpolyposis Colorectal Cancer) 01/2020 - 08/2008
12	Microsatellite Instability 03/2023 - 02/2007
6	Colonic Neoplasms (Colon Cancer) 01/2021 - 05/2012
5	Endometrial Neoplasms (Endometrial Cancer) 02/2023 - 07/2013
5	Turcot syndrome 01/2019 - 01/2009
3	Breast Neoplasms (Breast Cancer) 01/2020 - 04/2010
3	Adenoma (Adenomas) 01/2018 - 07/2010
3	Polyps 06/2012 - 07/2010
1	Diabetes Mellitus 11/2019
1	Type 2 Diabetes Mellitus (MODY) 11/2019
1	Prostatic Neoplasms (Prostate Cancer) 12/2014
1	Necrosis 04/2010
1	Intellectual Disability (Idiocy) 02/2008
1	Agammaglobulinemia (Hypogammaglobulinemia) 02/2008
1	Astrocytoma (Pilocytic Astrocytoma) 02/2008

Drug/Important Bio-Agent (IBA)

18	Proteins (Proteins, Gene)FDA Link 01/2019 - 02/2007
14	DNA (Deoxyribonucleic Acid)IBA 01/2024 - 07/2013
8	Calcibiotic Root Canal SealerIBA 12/2023 - 01/2009
4	A-Form DNA (A-DNA)IBA 01/2016 - 08/2011
3	Epithelial Cell Adhesion MoleculeIBA 01/2021 - 11/2015
3	Biomarkers (Surrogate Marker)IBA 01/2017 - 03/2015
3	Mismatch Repair Endonuclease PMS2IBA 09/2013 - 05/2006
2	Codon (Codons)IBA 01/2018 - 06/2013
2	Ethanol (Ethyl Alcohol)IBA 01/2017 - 01/2017
2	CalciumIBA 01/2016 - 03/2015
2	Hormones (Hormone)IBA 07/2015 - 04/2010
2	MucinsIBA 12/2013 - 07/2013
1	MutagensIBA 03/2023
1	colibactinIBA 03/2023
1	CholesterolIBA 11/2019
1	Triglycerides (Triacylglycerol)IBA 11/2019
1	Exonucleases (3' 5' Exonuclease)IBA 01/2018
1	NucleotidesIBA 11/2017
1	MicroRNAs (MicroRNA)IBA 01/2017
1	O-(6)-methylguanineIBA 12/2016
1	MethyltransferasesIBA 12/2016
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2016
1	Ibuprofen (Motrin)FDA LinkGeneric 09/2015
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 09/2015
1	Contraceptive Agents (Contraceptives)IBA 07/2015
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 03/2015
1	RNA Splice SitesIBA 06/2011
1	SmokeIBA 07/2010
1	SteroidsIBA 04/2010
1	Progesterone Receptors (Progesterone Receptor)IBA 04/2010
1	Estrogen ReceptorsIBA 04/2010
1	EpitopesIBA 01/2009
1	Coloring Agents (Dyes)IBA 01/2009
1	Transcobalamins (Transcobalamin II)IBA 02/2008

Therapy/Procedure

3	Ligation 02/2017 - 08/2008
2	Precision Medicine 02/2023 - 01/2020
1	Drug Therapy (Chemotherapy) 01/2017
1	Hysterectomy 07/2015