Y Chen Selected Research

Immunotherapy

11/2023	[Efficacy of adjuvant programmed cell death 1 (PD-1) monoclonal antibody immunotherapy in Chinese patients with resected stage Ⅱ-Ⅲ melanoma].
12/2022	Clinical efficacy of targeted therapy, immunotherapy combined with hepatic artery infusion chemotherapy (FOLFOX), and lipiodol embolization in the treatment of unresectable hepatocarcinoma.
8/2022	[Incidence and risk factors of thromboembolism in patients with lung cancer receiving immunotherapy].
1/2021	Immune checkpoint inhibitors and cellular treatment for lymphoma immunotherapy.
1/2019	Safety, efficacy and tumor mutational burden as a biomarker of overall survival benefit in chemo-refractory gastric cancer treated with toripalimab, a PD-1 antibody in phase Ib/II clinical trial NCT02915432.
10/2013	Potent CD4+ T-cell epitope P30 enhances HER2/neu-engineered dendritic cell-induced immunity against Tg1-1 breast cancer in transgenic FVBneuN mice by enhanced CD4+ T-cell-stimulated CTL responses.
7/2011	Adjuvant effect of HER-2/neu-specific adenoviral vector stimulating CD8⁺ T and natural killer cell responses on anti-HER-2/neu antibody therapy for well-established breast tumors in HER-2/neu transgenic mice.
1/2007	PD-L1 expression analysis in gastric carcinoma tissue and blocking of tumor-associated PD-L1 signaling by two functional monoclonal antibodies.
1/2007	HLA-A2.1-restricted T cells react to SEREX-defined tumor antigen CML66L and are suppressed by CD4+CD25+ regulatory T cells.
4/2006	Characterization and application of two novel monoclonal antibodies against human OX40: costimulation of T cells and expression on tumor as well as normal gland tissues.

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Y Chen Research Topics

Disease

277	Neoplasms (Cancer) 12/2023 - 01/2000
72	Infections 02/2024 - 01/2000
62	Inflammation (Inflammations) 04/2024 - 01/2000
37	Breast Neoplasms (Breast Cancer) 05/2023 - 05/2000
32	Neoplasm Metastasis (Metastasis) 11/2023 - 01/2000
32	Carcinoma (Carcinomatosis) 01/2020 - 02/2000
27	Hepatocellular Carcinoma (Hepatoma) 11/2023 - 02/2000
27	Lung Neoplasms (Lung Cancer) 08/2022 - 01/2000
26	Carcinogenesis 07/2023 - 08/2001
25	Pain (Aches) 04/2024 - 01/2000
25	Hypoxia (Hypoxemia) 11/2023 - 01/2001
24	Fibrosis (Cirrhosis) 10/2023 - 01/2000
24	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 06/2000
23	Necrosis 04/2024 - 06/2000
22	Wounds and Injuries (Trauma) 04/2024 - 04/2000
22	Type 2 Diabetes Mellitus (MODY) 01/2021 - 03/2000
20	Stroke (Strokes) 08/2022 - 02/2000
19	Colorectal Neoplasms (Colorectal Cancer) 10/2023 - 08/2000
18	Body Weight (Weight, Body) 10/2023 - 08/2000
18	Hemorrhage 05/2023 - 06/2000
18	Asthma (Bronchial Asthma) 02/2022 - 07/2000
16	Hypertension (High Blood Pressure) 11/2021 - 11/2000
15	Melanoma (Melanoma, Malignant) 11/2023 - 03/2000
15	Ischemia 04/2021 - 06/2000
15	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 12/2000
14	Sepsis (Septicemia) 03/2024 - 02/2001
14	Burns 01/2021 - 04/2000
14	Leukemia 02/2018 - 01/2000
13	Thrombosis (Thrombus) 12/2023 - 03/2000
13	Myocardial Infarction 04/2023 - 04/2001
13	Stomach Neoplasms (Stomach Cancer) 06/2022 - 10/2000
13	Atherosclerosis 11/2021 - 01/2000
13	Mitochondrial Diseases (Mitochondrial Disease) 10/2020 - 02/2001
13	Obesity 05/2020 - 09/2000
11	COVID-19 11/2023 - 04/2020
11	Heart Failure 12/2022 - 06/2000
11	Hypersensitivity (Allergy) 02/2022 - 01/2001
11	Nasopharyngeal Carcinoma 12/2021 - 07/2001
11	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2020 - 06/2000
10	Cardiovascular Diseases (Cardiovascular Disease) 10/2023 - 03/2010
10	Ovarian Neoplasms (Ovarian Cancer) 08/2022 - 09/2010
10	Proteinuria 10/2021 - 03/2001
10	Adenocarcinoma 08/2021 - 06/2000
10	Lymphoma (Lymphomas) 01/2021 - 03/2001
10	Insulin Resistance 01/2020 - 03/2000
9	Liver Diseases (Liver Disease) 06/2023 - 05/2001
9	Chronic Obstructive Pulmonary Disease (COPD) 02/2023 - 08/2000

