[Clinical application of autoantibody idiotypes].

Abstract

Idiotypes (Id) are unique antigenic determinants in hypervariable regions of immunoglobulins. This paper describes the clinical usefulness of Id for the determination of pathogenic autoantibodies. O-81-Id, human anti-DNA antibody idiotypes, were specifically detected in circulating and renal glomeruli-deposited immune complexes of patients with active lupus nephritis. Anti-idiotypic antibodies to anti-DNA antibodies could be also detected in human sera. Anti-Id antibodies to O-81-Id occurred spontaneously during the remission of systemic lupus erythematosus (SLE) but rarely during an acute episode. Monoclonal anti-Id antibodies had an ability to suppress in vitro anti-DNA antibody production by SLE lymphocytes. We also presented specific manipulation of anti-DNA production though the elimination of anti-DNA-Id-positive cells by using anti-Id-cytotoxic agent conjugates.

• Authors: T Sasaki
• Journal: Rinsho byori. The Japanese journal of clinical pathology (Rinsho Byori) Vol. 42 Issue 9 Pg. 925-8 (Sep 1994) ISSN: 0047-1860 [Print] Japan
• PMID: 7967116 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Antibodies, Anti-Idiotypic
• Antibodies, Antinuclear

Topics

• Animals
• Antibodies, Anti-Idiotypic
• Antibodies, Antinuclear (analysis, biosynthesis)
• Humans
• Lupus Erythematosus, Systemic (immunology, therapy)
• Lupus Nephritis (immunology, therapy)