Paediatric and adult patients from New Caledonia Island admitted to the ICU for community-acquired Panton-Valentine leucocidin-producing Staphylococcus aureus infections.

Abstract

Severe infections involving Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL + Sa) are increasing. This monocentre, retrospective descriptive cohort assessed clinical characteristics and outcome of paediatric and adult patients admitted for community-acquired PVL + Sa infections to the unique intensive care unit (ICU) on New Caledonia Island. Overall, 72 patients (including 23 children) admitted for acute respiratory failure (42%), sepsis/septic shock (21%), and/or postoperative care (32%) were analysed. Most patients had pulmonary (64%), skin/soft tissue (SSTI) (54%) and/or osteoarticular (38%) infections. Multifocal infections (≥ 2 sites) and bacteraemia were reported in 65% and 76% of the patients, respectively. Methicillin-resistant S. aureus isolates were reported in 61% of adult cases versus 30% in children (p < 0.05). Mechanical ventilation, vasoactive support and source control were administered in 53%, 43% and 58% of the patients, respectively. All paediatric patients received adequate empirical antibiotic therapy versus 30/49 adults (p < 0.001). Adequate documented therapy was obtained ≤ 72 h in 70/72 (97%) patients. Death was only reported in adults (n = 10 (14%)), mainly during pulmonary infection (22%), SSTIs (21%) and bacteraemia (24%)). In summary, in ICU patients from New Caledonia Island the clinical presentation of severe community-acquired PVL + Sa infections seems different from Western European observations with high rates of multifocal infections and methicillin-resistant strains.

• Authors: O Imauven, J Colot, E Couadau, P-H Moury, A Preault, F Vincent, Philippe Montravers
• Journal: Scientific reports (Sci Rep) Vol. 12 Issue 1 Pg. 11024 (06 30 2022) ISSN: 2045-2322 [Electronic] England
• PMID: 35773383 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s).

Chemical References

• Bacterial Toxins
• Exotoxins
• Leukocidins

Topics

• Adult
• Bacteremia (drug therapy, epidemiology)
• Bacterial Toxins
• Child
• Community-Acquired Infections (epidemiology)
• Exotoxins
• Humans
• Intensive Care Units
• Leukocidins
• Methicillin-Resistant Staphylococcus aureus
• New Caledonia (epidemiology)
• Retrospective Studies
• Soft Tissue Infections
• Staphylococcal Infections (drug therapy, epidemiology)
• Staphylococcus aureus