Abstract | AIM: METHODS: RESULTS: Alpha and β tubulins were the most abundant clozapine- binding proteins. We also found that clozapine directly binds with α and β tubulin heterodimers to inhibit their polymerization to form microtubules and disturbs the microtubule network, causing mitotic arrest in HeLa cells. CONCLUSION: These results suggest that α and β tubulin heterodimers are targeted by the clozapine and the microtubules are involved in the etiology of schizophrenia.
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Authors | Mizuki Hino, Takeshi Kondo, Yasuto Kunii, Junya Matsumoto, Akira Wada, Shin-Ichi Niwa, Mitsutoshi Setou, Hirooki Yabe |
Journal | Neuropsychopharmacology reports
(Neuropsychopharmacol Rep)
Vol. 42
Issue 1
Pg. 32-41
(03 2022)
ISSN: 2574-173X [Electronic] United States |
PMID | 34964309
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology. |
Chemical References |
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Topics |
- Animals
- Chromatography, Liquid
- Clozapine
(pharmacology)
- HeLa Cells
- Humans
- Mice
- Mice, Inbred ICR
- Microtubules
(metabolism)
- Tandem Mass Spectrometry
- Tubulin
(chemistry, metabolism, pharmacology)
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