Abstract | BACKGROUND: METHODS: RESULTS: The study included 354 patients, 57% male, mean age 73 (SD 11) years, mean observation time 2.5 (SD 0.6) years, and median National Institute of Health Stroke Scale of 0 (IQR 1) at three months. CRP was associated with mortality (HR 1.40, CI 1.01, 1.96, p = 0.046), and neopterin was associated with the combined endpoint (recurrent ischemic stroke or death) (HR 1.52, CI 1.06, 2.20, p = 0.023), adjusted for age, sex, prior cerebrovascular disease, modified Rankin Scale, and creatinine. When adding neopterin and KA to the same model, KA was negatively associated (HR 0.57, CI 0.33, 0.97, p = 0.038), and neopterin was positively associated (HR 1.61, CI 1.02, 2.54, p = 0.040) with mortality. Patients with cardioembolic stroke at baseline had higher levels of inflammation at three months. CONCLUSION:
Neopterin might be a valuable prognostic biomarker in stroke patients. The use of KA as a measure of anti-inflammatory capacity should be investigated further. TRIAL REGISTRATION: The study was registered at Clinicaltrials.gov ( NCT02650531 ). First posted on 08/01/2016.
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Authors | Katinka Nordheim Alme, Arve Ulvik, Torunn Askim, Jörg Assmus, Tom Eirik Mollnes, Mala Naik, Halvor Næss, Ingvild Saltvedt, Per-Magne Ueland, Anne-Brita Knapskog |
Journal | BMC neurology
(BMC Neurol)
Vol. 21
Issue 1
Pg. 476
(Dec 08 2021)
ISSN: 1471-2377 [Electronic] England |
PMID | 34879833
(Publication Type: Journal Article, Multicenter Study)
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Copyright | © 2021. The Author(s). |
Chemical References |
- Biomarkers
- Neopterin
- Kynurenic Acid
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Topics |
- Aged
- Biomarkers
- Brain Ischemia
(complications)
- Cohort Studies
- Female
- Humans
- Inflammation
- Ischemic Stroke
- Kynurenic Acid
- Male
- Neopterin
- Prospective Studies
- Stroke
(complications, diagnosis)
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