Paul A Clarke Selected Research

SRA737

1/2020

CHK1 Inhibition Is Synthetically Lethal with Loss of B-Family DNA Polymerase Function in Human Lung and Colorectal Cancer Cells.

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Paul A Clarke Research Topics

Disease

43	Neoplasms (Cancer) 01/2023 - 10/2003
7	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 10/2003
4	Glioblastoma (Glioblastoma Multiforme) 07/2017 - 07/2009
3	Colonic Neoplasms (Colon Cancer) 01/2023 - 05/2012
3	Carcinogenesis 01/2023 - 09/2008
3	Melanoma (Melanoma, Malignant) 01/2018 - 03/2007
3	Ovarian Neoplasms (Ovarian Cancer) 07/2012 - 04/2007
2	Neuroblastoma 11/2020 - 01/2016
2	Carcinoma (Carcinomatosis) 11/2013 - 07/2010
1	Adenocarcinoma 01/2023
1	Leukemia 01/2020
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2020
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2020
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2020
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2020
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2020
1	Chordoma 01/2019
1	Breast Neoplasms (Breast Cancer) 05/2017
1	Cardiovascular Diseases (Cardiovascular Disease) 12/2015
1	Ovarian Epithelial Carcinoma 01/2015
1	Urinary Bladder Neoplasms (Bladder Cancer) 10/2013
1	Esophageal Neoplasms (Esophageal Cancer) 03/2011
1	Pathologic Processes 03/2010

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 01/2023 - 10/2003
9	Biomarkers (Surrogate Marker)IBA 01/2023 - 06/2007
8	Phosphotransferases (Kinase)IBA 01/2019 - 05/2013
8	PI103IBA 01/2017 - 06/2007
6	tanespimycin (17AAG)IBA 01/2023 - 10/2003
5	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2020 - 05/2017
5	Protein Isoforms (Isoforms)IBA 05/2017 - 09/2008
4	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2023 - 04/2007
4	Temozolomide (Temodar)FDA LinkGeneric 11/2020 - 02/2009
4	Phosphorylcholine (Phosphocholine)IBA 07/2017 - 07/2010
4	2- (1H- indazol- 4- yl)- 6- (4- methanesulfonylpiperazin- 1- ylmethyl)- 4- morpholin- 4- ylthieno(3,2- d)pyrimidineIBA 01/2015 - 09/2008
4	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 08/2013 - 09/2008
3	Molecular Chaperones (Chaperone, Molecular)IBA 01/2023 - 09/2008
3	Transcription Factors (Transcription Factor)IBA 01/2023 - 01/2019
3	Lactic Acid (Lactate)FDA LinkGeneric 07/2017 - 01/2014
3	MTOR InhibitorsIBA 07/2017 - 01/2016
3	Choline (Choline Chloride)IBA 01/2017 - 07/2010
3	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2014 - 07/2010
2	CYC065IBA 11/2020 - 01/2020
2	Oncogene Proteins (Oncogene Protein)IBA 01/2020 - 01/2016
2	Drug CombinationsIBA 01/2019 - 05/2012
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2019 - 01/2018
2	Mediator ComplexIBA 02/2016 - 12/2015
2	Protein Kinases (Protein Kinase)IBA 05/2014 - 09/2008
2	Protons (Proton)IBA 01/2014 - 07/2010
2	Phosphorus (Red Phosphorus)IBA 01/2014 - 07/2010
2	DNA (Deoxyribonucleic Acid)IBA 01/2014 - 05/2012
2	LigandsIBA 10/2013 - 08/2013
2	RNA (Ribonucleic Acid)IBA 03/2011 - 10/2003
2	Cytotoxins (Cytolysins)IBA 06/2009 - 02/2009
2	Proteasome Endopeptidase Complex (Proteasome)IBA 02/2009 - 09/2008
1	CCT251236IBA 01/2023
1	Adrenergic Agents (Adrenergic Drugs)IBA 11/2020
1	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 01/2020
1	venetoclaxIBA 01/2020
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2020
1	SRA737IBA 01/2020
1	Proto-Oncogene Proteins c-bcl-2 (Proto Oncogene Proteins c bcl 2)IBA 01/2020
1	AphidicolinIBA 01/2020
1	Serine (L-Serine)FDA Link 01/2020
1	RNA Polymerase II (RNA Polymerase B)IBA 01/2020
1	Brachyury protein (Brachyury)IBA 01/2019
1	RoscovitineIBA 01/2018
1	Antineoplastic Agents (Antineoplastics)IBA 01/2018
1	Complement System Proteins (Complement)IBA 01/2018
1	purineIBA 01/2018
1	Caspase 3 (Caspase-3)IBA 07/2017
1	Messenger RNA (mRNA)IBA 07/2017
1	dactolisibIBA 07/2017
1	palbociclibIBA 05/2017
1	Cyclin-Dependent Kinase 8IBA 02/2016
1	N-Myc Proto-Oncogene ProteinIBA 01/2016
1	CCT251545IBA 12/2015
1	idelalisibIBA 08/2015
1	PlatinumIBA 01/2015
1	Ribosomal Proteins (Ribosomal Protein)IBA 01/2015
1	Cullin Proteins (Cullins)IBA 05/2014
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 05/2014
1	Small Interfering RNA (siRNA)IBA 05/2014
1	Ligases (Synthetase)IBA 05/2014
1	OxadiazolesIBA 10/2013
1	benzimidazoleIBA 10/2013
1	trans-sodium crocetinate (crocetin)IBA 10/2013
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 10/2013
1	Therapeutic UsesIBA 05/2013
1	Adenosine Triphosphate (ATP)IBA 05/2013
1	Choline KinaseIBA 05/2012
1	Death Domain ReceptorsIBA 05/2012
1	ProteomeIBA 04/2012
1	Complementary DNA (cDNA)IBA 03/2011
1	thienopyrimidineIBA 03/2010
1	EnzymesIBA 03/2010

Therapy/Procedure

13	Therapeutics 11/2020 - 10/2003
3	Drug Therapy (Chemotherapy) 07/2012 - 03/2011
2	Radiotherapy 07/2017 - 01/2014
1	Oral Administration 10/2016
1	Precision Medicine 08/2015