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Tubulin

A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.
Also Known As:
alpha-Tubulin; beta-Tubulin; delta-Tubulin; epsilon-Tubulin; gamma-Tubulin; alpha Tubulin; beta Tubulin; delta Tubulin; epsilon Tubulin; gamma Tubulin
Networked: 4084 relevant articles (98 outcomes, 433 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hamel, Ernest: 60 articles (06/2022 - 10/2002)
2. Kavallaris, Maria: 25 articles (01/2022 - 09/2002)
3. Panda, Dulal: 24 articles (07/2022 - 10/2002)
4. Tuszynski, Jack A: 22 articles (10/2022 - 01/2009)
5. Pinney, Kevin G: 21 articles (09/2021 - 05/2003)
6. Li, Wei: 20 articles (01/2022 - 01/2011)
7. Dumontet, Charles: 20 articles (10/2012 - 12/2002)
8. Brancale, Andrea: 19 articles (06/2022 - 12/2004)
9. Romagnoli, Romeo: 19 articles (06/2022 - 05/2007)
10. Trawick, Mary Lynn: 18 articles (09/2021 - 05/2006)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
4. Infections
05/01/2015 - "These positive findings, showing absence of elevated frequencies of BZ-resistance-associated β-tubulin alleles, have considerable significance since it suggests that farmers can still rely on the efficacy of this important drug class when used for controlling trichostrongyle infections in cattle in Nigeria. "
03/01/2019 - "The data suggest that both the developed PCR methods targeting β-tubulin gene could be used effectively in quarantine process at seed centres for early detection of microsporidian infection in silkworms."
01/25/2008 - "Thus, the immunization of goldfish with recombinant parasite beta-tubulin conferred partial antibody-mediated protection against a challenge infection with live trypanosomes. "
01/25/2008 - "Administration of recombinant parasite beta-tubulin to goldfish (Carassius auratus L.) confers partial protection against challenge infection with Trypanosoma danilewskyi Laveran and Mesnil, 1904."
06/01/2019 - "In the present study, we show (1) by docking analyses that TgGRA8I may interact with both Toxoplasma β-tubulin and actin; (2) by immunoelectron microscopy, proteomic, biochemical, and cellular approaches that TgGRA8I associates with sub-pellicular microtubules and actin at the parasite sub-pellicular cytoskeleton; (3) that type I parasites (RH strain) lacking the GRA8 gene (RHΔku80Δgra8) exhibit loss of conoid extrusion, diminished cell infection, and egress capabilities, and that these motility impairments were likely due to important alterations in their sub-pellicular cytoskeleton, in particular their sub-pellicular microtubules and meshwork. "
5. Carcinoma (Carcinomatosis)

Related Drugs and Biologics

1. Paclitaxel (Taxol)
2. benzimidazole
3. Proteins (Proteins, Gene)
4. taxane
5. Member 1 Subfamily B ATP Binding Cassette Transporter
6. Colchicine
7. Anthelmintics
8. Type II DNA Topoisomerases (Topoisomerase II)
9. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10. Vinca Alkaloids

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Neoadjuvant Therapy
4. Adjuvant Chemotherapy
5. Immunotherapy