Head and Neck Neoplasms (Head and Neck Cancer)

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4189 relevant articles (249 outcomes, 873 trials/studies) found for this Disease

Description: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)

Also Known As:

Head and Neck Cancer; Cancer of Head; Cancer of Neck; Cancer of the Head; Cancer of the Head and Neck; Cancer of the Neck; Head Neoplasms; Head, Neck Neoplasms; Neoplasms, Head; Neoplasms, Head and Neck; Neoplasms, Neck; UADT Neoplasms; Neoplasm, UADT; Neoplasms, UADT; UADT Neoplasm; Cancer of Head and Neck; Head Cancer; Neck Cancer; Neck Neoplasms; Neoplasms, Upper Aerodigestive Tract; Upper Aerodigestive Tract Neoplasms

Relationship Network

Disease Context: Research Results

Neoplasms: 387349

Neoplasms by Site: 1

Head and Neck Neoplasms: 4189

Thyroid Neoplasms: 6647

Esophageal Neoplasms: 3651

Mouth Neoplasms: 1492

Parathyroid Neoplasms: 1057

Facial Neoplasms: 8

Otorhinolaryngologic Neoplasms: 5

Tracheal Neoplasms: 5

Related Diseases

1.	Neoplasms (Cancer)
2.	Xerostomia
3.	Mucositis
4.	Carcinoma (Carcinomatosis)
5.	Neoplasm Metastasis (Metastasis)

Experts

1.	Eisbruch, Avraham: 13 articles (08/2007 - 05/2002)
2.	Vokes, Everett E: 12 articles (06/2008 - 01/2003)
3.	Argiris, Athanassios: 11 articles (03/2008 - 01/2003)
4.	Haraf, Daniel J: 10 articles (04/2008 - 01/2003)
5.	Grandis, Jennifer R: 9 articles (06/2008 - 09/2005)
6.	Posner, Marshall R: 9 articles (11/2007 - 01/2003)
7.	Bradford, Carol R: 8 articles (08/2008 - 05/2002)
8.	Vermorken, Jan B: 7 articles (09/2008 - 05/2005)
9.	Teknos, Theodoros N: 7 articles (08/2008 - 05/2002)
10.	Wolf, Gregory T: 7 articles (08/2008 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Head and Neck Neoplasms:

1.	Cisplatin (Platino)FDA LinkGeneric 01/01/2005 - "PURPOSE: The purpose of this study was to evaluate the efficacy of rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for previously untreated patients with advanced head and neck cancer" 06/01/2001 - "Cisplatin is a widely used chemotherapeutic agent in head and neck cancer, and is particularly effective in combination with radiation therapy" 07/01/1997 - "CONCLUSIONS: Accelerated twice-daily radiation with concurrent cisplatin is effective in locally advanced head and neck cancer and can be safely given with manageable toxicity." 01/15/1987 - "The authors concluded that the combination of cisplatin and radiotherapy is an effective and safe treatment in patients with advanced head and neck cancer and needs to be tested against radiotherapy alone." 02/01/1986 - "It is therefore concluded that cisplatin is markedly useful for the treatment of head and neck cancer." Order ALL the reference details at left...
2.	Fluorouracil (Carac)FDA LinkGeneric 02/01/1989 - "5-FU therapeutic monitoring with dose adjustment leads to an improved therapeutic index in head and neck cancer." 02/01/1991 - "The radiosensitization properties of 5-FU are well documented, and clinical trials have suggested improved local control and survival in head and neck cancer" 09/01/2005 - "Although we could not show a benefit in survival with the CDDP + 5-FU protocol, this trial supports literature data and confirms that this regimen may be proposed as a first-line therapy in advanced cancer of the head and neck." 12/01/2004 - "Phase II trial of hyperfractionated accelerated split-course radiochemotherapy with 5-FU and Cis-DDP in advanced head and neck cancer: results and toxicity." 11/30/2000 - "In collaboration with the FFCD and GERCOR, the EORTC will start an international multicenter randomized phase III study comparing high dose radiotherapy and concomitant continuous infusion of 5-FU versus control after pancreatico-duodenectomy for pancreatic head cancer (22995/40992)." Order ALL the reference details at left...
3.	Paclitaxel (Taxol)FDA LinkGeneric 02/01/1997 - "Since concomitant radiochemotherapy has proven to be beneficial for the treatment of locally advanced head and neck cancer, we are testing the feasibility of simultaneous paclitaxel plus radiotherapy" 06/01/2005 - "Paclitaxel is an anticancer agent effective for the treatment of breast, ovarian, lung, and head and neck cancer" 10/01/2000 - "These data suggest that paclitaxel may be effective for treating CDDP resistant head and neck cancer." 05/01/2005 - "Aim of the present study was to test, activity and toxicity of a rapidly alternating chemoradiation (paclitaxel based) in 31 patients with unresectable, locally advanced or recurrent after surgery, head and neck cancer" 12/01/2004 - "Final report of a pilot trial of accelerated radiotherapy plus concurrent 96-hour infusional paclitaxel for locally advanced head and neck cancer." Order ALL the reference details at left...
4.	docetaxel (Taxotere)FDA Link 03/01/1996 - "Docetaxel said to be highly effective and well tolerated in advanced head and neck cancer." 11/01/2005 - "OBJECTIVE: To examine the feasibility and efficacy of concurrent weekly docetaxel and radiation therapy as a definitive treatment for head and neck cancer (HNC)" 09/01/2006 - "BACKGROUND: This study was designed to evaluate the concomitant use of weekly docetaxel and hyperfractionated radiotherapy for the treatment of head and neck cancer (HNC)" 06/01/2006 - "A combination study of S-1 and docetaxel in patients with head and neck cancer]" 05/01/2005 - "End point of the study here presented is a preliminar assessment of toxicity and feasibility of concurrent radio-chemoterapy with docetaxel and cisplatinum in patients with head and neck cancer" Order ALL the reference details at left...
5.	Amifostine (Ethyol)FDA LinkGeneric 02/01/2006 - "OBJECTIVE: To assess the feasibility and efficacy of subcutaneous amifostine therapy in patients with head and neck cancer treated with curative accelerated radiotherapy (RT)" 02/01/2006 - "Feasibility and efficacy of subcutaneous amifostine therapy in patients with head and neck cancer treated with curative accelerated concomitant-boost radiation therapy." 12/01/2004 - "A phase II study to assess the efficacy of amifostine for submandibular/sublingual salivary sparing during the treatment of head and neck cancer with intensity modulated radiation therapy for parotid salivary sparing." 02/01/2007 - "A Phase II trial of subcutaneous amifostine and radiation therapy in patients with head-and-neck cancer." 08/01/2006 - "Radiotherapy alone, versus radiotherapy with amifostine 3 times weekly, versus radiotherapy with amifostine 5 times weekly: A prospective randomized study in squamous cell head and neck cancer." Order ALL the reference details at left...
