Although the original data on systemic oxidative stress in
COVID-19 patients have recently started to emerge, we are still far from a complete profile of changes in patients' redox homeostasis. We aimed to assess the extent of oxidative damage of
proteins,
lipids and
DNA during the course of
acute disease, as well as their association with CT pulmonary patterns. In order to obtain more insight into the origin of the systemic oxidative stress, the observed parameters were correlated with inflammatory
biomarkers and
biomarkers of multiorgan impairment. In this prospective study, we included 58 patients admitted between July and October 2020 with
COVID-19 pneumonia. Significant changes in
malondialdehyde,
8-hydroxy-2'-deoxyguanosine and
advanced oxidation protein products levels exist during the course of
COVID-19. Special emphasis should be placed on the fact that the pattern of changes differs between non-hospitalized and hospitalized individuals. Our results point to the time-dependent relation of oxidative stress parameters with inflammatory and multiorgan impairment
biomarkers, as well as pulmonary patterns in
COVID-19 pneumonia patients. Correlation between redox
biomarkers and immunological or multiorgan impairment
biomarkers, as well as pulmonary CT pattern, confirms the suggested involvement of neutrophils networks,
IL-6 production, along with different organ/tissue involvement in systemic oxidative stress in
COVID-19.