J H Beijnen Selected Research

Proteins (Proteins, Gene)

1/2022	Metabolic Disposition of Lurbinectedin, a Potent Selective Inhibitor of Active Transcription of Protein-Coding Genes, in Nonclinical Species and Patients.
10/2013	P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387.
6/2013	Is combination therapy the next step to overcome resistance and reduce toxicities in melanoma?
7/2010	Two-protein signature of novel serological markers apolipoprotein-A2 and serum amyloid alpha predicts prognosis in patients with metastatic renal cell cancer and improves the currently used prognostic survival models.
9/2004	Therapeutic drug monitoring of non-anticancer drugs in cancer patients.
7/2002	Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.
6/2002	Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer.
4/2001	Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.
1/2001	Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy.
10/2000	Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.

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J H Beijnen Research Topics

Disease

94	Neoplasms (Cancer) 09/2022 - 01/2000
22	Breast Neoplasms (Breast Cancer) 02/2021 - 01/2000
10	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 10/2000
9	Neutropenia 07/2015 - 04/2000
8	Melanoma (Melanoma, Malignant) 01/2023 - 10/2008
7	Ovarian Neoplasms (Ovarian Cancer) 08/2006 - 01/2000
6	Sarcoma (Soft Tissue Sarcoma) 07/2020 - 06/2000
6	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 09/2002
6	Colorectal Neoplasms (Colorectal Cancer) 01/2019 - 05/2000
5	Neoplasm Metastasis (Metastasis) 03/2016 - 05/2001
4	Disease Progression 01/2022 - 04/2002
4	Lymphoma (Lymphomas) 07/2018 - 06/2001
4	Non-Hodgkin Lymphoma (Lymphosarcoma) 12/2012 - 02/2007
4	Infections 04/2012 - 12/2001
4	Vomiting 06/2007 - 06/2000
4	Nausea 06/2007 - 06/2000
3	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2022 - 06/2001
3	Renal Cell Carcinoma (Grawitz Tumor) 07/2020 - 07/2010
3	Stomach Neoplasms (Stomach Cancer) 12/2017 - 02/2003
3	Leishmaniasis 02/2017 - 12/2006
3	Carcinoma (Carcinomatosis) 10/2014 - 06/2002
3	Rheumatoid Arthritis 01/2011 - 09/2000
3	Thrombocytopenia (Thrombopenia) 11/2005 - 12/2000
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2020 - 06/2000
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2017 - 08/2016
2	Glioma (Gliomas) 03/2016 - 07/2001
2	Hyperbilirubinemia 01/2014 - 07/2006
2	Colonic Neoplasms (Colon Cancer) 09/2013 - 09/2010
2	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 12/2012 - 01/2010

Drug/Important Bio-Agent (IBA)

26	Paclitaxel (Taxol)FDA LinkGeneric 10/2014 - 01/2000
12	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2000
12	Antineoplastic Agents (Antineoplastics)IBA 07/2015 - 03/2001
9	Cisplatin (Platino)FDA LinkGeneric 04/2015 - 11/2000
9	Carboplatin (JM8)FDA LinkGeneric 09/2006 - 10/2000
8	PlatinumIBA 01/2022 - 06/2002
7	Docetaxel (Taxotere)FDA Link 10/2014 - 04/2000
6	Tamoxifen FDA LinkGeneric 11/2018 - 08/2009
6	Gemcitabine FDA Link 12/2015 - 11/2005
6	TrabectedinIBA 04/2010 - 12/2000
6	Topotecan (Hycamtin)FDA LinkGeneric 03/2009 - 01/2000
6	Cyclosporine (Ciclosporin)FDA LinkGeneric 10/2007 - 07/2000
5	Adenosine Triphosphate (ATP)IBA 01/2019 - 01/2000
5	Capecitabine (Xeloda)FDA Link 12/2017 - 01/2014
5	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2014 - 10/2000
5	Rituximab (Mabthera)FDA Link 12/2012 - 01/2010
5	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2005 - 06/2001
4	niraparibIBA 01/2018 - 01/2017
4	Fluorouracil (Carac)FDA LinkGeneric 12/2017 - 05/2001
4	miltefosine (Impavido)IBA 02/2017 - 12/2006
4	eribulin FDA Link 07/2015 - 12/2012
4	Oxaliplatin (Eloxatin)FDA LinkGeneric 04/2015 - 08/2005
4	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 10/2013 - 06/2000
4	Thiotepa (Triethylenethiophosphoramide)FDA LinkGeneric 11/2002 - 01/2001
4	kahalalide FIBA 09/2002 - 07/2001
4	cremophor ELIBA 11/2001 - 07/2000
4	Ifosfamide FDA LinkGeneric 09/2001 - 06/2000
3	dabrafenibIBA 01/2023 - 06/2016
3	trametinibIBA 01/2023 - 06/2016
3	Poly(ADP-ribose) Polymerase InhibitorsIBA 02/2021 - 01/2017
3	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 02/2021 - 01/2017
3	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2021 - 03/2012
3	4-hydroxy-N-desmethyltamoxifenIBA 11/2018 - 04/2013
3	plitidepsin (aplidine)IBA 01/2018 - 05/2000
3	Epirubicin (Ellence)FDA LinkGeneric 04/2015 - 08/2001
3	taxaneIBA 04/2014 - 08/2006
3	Taxoids (Taxanes)IBA 04/2014 - 05/2001
3	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 07/2010 - 09/2001
3	Capsules (Microcapsules)IBA 04/2010 - 01/2002
3	BilirubinIBA 11/2007 - 09/2003
3	SolutionsIBA 10/2007 - 07/2000
3	Methotrexate (Mexate)FDA LinkGeneric 02/2007 - 06/2001
3	PolymersIBA 01/2007 - 11/2001
3	tipifarnib (R115777)IBA 11/2005 - 01/2002
3	Triethylenephosphoramide (TEPA)IBA 11/2002 - 01/2001
3	AndrogensIBA 09/2002 - 01/2001
3	ElacridarIBA 07/2002 - 01/2001
2	olaparibIBA 02/2021 - 12/2013
2	pazopanib FDA Link 07/2020 - 12/2017
2	Abiraterone AcetateIBA 01/2020 - 01/2017
2	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2019 - 01/2005
2	Estrogen ReceptorsIBA 11/2018 - 04/2013
2	enzalutamideIBA 04/2018 - 01/2017
2	vosaroxinIBA 01/2017 - 08/2016
2	VemurafenibIBA 01/2017 - 01/2014
2	QuinolonesIBA 01/2017 - 08/2016
2	Cytarabine (Cytosar-U)FDA LinkGeneric 08/2016 - 06/2001
2	Prostate-Specific Antigen (Semenogelase)IBA 07/2015 - 07/2015
2	ElectrolytesIBA 02/2015 - 11/2005
2	oseltamivir carboxylateIBA 05/2013 - 04/2012
2	Messenger RNA (mRNA)IBA 11/2011 - 06/2011
2	Biomarkers (Surrogate Marker)IBA 06/2011 - 01/2006
2	CD20 AntigensIBA 01/2011 - 01/2011
2	indibulinIBA 04/2010 - 06/2007

Therapy/Procedure

21	Drug Therapy (Chemotherapy) 01/2022 - 01/2000
11	Therapeutics 06/2016 - 01/2000
4	Castration 01/2020 - 07/2015
4	Oral Administration 10/2007 - 05/2001
3	Cytoreduction Surgical Procedures 02/2015 - 11/2000
3	Transplantation 03/2002 - 04/2000
2	Hyperthermic Intraperitoneal Chemotherapy 02/2015 - 05/2001