6.	Carboplatin (JM8)FDA LinkGeneric 03/01/2008 - "Long-term results of a phase III randomized trial of postoperative radiotherapy with or without carboplatin in patients with high-risk head and neck cancer." 01/01/2007 - "BACKGROUND: This study evaluated the feasibility, toxicity, response rate and survival of neoadjuvant superselective intra-arterial infusion of high dose carboplatin in advanced head and neck cancer" 01/01/1993 - "Thirty-two patients with locally advanced head and neck cancer have been treated with concurrent weekly carboplatin and conventional radiation therapy (RT) (2 Gy fractions 4-5 days/week to a total dose of 64-70 Gy over 7-8 weeks) in a Phase I/II study" 01/01/1993 - "Phase I/II study of concurrent weekly carboplatin and radiation therapy in advanced head and neck cancer." 07/01/1992 - "Dose-finding study for hyperfractionated, accelerated radiotherapy plus simultaneous carboplatin administration in patients with locoregionally advanced head and neck cancer]" Order ALL the reference details at left...
7.	cetuximab (Erbitux)FDA Link 01/01/2006 - "Indeed, one of the more striking clinical results in this field has been recently achieved by combining an EGFR inhibitor (cetuximab) with radiation in the treatment of advanced head and neck cancer patients" 09/01/2004 - "Preclinical data provide proof-of-principle that local tumour control may be improved by combining irradiation with C225 mAb. In a randomised phase III clinical trial, simultaneous irradiation and treatment with the EGFR antibody Cetuximab (Erbitux; C225) in head and neck cancer patients resulted in significantly improved locoregional tumour control and survival compared to curative irradiation alone" 02/01/2008 - "BACKGROUND: The concurrent administration of cetuximab to radiotherapy has recently been shown to improve the clinical outcome of head-and-neck cancer (HNC) patients" 01/01/2008 - "It was found in a randomized landmark study that addition of cetuximab to radiotherapy significantly improves local control as well as overall survival of advanced stage head and neck cancer patients" 06/01/2007 - "In this paper, we report a review of the major studies dealing with the use of cetuximab in advanced head and neck cancer." Order ALL the reference details at left...
8.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/01/2004 - "It has to be stressed that PDT is still less effective in the treatment of more advanced cases of head and neck cancer" 11/01/1995 - "We feel there is now sufficient evident of the efficacy of this treatment to warrant a multicentre prospective study into the treatment of early head and neck cancer with PDT." 04/01/2007 - "To investigate the effect of sublethal PDT on the invasiveness of head and neck cancer cells and to elucidate the possible mechanisms, we initiated this study" 07/01/2003 - "CONCLUSIONS: This study confirms that PDT is a powerful treatment modality that could be considered as an alternative to surgery or radiotherapy in specific cases of head and neck cancer" 06/05/2006 - "The possibilities for PDT for head and neck cancer in Denmark are mentioned." Order ALL the reference details at left...
9.	Bleomycin (Blenoxane)FDA LinkGeneric 01/01/1993 - "In vitro protective effects of chemopreventive agents against bleomycin-induced genotoxicity in lymphoblastoid cell lines and peripheral blood lymphocytes of head and neck cancer patients." 03/01/1998 - "The aim of this study was to assess the feasibility of concurrent split course radiotherapy and low-dose bleomycin in the treatment of unresectable head and neck cancer with unfavourable prognostic factors and severe symptoms" 03/25/2001 - "Validity of chromosome analysis and bleomycin sensitivity assay in the prevention of head and neck cancer in Hungary]" 01/01/2001 - "However, bleomycin it is used to identify mutagen sensitive individuals, especially among head and neck cancer patients" 09/01/1998 - "The purpose of this paper is to introduce the concept of electroporation therapy and present our results from using this new technique combined with intralesional bleomycin in head and neck cancer patients" Order ALL the reference details at left...
10.	gemcitabine FDA Link 01/15/2006 - "Although the combination of gemcitabine and radiation produces a high frequency of complete responses in the treatment of locally advanced head and neck cancer, substantial toxicity suggests that an improvement in the therapeutic index is required" 05/01/2002 - "PATIENTS AND METHODS: Twenty-nine patients with nonresectable Stage IV head-and-neck cancer participated in a Phase I study of radiation, 70 Gy/7 weeks, concurrent with weekly gemcitabine" 02/01/2001 - "PURPOSE: To examine the feasibility and dose-limiting toxicity (DLT) of once-weekly gemcitabine at doses predicted in preclinical studies to produce radiosensitization, concurrent with a standard course of radiation for locally advanced head and neck cancer" 02/01/2001 - "Radiation concurrent with gemcitabine for locally advanced head and neck cancer: a phase I trial and intracellular drug incorporation study." 04/01/1997 - "These preclinical data were useful in the design of a gemcitabine dose escalation trial in combination with standard radiation for patients with unresectable head and neck cancer" Order ALL the reference details at left...

