Abstract | BACKGROUND: METHODS: Patients with locally advanced NPC were randomly assigned to either a THD group or a control group. All 160 patients received radical intensity-modulated radiotherapy plus cisplatin-based concurrent chemotherapy and basic oral hygiene guidance. Patients in the THD group received additional THD at the beginning of CCRT. The primary end points were the latency period and the incidence of OM. The secondary end points were mouth and throat soreness (MTS), weight loss, short-term efficacy, and adverse events. RESULTS: The median latency period of OM was 30 and 14 days in the THD and control groups, respectively (hazard ratio, 0.32; 95% confidence interval, 0.23-0.35; P < .0001). The incidence of OM and severe OM (World Health Organization grade 3 or higher) was significantly lower in the THD group than the control group (87.5% vs 97.5% [P = .016] and 27.5% vs 46.3% [P = .014], respectively). THD treatment also remarkably reduced the intensity of MTS and the degree of weight loss. In comparison with the control group, the incidence of nausea, vomiting, and insomnia was significantly decreased, whereas the incidence of dizziness and constipation was obviously increased in the THD group. The objective response rates 3 months after CCRT were similar between the groups. CONCLUSIONS: THD prolonged the latency period, reduced the incidence of OM, and did not affect the short-term efficacy of CCRT in patients with NPC. LAY SUMMARY:
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Authors | Leifeng Liang, Zhibing Liu, Haisheng Zhu, Hongqian Wang, Yan Wei, Xuejian Ning, Zhiling Shi, Liujun Jiang, Zhan Lin, Haolin Yan, Rensheng Wang, Kai Hu |
Journal | Cancer
(Cancer)
Vol. 128
Issue 7
Pg. 1467-1474
(Apr 01 2022)
ISSN: 1097-0142 [Electronic] United States |
PMID | 34910297
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 American Cancer Society. |
Chemical References |
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
- Chemoradiotherapy
(adverse effects, methods)
- Cisplatin
- Humans
- Nasopharyngeal Carcinoma
(pathology)
- Nasopharyngeal Neoplasms
(drug therapy, radiotherapy)
- Quality of Life
- Stomatitis
(etiology, prevention & control)
- Thalidomide
(adverse effects)
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