Drug/Important Bio-Agent (IBA)

123	Proteins (Proteins, Gene)FDA Link 11/2023 - 01/2000
51	Messenger RNA (mRNA)IBA 07/2023 - 01/2000
46	CytokinesIBA 07/2023 - 01/2000
33	DNA (Deoxyribonucleic Acid)IBA 12/2021 - 02/2000
25	Biomarkers (Surrogate Marker)IBA 11/2023 - 04/2000
23	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2023 - 04/2000
21	Therapeutic UsesIBA 10/2023 - 01/2000
20	Long Noncoding RNAIBA 01/2024 - 01/2016
19	VaccinesIBA 08/2023 - 11/2000
18	AntigensIBA 03/2023 - 01/2000
18	RNA (Ribonucleic Acid)IBA 02/2023 - 02/2001
18	MicroRNAs (MicroRNA)IBA 01/2023 - 07/2007
18	Peptides (Polypeptides)IBA 04/2022 - 01/2001
18	EnzymesIBA 07/2021 - 07/2000
17	CholesterolIBA 07/2020 - 09/2000
15	CreatinineIBA 03/2024 - 06/2000
15	LipidsIBA 10/2023 - 03/2000
15	Glucose (Dextrose)FDA LinkGeneric 10/2023 - 09/2000
15	AntibodiesIBA 06/2021 - 03/2000
15	Small Interfering RNA (siRNA)IBA 09/2019 - 12/2006
15	Complementary DNA (cDNA)IBA 01/2016 - 02/2000
14	Oxygen (Dioxygen)IBA 02/2024 - 01/2001
14	Blood Glucose (Blood Sugar)IBA 10/2023 - 08/2000
14	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2023 - 01/2003
14	Anti-Bacterial Agents (Antibiotics)IBA 10/2022 - 11/2000
14	Transcription Factors (Transcription Factor)IBA 06/2022 - 06/2000
14	Phosphotransferases (Kinase)IBA 02/2022 - 06/2006
14	Interleukin-6 (Interleukin 6)IBA 12/2021 - 03/2001
13	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 08/2000
12	NF-kappa B (NF-kB)IBA 04/2024 - 01/2000
12	CollagenIBA 06/2023 - 08/2000
11	Caspase 3 (Caspase-3)IBA 01/2024 - 04/2010
11	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2023 - 07/2001
11	salicylhydroxamic acid (SHAM)IBA 12/2022 - 04/2000
11	LigandsIBA 01/2021 - 04/2000
11	Insulin (Novolin)FDA Link 01/2020 - 03/2000
10	InterleukinsIBA 10/2023 - 04/2010
10	Retinaldehyde (Retinal)IBA 01/2023 - 09/2000
10	IronIBA 01/2023 - 05/2000
10	Hormones (Hormone)IBA 12/2022 - 06/2001
10	Paclitaxel (Taxol)FDA LinkGeneric 12/2021 - 01/2001
10	Adenosine Triphosphate (ATP)IBA 10/2020 - 06/2000
10	AcidsIBA 11/2018 - 07/2000
9	Apolipoproteins E (ApoE)IBA 01/2024 - 05/2000
9	LipopolysaccharidesIBA 12/2023 - 05/2001

Therapy/Procedure

112	Therapeutics 01/2024 - 01/2000
41	Drug Therapy (Chemotherapy) 12/2023 - 01/2000
24	Transplantation 02/2024 - 09/2004
21	Aftercare (After-Treatment) 10/2023 - 04/2000
21	Radiotherapy 01/2020 - 01/2000
19	Hematopoietic Stem Cell Transplantation 02/2024 - 08/2005
13	Immunotherapy 11/2023 - 07/2000
10	Length of Stay 12/2023 - 06/2007