Brain-derived Neurotrophic Factor and Its Applications through Nanosystem Delivery.

Abstract

Brain-derived neurotrophic factor (BDNF) is a protein that performs a neurotrophic function. BDNF and its receptors are widely expressed in the nervous system and can promote the growth of neurons and the formation of neuronal synapses in the brain. Studies have shown that a lack of BDNF can lead to impairment of memory and cognitive functions, indicating that BDNF plays an important role in mental illness and neurodegenerative diseases. The combination of stem cells and BDNF-releasing nanomaterials holds great promise in regenerative medicine, especially in the treatment of neurological diseases. For example, Alzheimer's disease, depression, Parkinson's disease, spinal cord injury, etc. The combination of stem cell/pharmacologically active carrier and BDNF-nano/hydrogel provided a useful new type of local delivery tool for the treatment of the nervous system and other diseases. It can not only provide BDNF but also stem cells. These studies will provide a scientific basis for the development and application of BDNF in the future.

• Authors: Mengyao Xia, Tingting Zhao, Xiaolong Wang, Yang Li, Yanling Li, Tingting Zheng, Jiaxin Li, Yu Feng, Yongli Wei, Peng Sun
• Journal: Iranian journal of pharmaceutical research : IJPR (Iran J Pharm Res) Vol. 20 Issue 4 Pg. 137-151 ( 2021) ISSN: 1735-0328 [Print] Netherlands
• PMID: 35194435 (Publication Type: Journal Article, Review)