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Joan S Brugge Selected Research

cobimetinib

1/2019Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness.

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Joan S Brugge Research Topics

Disease

60Neoplasms (Cancer)
03/2024 - 10/2002
18Breast Neoplasms (Breast Cancer)
01/2022 - 05/2004
7Neoplasm Metastasis (Metastasis)
11/2020 - 06/2004
7Ovarian Neoplasms (Ovarian Cancer)
01/2019 - 07/2011
6Carcinogenesis
11/2018 - 06/2004
4Carcinoma (Carcinomatosis)
11/2020 - 07/2003
3Lung Neoplasms (Lung Cancer)
11/2022 - 12/2007
3Triple Negative Breast Neoplasms
01/2022 - 11/2020
2Residual Neoplasm
01/2021 - 01/2017
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
03/2024
1Endometrial Neoplasms (Endometrial Cancer)
01/2023
1Ascites
11/2020
1Polyploidy
01/2019
1Starvation
10/2017
1Ovarian Epithelial Carcinoma
03/2017
1Noninfiltrating Intraductal Carcinoma (DCIS)
01/2017
1Cysts
07/2010

Drug/Important Bio-Agent (IBA)

13Proteins (Proteins, Gene)FDA Link
01/2021 - 09/2005
5Phenobarbital (Luminal)FDA Link
01/2023 - 10/2002
5ErbB Receptors (EGF Receptor)IBA
11/2020 - 02/2004
5IntegrinsIBA
02/2012 - 11/2007
4navitoclaxIBA
03/2024 - 01/2019
4Immunoconjugates (Immunoconjugate)IBA
01/2023 - 01/2017
4Phosphotransferases (Kinase)IBA
11/2022 - 10/2010
4Messenger RNA (mRNA)IBA
01/2021 - 12/2005
4Lapatinib (GW572016)FDA Link
01/2021 - 01/2017
3DNA (Deoxyribonucleic Acid)IBA
03/2024 - 11/2020
3Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
03/2024 - 06/2004
3Transcription Factors (Transcription Factor)IBA
12/2020 - 12/2005
3LigandsIBA
07/2014 - 04/2004
2Hormones (Hormone)IBA
01/2022 - 10/2011
2Trastuzumab (Herceptin)FDA Link
01/2021 - 11/2020
2AntioxidantsIBA
01/2021 - 01/2019
2Estrogen ReceptorsIBA
01/2021 - 06/2013
2LuciferasesIBA
11/2020 - 09/2005
2Reactive Oxygen Species (Oxygen Radicals)IBA
11/2018 - 01/2016
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
10/2017 - 12/2005
2Laminin (Merosin)IBA
10/2017 - 01/2017
2Biomarkers (Surrogate Marker)IBA
03/2017 - 02/2010
2Glutamine (L-Glutamine)FDA Link
10/2016 - 01/2016
2Epidermal Growth Factor (EGF)IBA
01/2013 - 09/2007
2Myosins (Myosin)IBA
02/2012 - 07/2011
2Oncogene Proteins (Oncogene Protein)IBA
02/2010 - 06/2004
2CytokinesIBA
12/2007 - 09/2005
2Transforming Growth Factor beta (TGF-beta)IBA
05/2004 - 02/2004
1trametinibIBA
03/2024
1claudin 6IBA
01/2023
1AntigensIBA
01/2023
1RNA (Ribonucleic Acid)IBA
01/2022
1ProteomeIBA
01/2022
1InterferonsIBA
01/2022
1Fatty Acids (Saturated Fatty Acids)IBA
01/2021
1Progesterone Receptors (Progesterone Receptor)IBA
01/2021
1S63845IBA
01/2021
1Oxidants (Oxidizing Agents)IBA
12/2020
1ABT-414IBA
11/2020
1AmphiregulinIBA
11/2020
1cobimetinibIBA
01/2019
1Deubiquitinating EnzymesIBA
01/2019
1Glutathione (Reduced Glutathione)IBA
01/2019
12- (3- (4- ((2,6- dimethylmorpholino)methyl)styryl)- 1H- indazol- 6- yl)- 5'- methoxyspiro(cyclopropane- 1,3'- indolin)- 2'- oneIBA
01/2019
1PlatinumIBA
01/2019
1TRPA1 Cation ChannelIBA
11/2018
1Transaminases (Aminotransferases)IBA
10/2016
1SuspensionsIBA
01/2016
1A-factor (Streptomyces)IBA
06/2013
1Profilins (Profilin)IBA
11/2012
1Insulin (Novolin)FDA Link
03/2012
1Insulin-Like Growth Factor I (IGF-1)IBA
03/2012
1Green Fluorescent ProteinsIBA
02/2012
1Red Fluorescent ProteinIBA
02/2012
1human ERBB2 proteinIBA
10/2011
1IsotopesIBA
07/2011
1Glycine (Aminoacetic Acid)FDA LinkGeneric
07/2011
1Glucose (Dextrose)FDA LinkGeneric
07/2011
1CarbonIBA
07/2011
1Lactic Acid (Lactate)FDA LinkGeneric
07/2011
1Serine (L-Serine)FDA Link
07/2011
1Phosphoglycerate Dehydrogenase (Dehydrogenase, Phosphoglycerate)IBA
07/2011
1TalinIBA
07/2011
1Protein Tyrosine PhosphatasesIBA
03/2011
1tyrosine receptor (receptor, tyrosine)IBA
10/2010
1IGF Type 1 Receptor (IGF 1 Receptor)IBA
07/2010
1GTP-Binding Proteins (G-Protein)IBA
07/2010
1Cadherins (E-Cadherin)IBA
07/2010
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
07/2010
1Notch ReceptorsIBA
03/2010
1Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
12/2009
1Integrin beta1IBA
12/2009
1Protein-Lysine 6-Oxidase (Lysyl Oxidase)IBA
12/2009
1CollagenIBA
12/2009
1Staphylococcal Protein A (Protein A)IBA
12/2009

Therapy/Procedure

20Therapeutics
11/2022 - 05/2004
8Drug Therapy (Chemotherapy)
11/2020 - 10/2007
2Traction
02/2012 - 07/2011
1Heterologous Transplantation (Xenotransplantation)
01/2021
1Transplantation
11/2020
1Cytoreduction Surgical Procedures
01/2019
1Diet Therapy (Therapy, Diet)
10/2017
1Neoadjuvant Therapy
12/2016