Abstract | Aims: Methods: Results: HJ11 improved cardiac function and attenuated inflammation in rats with acute coronary syndrome. Relative to the untreated model group, the HJ11-treated group presented normalized Firmicutes/Bacteroidetes ratio and reduced abundances of the bacterial genera norank_f__Ruminococcaceae, Desulfovibrio, Clostridium_sensu_stricto_1, Adlercreutzia, Staphylococcus, Bacteroides, Prevotella, Rikenellaceae_RC9_gut_group, unclassified_o__Bacteroidales, and Ruminococcus_gauvreauii_group. We found 23 differentially expressed intestinal metabolites, and the enriched metabolic pathways were mainly related to amino acid metabolism. We also discovered that asymmetric dimethylarginine levels were strongly associated with cardiovascular disease. Correlation analyses revealed strong associations among intestinal microflora, their metabolites, proinflammatory factors, and cardiac function. Hence, the therapeutic effects of HJ11 on acute coronary syndrome are related to specific alterations in gut microbiota and their metabolites. Conclusion:
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Authors | Ning Zhao, Ying Wang, Yan Ma, Xiaoxue Liang, Xi Zhang, Yuan Gao, Yingying Dong, Dong Bai, Jingqing Hu |
Journal | Frontiers in cardiovascular medicine
(Front Cardiovasc Med)
Vol. 9
Pg. 1038273
( 2022)
ISSN: 2297-055X [Print] Switzerland |
PMID | 36684592
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 Zhao, Wang, Ma, Liang, Zhang, Gao, Dong, Bai and Hu. |
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