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J David Brook Selected Research

Proteins (Proteins, Gene)

11/2019HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1.
3/2012Combined mutation screening of NKX2-5, GATA4, and TBX5 in congenital heart disease: multiple heterozygosity and novel mutations.
1/2009Muscleblind-like proteins: similarities and differences in normal and myotonic dystrophy muscle.
11/2006Flies deficient in Muscleblind protein model features of myotonic dystrophy with altered splice forms of Z-band associated transcripts.
4/2005Mutation in myosin heavy chain 6 causes atrial septal defect.

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J David Brook Research Topics

Disease

9Myotonic Dystrophy (Dystrophia Myotonica)
01/2020 - 04/2002
5Congenital Heart Defects (Congenital Heart Defect)
01/2017 - 04/2005
3Holt-Oram syndrome
11/2019 - 04/2003
2Tetralogy of Fallot (Fallot Tetralogy)
04/2012 - 01/2009
1Muscle Weakness
01/2019
1Genetic Translocation (Chromosomal Translocation)
01/2014
1Cardiomegaly (Heart Hypertrophy)
06/2009
1Muscular Diseases (Myopathy)
11/2006
1Atrial Heart Septal Defects (Atrial Septal Defect)
04/2005
1DiGeorge Syndrome (Syndrome, DiGeorge)
04/2003
1Cleft Palate with Ankyloglossia
04/2003
1Ulnar-mammary syndrome
04/2003

Drug/Important Bio-Agent (IBA)

5Proteins (Proteins, Gene)FDA Link
11/2019 - 04/2005
3RNA (Ribonucleic Acid)IBA
01/2020 - 11/2011
2Protein Kinases (Protein Kinase)IBA
01/2020 - 01/2019
2Transcription Factors (Transcription Factor)IBA
11/2019 - 04/2005
2Biomarkers (Surrogate Marker)IBA
01/2019 - 12/2018
2DNA (Deoxyribonucleic Acid)IBA
01/2017 - 04/2002
13' Untranslated Regions (3' UTR)IBA
01/2020
1RNA Splicing FactorsIBA
01/2019
1Circular RNAIBA
01/2019
1TropomyosinIBA
01/2017
1CELF1 ProteinIBA
03/2014
1RNA Splice SitesIBA
01/2014
1Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA
08/2013
1Ventricular MyosinsIBA
06/2009
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2009
1Messenger RNA (mRNA)IBA
09/2007
1Protein Isoforms (Isoforms)IBA
11/2006
1Myosin Heavy Chains (Myosin Heavy Chain)IBA
04/2005
1Adrenocorticotropic Hormone (ACTH)FDA Link
04/2003

Therapy/Procedure

1Ligation
04/2012