aMMP-8 Oral Fluid PoC Test in Relation to Oral and Systemic Diseases.

Abstract

The manuscript uses the previously published literature and highlights the benefits of active-matrix metalloproteinase (aMMP)-8 chairside/point-of-care (PoC) diagnostic tools as adjunctive measures in oral and systemic diseases. Previous studies suggest that as a biomarker, aMMP-8 is more precise than total MMP-8, MMP-9, MMP-2, MMP-3, MMP-13, MMP-7, MMP-1, calprotectin, myeloperoxidase (MPO), human neutrophil elastase (HNE), tissue inhibitor of matrix metalloproteinase (TIMP)-1, and bleeding of probing (BOP). Therefore, aMMP-8 could be implemented as the needed key biomarker for the new disease classification for both periodontitis and peri-implantitis. With a sensitivity to the tune of 75-85% and specificity in the range of 80-90%, lateral flow aMMP-8 PoC testing is comparable to catalytic protease activity assays for aMMP-8. The test can be further applied to estimate the glycemic status of an individual, to ascertain whether a person is at risk for COVID-19, in managing the oral side effects of radiotherapy carried in head and neck cancers, and in selected cases pertaining to reproductive health. In the future, aMMP-8 could find application as a potential systemic biomarker in diseases affecting the cardiovascular system, cancers, bacteremia, sepsis, diabetes, obesity, meningitis, as well as pancreatitis. The aMMP-8 PoCT is the first practical test in the emerging new dental clinical field, that is, oral clinical chemistry representing oral medicine, clinical chemistry, peri-implantology, and periodontology.

• Authors: Timo Sorsa, Solomon Olusegun Nwhator, Dimitra Sakellari, Andreas Grigoriadis, Kehinde Adesola Umeizudike, Ella Brandt, Mutlu Keskin, Taina Tervahartiala, Pirjo Pärnänen, Shipra Gupta, Ritin Mohindra, Nagihan Bostanci, Nurcan Buduneli, Ismo Tapani Räisänen
• Journal: Frontiers in oral health (Front Oral Health) Vol. 3 Pg. 897115 ( 2022) ISSN: 2673-4842 [Electronic] Switzerland
• PMID: 35757444 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2022 Sorsa, Nwhator, Sakellari, Grigoriadis, Umeizudike, Brandt, Keskin, Tervahartiala, Pärnänen, Gupta, Mohindra, Bostanci, Buduneli and Räisänen.