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Constipation

Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.
Also Known As:
Colonic Inertia; Dyschezia
Networked: 10417 relevant articles (1228 outcomes, 1664 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
2. Pain (Aches)
3. Nausea
4. Diarrhea
5. Vomiting

Experts

1. Camilleri, Michael: 75 articles (05/2022 - 10/2004)
2. Chey, William D: 48 articles (05/2022 - 08/2002)
3. Benninga, Marc A: 36 articles (01/2022 - 07/2006)
4. Camilleri, M: 36 articles (06/2018 - 01/2000)
5. Tack, Jan: 35 articles (10/2022 - 08/2002)
6. Rao, Satish S C: 35 articles (01/2022 - 06/2003)
7. Li, Ning: 34 articles (01/2022 - 03/2007)
8. Di Lorenzo, Carlo: 27 articles (01/2022 - 04/2002)
9. Southwell, Bridget R: 26 articles (12/2020 - 09/2004)
10. Hwang, Dae Youn: 25 articles (06/2022 - 11/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Constipation:
1. LaxativesIBA
2. Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric
3. prucaloprideIBA
4. tegaserod (Zelnorm)FDA Link
5. Lactulose (Duphalac)FDA LinkGeneric
6. LubiprostoneFDA Link
7. Opioid Analgesics (Opioids)IBA
8. Loperamide (Imodium)FDA LinkGeneric
9. linaclotideIBA
10. Dietary FiberFDA Link

Therapies and Procedures

1. Therapeutics
01/01/2018 - "Constipation was the most commonly improved symptom based on prevalence prior to therapy (noted by 6/20 patients suffering with constipation). "
10/01/2005 - "PEG+E, administered orally at a dose equivalent to eight 13.8 g sachets (1 L) per day over three days, was a highly effective and well tolerated therapy for the treatment of severe constipation and faecal impaction."
01/01/2023 - "Results showed the total effective rate [OR = 3.83, 95% CI (2.71, 5.43), P < 0.01] and quality of life [OR = -9.78, 95% CI (-12.32, -7.23), P < 0.01] effectively improved after TCM external therapy; constipation symptoms [OR = -1.64, 95% CI (-2.31, -0.96), P < 0.01] reduced; defecation time [OR = -0.68, 95% CI (-0.99, -0.37), P < 0.01] shortened and spontaneous complete bowel movements (SCBM) [OR = 0.48, 95% CI (0.01, 0.95), P < 0.05] increased; and recurrence rate [OR = 0.25, 95% CI (0.17, 0.38), P < 0.01] reduced. "
03/01/2022 - "Based on these findings, we propose utilization of stimulant bowel products with proven efficacy as primary therapy after surgery to prevent constipation. "
04/09/2021 - "Overall, compared to laxatives alone, combined therapy of FMT and laxatives more significantly improved total effective rate (risk ratio: 1.35; 95% confidence interval [CI]: 1.14, 1.60; I2 = 13%), Bristol stool form scale score (WMD: 1.04; 95% CI: 0.57, 1.51; I2 = 76%), reduce Wexner score (WMD: -3.25; 95% CI: -5.58, -0.92; I2 = 92%), Knowles-Eccersley-Scott-Symptom (KESS) score (WMD: -5.65; 95% CI: -7.62, -3.69; I2 = 0%) and patient assessment of constipation quality of life score (WMD: -18.56; 95%; CI: -26.43, -10.68; I2 = 78%). "
2. Psychology Biofeedback (Biofeedback)
3. Enema (Enemas)
4. Massage (Zone Therapy)
5. Drug Therapy (Chemotherapy)