Abstract | INTRODUCTION: METHODS: Terminally anaesthetised minipigs (groups n = 5) were exposed to sham bronchoscopy or given mixtures (0.5 mL/kg) of: saline, GJ, OP insecticide and GJ (OP + GJ), or Solv and GJ (Solv + GJ), placed into the right lung, and monitored for 48 h. Lung injury was assessed through analysis of bronchoalveolar lavage fluid (BALF), computed tomography and histopathology. RESULTS: OP + GJ created a direct lung injury consisting of neutrophil infiltration, oedema and haemorrhage, as well as indirect injury to the other lung. OP + GJ directly-injured lung parenchyma had increased concentrations of BALF protein, albumin, IL-6, IL-8 and C-reactive protein (CRP) at 24 h (p < 0.05), and BALF protein, albumin and CRP at 48 h (p < 0.05), when compared with controls. Aspiration of GJ produced similar direct effects to OP + GJ but less indirect lung injury. Lung injury was less severe after Solv + GJ, for combined lung histopathology scores (vs. OP + GJ, p < 0.05) and for the proportion of directly-injured lung that was poorly/non-aerated at 48 h. CONCLUSION: Pulmonary instillation of OP + GJ created more lung damage than controls or Solv + GJ. In patients with severe OP insecticide poisoning and reduced consciousness, early airway protection is likely to reduce pulmonary damage.
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Authors | Elspeth J Hulse, Richard E Clutton, Gordon Drummond, Adrian P Thompson, Edwin J R van Beek, Sionagh H Smith, Michael Eddleston |
Journal | Clinical toxicology (Philadelphia, Pa.)
(Clin Toxicol (Phila))
Vol. 60
Issue 6
Pg. 725-736
(06 2022)
ISSN: 1556-9519 [Electronic] England |
PMID | 35147477
(Publication Type: Journal Article)
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Chemical References |
- Albumins
- Insecticides
- Organophosphorus Compounds
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Topics |
- Albumins
- Animals
- Bronchoalveolar Lavage Fluid
- Gastrointestinal Contents
- Humans
- Insecticides
(toxicity)
- Lung
- Lung Injury
(chemically induced)
- Organophosphate Poisoning
- Organophosphorus Compounds
- Swine
- Swine, Miniature
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