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 06/01/2005 - "BACKGROUND: Neoadjuvant chemotherapy has been reported to be extremely active in head and neck cancer but has failed to give a statistically significant improvement in survival" 01/01/2009 - "The addition of chemotherapy to radiation in the treatment of advanced-staged head and neck cancer has improved local-regional control and increased complete clinical and pathologic response rates in the neck" 03/01/2008 - "BACKGROUND: Although meta-analysis showed that survival improved with concurrent chemoradiation in locally advanced head and neck cancer, neoadjuvant chemotherapy is still unique, because it renders curative surgery feasible for marginally resectable head and neck cancer patients" 07/01/1991 - "A retrospective analysis was performed to investigate potential prognostic factors for complete remission to neoadjuvant chemotherapy and overall survival in patients with previously untreated stage III and stage IV head and neck cancer" 10/01/2006 - "Despite many advances in surgical techniques, technology, radiation therapy, and chemotherapy, survival rates for head and neck cancer (HNCa) have not improved significantly in decades, with many patients being diagnosed at advanced disease stages" Order ALL the reference details at left...
2.	Combination Drug Therapy (Combination Chemotherapy) 08/01/1985 - "Despite good results of polychemotherapy in head and neck cancer, monochemotherapy retains a valuable role in managing patients with advanced disease" 09/01/1986 - "This report concerns the design and results of a randomized prospective trial (SECOG 1) in the treatment of advanced Stage III and IV head and neck cancer with radical radiotherapy combined with polychemotherapy" 11/01/1979 - "These results indicate that this intensive combination chemotherapy has a sufficiently favorable risk/benefit ratio to allow its evaluation in randomized clinical trials in patients with head and neck cancer." 06/01/2008 - "OBJECTIVE: To investigate the prognostic value of the pre-treatment haemoglobin level in patients with advanced squamous cell head and neck cancer treated with induction polychemotherapy" 06/01/2008 - "Pre-treatment haemoglobin level predicts response and survival after TPF induction polychemotherapy in advanced head and neck cancer patients." Order ALL the reference details at left...
3.	Neck Dissection (Radical Neck Dissection) 02/01/1975 - "It is suggested that the last major improvement in the surgical treatment of head and neck cancer was Crile's description of radical neck dissection in 1906, and that modifications of this procedure, including extended surgery, have made little or no difference to survival rates" 11/01/2008 - "BACKGROUND: Selective neck dissection as a part of an elective or therapeutic treatment of the neck is a common practice during the surgical treatment of patients with head and neck cancer" 05/01/2008 - "CONCLUSIONS: Neck dissection is a safe and effective procedure and a necessary component of the multimodality management of all head and neck cancer patients with N2-3 disease" 01/01/2004 - "SLNBX shows promise in its ability to accurately stage NO head and neck cancer and may allow patients with no micro metastatic disease to avoid neck dissection" 06/01/1999 - "Efficacy of targeted chemoradiation and planned selective neck dissection to control bulky nodal disease in advanced head and neck cancer." Order ALL the reference details at left...
4.	Lasers (Laser) 07/01/2007 - "There is increasing evidence that, for some patients, image-guided intensity-modulated radiation therapy (IMRT) for head-and-neck cancer patients may maintain target dose coverage and critical organ (e.g., parotids) dose closer to the planned doses than setup using lasers alone" 02/01/2002 - "Analysis of minimal sample volumes from head and neck cancer by laser scanning cytometry." 11/01/1995 - "The laser technique, new biocompatible implants for the reconstruction of postoperative defects and progress in radiotherapy complete the classic management of head and neck cancer." 01/01/1994 - "Clinical outcome, including operative time, blood loss, and hospital and ICU stay using the Nd:YAG contact laser in curative operations on previously irradiated patients with head and neck cancer, is equal to that of conventional surgical techniques, with or without preoperative radiotherapy.(ABSTRACT TRUNCATED AT 250 WORDS)" 01/01/1989 - "Laser technology in the diagnosis and treatment of head and neck cancer." Order ALL the reference details at left...
5.	Chemoprevention 12/01/2006 - "EXPERIMENTAL DESIGN: We conducted a nested case-control study within a randomized, placebo-controlled chemoprevention trial in patients with early-stage head and neck cancer" 04/06/2005 - "METHODS: We conducted a multicenter, double-blind, placebo-controlled, randomized chemoprevention trial among 540 patients with stage I or II head and neck cancer treated by radiation therapy between October 1, 1994, and June 6, 2000" 06/15/2004 - "Early results of bioadjuvant trials in head and neck cancer suggest that combination chemoprevention will ultimately be an important option." 11/01/1997 - "CONCLUSIONS: These results provide a basis for continuing international collaborative efforts in conducting population-based chemoprevention trials against head and neck cancer." 06/01/1997 - "This study describes the outcomes of an eight-week placebo run-in period in a head and neck cancer chemoprevention trial" Order ALL the reference details at left...

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