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Thalidomide (Thalomid)

A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
Also Known As:
Thalomid; Sedoval; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-
Networked: 4688 relevant articles (744 outcomes, 933 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Palumbo, Antonio: 62 articles (08/2020 - 01/2004)
2. Anderson, Kenneth C: 40 articles (01/2021 - 04/2002)
3. Boccadoro, Mario: 35 articles (12/2021 - 01/2004)
4. Cavo, Michele: 34 articles (12/2021 - 03/2002)
5. Sonneveld, Pieter: 34 articles (10/2021 - 01/2008)
6. Figg, William D: 32 articles (01/2018 - 02/2002)
7. Facon, Thierry: 29 articles (10/2021 - 01/2002)
8. Musto, Pellegrino: 28 articles (12/2021 - 04/2002)
9. Rajkumar, S Vincent: 28 articles (09/2015 - 11/2002)
10. Offidani, Massimo: 26 articles (10/2022 - 12/2003)

Related Diseases

1. Multiple Myeloma
2. Neoplasms (Cancer)
3. Crohn Disease (Crohn's Disease)
4. Erythema Nodosum
5. Leprosy (Hansen's Disease)

Related Drugs and Biologics

1. Bortezomib (Velcade)
2. Lenalidomide (CC 5013)
3. Dexamethasone (Maxidex)
4. Immunomodulating Agents
5. Prednisone (Sone)
6. Cyclophosphamide (Cytoxan)
7. Melphalan (Alkeran)
8. Proteasome Inhibitors
9. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10. pomalidomide

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Stem Cell Transplantation
4. Radiotherapy
5. Aftercare (After-Treatment)