Sodium selenite promotes neurological function recovery after spinal cord injury by inhibiting ferroptosis.

Abstract

Ferroptosis is a recently discovered form of iron-dependent cell death, which occurs during the pathological process of various central nervous system diseases or injuries, including secondary spinal cord injury. Selenium has been shown to promote neurological function recovery after cerebral hemorrhage by inhibiting ferroptosis. However, whether selenium can promote neurological function recovery after spinal cord injury as well as the underlying mechanism remain poorly understood. In this study, we injected sodium selenite (3 µL, 2.5 µM) into the injury site of a rat model of T10 vertebral contusion injury 10 minutes after spinal cord injury modeling. We found that sodium selenite treatment greatly decreased iron concentration and levels of the lipid peroxidation products malondialdehyde and 4-hydroxynonenal. Furthermore, sodium selenite increased the protein and mRNA expression of specificity protein 1 and glutathione peroxidase 4, promoted the survival of neurons and oligodendrocytes, inhibited the proliferation of astrocytes, and promoted the recovery of locomotive function of rats with spinal cord injury. These findings suggest that sodium selenite can improve the locomotive function of rats with spinal cord injury possibly through the inhibition of ferroptosis via the specificity protein 1/glutathione peroxidase 4 pathway.

• Authors: Yi-Xin Chen, Talifu Zuliyaer, Bin Liu, Shuang Guo, De-Gang Yang, Feng Gao, Yan Yu, Ming-Liang Yang, Liang-Jie Du, Jian-Jun Li
• Journal: Neural regeneration research (Neural Regen Res) Vol. 17 Issue 12 Pg. 2702-2709 (Dec 2022) ISSN: 1673-5374 [Print] India
• PMID: 35662217 (Publication Type: Journal Article)