Keefe T Chan Selected Research

Breast Neoplasms (Breast Cancer)

12/2023	INX-315, a Selective CDK2 Inhibitor, Induces Cell Cycle Arrest and Senescence in Solid Tumors.
1/2019	Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.
1/2017	The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer.
11/2015	β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.
4/2009	FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion.
3/2008	Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.

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Keefe T Chan Research Topics

Disease

13	Neoplasms (Cancer) 12/2023 - 10/2014
6	Breast Neoplasms (Breast Cancer) 12/2023 - 03/2008
3	Melanoma (Melanoma, Malignant) 01/2019 - 10/2014
2	Ovarian Neoplasms (Ovarian Cancer) 01/2021 - 01/2020
1	Stomach Neoplasms (Stomach Cancer) 01/2022
1	Hematologic Neoplasms (Hematological Malignancy) 11/2020
1	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 01/2020
1	Prostatic Neoplasms (Prostate Cancer) 01/2017
1	Neoplasm Metastasis (Metastasis) 11/2015
1	Nevus (Nevi) 05/2015

Drug/Important Bio-Agent (IBA)

5	CX 5461IBA 01/2021 - 08/2016
2	CystathionineIBA 01/2022 - 01/2018
2	RNA Polymerase I (Polymerase I, RNA)IBA 01/2021 - 11/2020
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2020 - 01/2016
1	ChromatinIBA 12/2023
1	Cyclin-Dependent Kinase 2IBA 12/2023
1	Retinoblastoma ProteinIBA 12/2023
1	DNA (Deoxyribonucleic Acid)IBA 11/2020
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2020
1	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 01/2019
1	palbociclibIBA 01/2019
1	Estrogen ReceptorsIBA 01/2019
1	Cyclin-Dependent Kinase 4IBA 01/2019
1	HomocysteineIBA 01/2018
1	Biomarkers (Surrogate Marker)IBA 01/2018
1	Ribosomal RNAIBA 01/2017
1	Adrenergic Agents (Adrenergic Drugs)IBA 11/2015
1	Adrenergic Receptors (Adrenergic Receptor)IBA 11/2015
1	Neurotransmitter Agents (Neurotransmitter)IBA 11/2015
1	Small Interfering RNA (siRNA)IBA 05/2015
1	Monoclonal AntibodiesIBA 05/2015
1	Formaldehyde (Formol)FDA Link 05/2015
1	Interleukin-2 (IL2)IBA 05/2015
1	ParaffinIBA 05/2015
1	Proteins (Proteins, Gene)FDA Link 05/2015
1	Messenger RNA (mRNA)IBA 05/2015
1	emt protein-tyrosine kinase (IL2-inducible T-cell kinase)IBA 05/2015
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 10/2014
1	Tyrosine (L-Tyrosine)FDA Link 04/2009
1	Focal Adhesion Protein-Tyrosine KinasesIBA 04/2009
1	CalpainIBA 03/2008
1	Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA 03/2008

Therapy/Procedure

3	Therapeutics 12/2023 - 11/2020