Leukocidins (Leukocidin)

Pore forming proteins originally discovered for toxic activity to LEUKOCYTES. They are EXOTOXINS produced by some pathogenic STAPHYLOCOCCUS and STREPTOCOCCUS that destroy leukocytes by lysis of the cytoplasmic granules and are partially responsible for the pathogenicity of the organisms.

Also Known As:

Networked: 222 relevant articles (3 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Torres, Victor J: 10 articles (01/2022 - 01/2012)
2.	Vandenesch, François: 6 articles (10/2018 - 07/2005)
3.	Etienne, Jerome: 6 articles (07/2013 - 07/2005)
4.	Chan, Rita: 4 articles (01/2022 - 10/2018)
5.	Lina, Gerard: 4 articles (11/2020 - 07/2005)
6.	Diep, Binh An: 4 articles (01/2020 - 05/2004)
7.	Shopsin, Bo: 4 articles (01/2020 - 01/2012)
8.	Ehricht, Ralf: 4 articles (12/2019 - 11/2007)
9.	Monecke, Stefan: 4 articles (12/2019 - 11/2007)
10.	Vandenesch, F: 4 articles (11/2019 - 10/2007)

Related Diseases

1.	Necrotizing Pneumonia 01/01/2020 - "Staphylococcus aureus causes necrotizing pneumonia by secreting toxins such as leukocidins that target front-line immune cells. " 11/21/2019 - "Draft Genome Sequence of the Panton-Valentine Leucocidin-Producing Staphylococcus aureus Sequence Type 154 Strain NRL 08/001, Isolated from a Fatal Case of Necrotizing Pneumonia." 03/01/2019 - "Rapidly Progressive Multiple Cavity Formation in Necrotizing Pneumonia Caused by Community-acquired Methicillin-resistant Staphylococcus aureus Positive for the Panton-Valentine Leucocidin Gene." 03/01/2013 - "Staphylococcal necrotizing pneumonia (NP) is a severe disease associated with Panton-Valentine leucocidin (PVL). " 04/01/2008 - "These bacteria may produce Panton-Valentine leucocidin potentially leading to necrotizing pneumonia. "
2.	Infections 08/01/2015 - "This study offers directions for the development of improved preclinical models for infection, as well as for the design of drugs antagonizing leukocidin toxicity. " 02/06/2023 - "Panton Valentine leucocidin (PVL) genes were associated with higher biological inflammatory markers at presentation (n = 4 studies), more febrile days (n = 3), and more complicated/severe infection (n = 4). " 06/01/2005 - "In response to several isolations of methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leucocidin gene (PVL-MRSA), the present study was conducted to document the spread of infection in a small region of southeastern Germany. " 10/06/2023 - "While both SarS and Rot have been established as repressors of leukocidins, the importance of each repressor in infection is unclear. " 10/04/2023 - "S. aureus utilizes a family of pore-forming toxins, known as bi-component leukocidins, to evade the host immune response and promote infection. "
3.	Staphylococcal Infections 01/01/2010 - "The aim of this study was to determine the prevalence of bi-component leukocidin in Methicillin Resistant Staphylococcus aureus (MRSA) isolates in staphylococcal infections. " 01/01/2022 - "Severe Staphylococcus aureus infections in children: Case reports and management of positive Panton-Valentine leucocidin cases." 01/01/2022 - "Paediatric and adult patients from New Caledonia Island admitted to the ICU for community-acquired Panton-Valentine leucocidin-producing Staphylococcus aureus infections." 04/01/2011 - "Panton-Valentine leucocidin and severe Staphylococcus aureus infections of the skin: sole culprit or does it have accomplices?" 10/16/2009 - "Panton-Valentine leucocidin associated Staphylococcus aureus infections."
4.	Soft Tissue Infections 01/01/2021 - "Additionally, the study of CA-MRSA collected from communities and hospitals showed an increase in Panton-Valentine leucocidin (PVL)-positive CA-MRSA, causing severe skin and soft tissue infections. " 10/01/2020 - "Frequency Of Panton Valentine Leucocidin Gene In Staphylococcus Aureus From Skin And Soft Tissue Infections." 01/01/2017 - "High burden of complicated skin and soft tissue infections in the Indigenous population of Central Australia due to dominant Panton Valentine leucocidin clones ST93-MRSA and CC121-MSSA." 01/01/2015 - "Two-hundred MRSA strains from inpatients with healthcare-associated (HA) and 100 MRSA strains from outpatients with community-associated (CA) skin and soft tissue infections (SSTIs) were tested for antimicrobial susceptibility, staphylococcal cassette chromosome mec (SCCmec) typing, Panton-Valentine leucocidin (PVL) toxin, seh and arcA genes. " 04/01/2012 - "Panton-Valentine leucocidin gene carriage among Staphylococcus aureus strains recovered from skin and soft tissue infections in Turkey."
5.	Burns 03/01/2012 - "The prevalence of genes encoding leukocidins in Staphylococcus aureus strains resistant and sensitive to methicillin isolated from burn patients in Taleghani Hospital, Ahvaz, Iran." 11/01/2010 - "Over a 16 month period, 30 individuals (19 patients, one relative and 10 members of staff) on a regional burns and plastics unit became colonised or infected with a single strain of Panton-Valentine leucocidin-producing meticillin-resistant Staphylococcus aureus (PVL-MRSA). " 11/01/2010 - "Outbreak of Panton-Valentine leucocidin-positive meticillin-resistant Staphylococcus aureus in a regional burns unit." 10/01/2018 - "Last, chronic infection in a porcine burn wound model clearly demonstrated that leukocidins are required for "NETosis" and facilitate bacterial survival in vivo." 09/01/2022 - "This study aimed to investigate S. aureus from burn wound infections and those from the nose of HCWs in terms of antibiotic resistance, the presence of Panton-Valentine leucocidin-encoding gene (pvl) and the arginine catabolic mobile element (ACME), and the ability for biofilm formation. "

Related Drugs and Biologics

1.	Hemolysin Proteins (Hemolysins)
2.	Monoclonal Antibodies
3.	Enterotoxins (Enterotoxin)
4.	Elements
5.	Arginine (L-Arginine)
6.	spleen fibrinolytic proteinase (human) (SFP)
7.	Methicillin (Metin)
8.	Virulence Factors (Pathogenicity Factors)
9.	Exfoliatins
10.	Leukocidins (Leukocidin)

Related Therapies and Procedures

1.	Extracorporeal Membrane Oxygenation
2.	Therapeutics
3.	Membrane Oxygenators (Membrane Oxygenator)
4.	Intraperitoneal Injections
5.	Injections