Guan Chen Selected Research

Neoplasms (Cancer)

1/2023	p38γ MAPK Inflammatory and Metabolic Signaling in Physiology and Disease.
7/2018	Editorial Preface for Targeted Cancer Therapy.
7/2018	Targeting an oncogenic kinase/phosphatase signaling network for cancer therapy.
1/2017	The K-Ras effector p38γ MAPK confers intrinsic resistance to tyrosine kinase inhibitors by stimulating EGFR transcription and EGFR dephosphorylation.
6/2014	Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer.
7/2012	MK2 Regulates Ras Oncogenesis through Stimulating ROS Production.
10/2011	Phosphorylation and stabilization of topoisomerase IIα protein by p38γ mitogen-activated protein kinase sensitize breast cancer cells to its poisons.
4/2010	PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction.
8/2008	Experience of a large series of mastoscopic axillary lymph node dissection.
5/2008	The p38 MAPK stress pathway as a tumor suppressor or more?

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Guan Chen Research Topics

Disease

13	Neoplasms (Cancer) 01/2023 - 05/2004
9	Breast Neoplasms (Breast Cancer) 05/2015 - 07/2002
6	Colonic Neoplasms (Colon Cancer) 05/2024 - 05/2004
4	Carcinogenesis 01/2022 - 07/2012
3	Chronic Renal Insufficiency 05/2024 - 03/2021
3	Inflammation (Inflammations) 05/2024 - 03/2021
1	Pain (Aches) 07/2021
1	Chronic Kidney Disease-Mineral and Bone Disorder (Renal Rickets) 07/2021

Drug/Important Bio-Agent (IBA)

5	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2023 - 04/2010
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2005
5	Mitogen-Activated Protein KinasesIBA 01/2022 - 08/2006
4	Estrogen ReceptorsIBA 01/2014 - 02/2004
3	Protein Isoforms (Isoforms)IBA 01/2022 - 02/2003
3	Phosphotransferases (Kinase)IBA 01/2022 - 05/2004
3	p38 Mitogen-Activated Protein KinasesIBA 01/2022 - 05/2004
2	Non-Receptor Type 3 Protein Tyrosine PhosphataseIBA 05/2015 - 01/2014
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 07/2012 - 02/2003
2	Protein Kinases (Protein Kinase)IBA 07/2012 - 07/2002
2	Estrogens (Estrogen)FDA Link 04/2012 - 08/2006
2	arseniteIBA 05/2004 - 02/2003
2	Calcitriol Receptors (Calcitriol Receptor)IBA 05/2004 - 07/2002
1	NF-kappa B (NF-kB)IBA 05/2024
1	Adenine FDA LinkGeneric 05/2024
1	CreatineIBA 05/2024
1	LipopolysaccharidesIBA 05/2024
1	MineralsIBA 07/2021
1	TabletsIBA 07/2021
1	Cisplatin (Platino)FDA LinkGeneric 03/2021
1	AcidsIBA 03/2021
1	Therapeutic UsesIBA 03/2021
1	Glucose Transporter Type 2IBA 01/2020
1	ErbB Receptors (EGF Receptor)IBA 01/2017
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 05/2015
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 05/2015
1	Tyrosine Kinase InhibitorsIBA 05/2015
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 06/2014
1	Tamoxifen FDA LinkGeneric 01/2014
1	Tyrosine (L-Tyrosine)FDA Link 01/2014
1	Fulvestrant (Faslodex)FDA Link 01/2014
1	Estrogen Receptor Modulators (Antiestrogen)IBA 01/2014
1	ras ProteinsIBA 08/2012
1	AntioxidantsIBA 07/2012
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 07/2012
1	Reactive Oxygen Species (Oxygen Radicals)IBA 07/2012
1	Hormones (Hormone)IBA 04/2012
1	PoisonsIBA 10/2011
1	Paclitaxel (Taxol)FDA LinkGeneric 10/2011
1	Type II DNA Topoisomerases (Topoisomerase II)IBA 10/2011
1	trioctyl phosphine oxide (TOPO)IBA 10/2011
1	Chemokine ReceptorsIBA 04/2006
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 02/2004
1	Mitogen-Activated Protein Kinase 13IBA 02/2003
1	SteroidsIBA 07/2002
1	VitaminsIBA 07/2002

Therapy/Procedure

6	Therapeutics 07/2018 - 05/2004
2	Surgical Instruments (Clip) 08/2008 - 06/2005
1	Chinese Traditional Medicine (Traditional Chinese Medicine) 05/2024
1	Nephrectomy 07/2021
1	Lymph Node Excision (Lymph Node Dissection) 06/2005