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Brigid C Browne Selected Research

Trastuzumab (Herceptin)

1/2019HER-targeted tyrosine kinase inhibitors enhance response to trastuzumab and pertuzumab in HER2-positive breast cancer.
10/2018Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL.
6/2017Dual inhibition of IGF1R and ER enhances response to trastuzumab in HER2 positive breast cancer cells.
6/2014PP2A inhibition overcomes acquired resistance to HER2 targeted therapy.
12/2012Evaluation of IGF1R and phosphorylated IGF1R as targets in HER2-positive breast cancer cell lines and tumours.
6/2010Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib.

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Brigid C Browne Research Topics

Disease

11Breast Neoplasms (Breast Cancer)
02/2019 - 06/2010
7Neoplasms (Cancer)
06/2017 - 11/2010

Drug/Important Bio-Agent (IBA)

6Trastuzumab (Herceptin)FDA Link
01/2019 - 06/2010
4Tyrosine Kinase InhibitorsIBA
02/2019 - 12/2012
3Lapatinib (GW572016)FDA Link
10/2018 - 06/2010
3Proteins (Proteins, Gene)FDA Link
11/2013 - 11/2010
3Phenobarbital (Luminal)FDA Link
11/2013 - 11/2010
2Biomarkers (Surrogate Marker)IBA
10/2018 - 07/2014
2TamoxifenFDA LinkGeneric
06/2017 - 11/2013
2Tyrosine (L-Tyrosine)FDA Link
11/2013 - 11/2010
2Phosphotransferases (Kinase)IBA
03/2013 - 11/2010
2src-Family KinasesIBA
03/2013 - 11/2010
1AfatinibIBA
01/2019
1pertuzumabIBA
01/2019
1obatoclaxIBA
10/2018
1Estrogens (Estrogen)FDA Link
11/2013
1rho GTPase-activating proteinIBA
01/2011
1ErbB Receptors (EGF Receptor)IBA
11/2010
1human ERBB2 proteinIBA
06/2010

Therapy/Procedure

6Therapeutics
02/2019 - 06/2010
1Drug Therapy (Chemotherapy)
06/2017