Circulating diazepam-binding inhibitor in infancy: Relation to markers of adiposity and metabolic health.

Abstract

BACKGROUND:

Diazepam-binding inhibitor (DBI) controls feeding behaviour and glucose homeostasis. Individuals born small-for-gestational-age (SGA) with excessive postnatal catch-up in weight are at risk for obesity and type 2 diabetes.

OBJECTIVE:

To assess serum concentrations of DBI (0-2 years) in appropriate-for-gestational-age (AGA, n = 70) vs SGA infants (n = 33) with spontaneous catch-up and their relationship with endocrine-metabolic and adiposity markers.

METHODS:

Longitudinal assessments included auxology, fasting glucose, insulin, insulin-like growth factor, high-molecular-weight adiponectin, DBI and body composition (absorptiometry). DBI was measured cross-sectionally in pregnant and non-pregnant women and in 2-day-old newborns. DBI mRNA expression levels were assessed in adult and neonatal tissues.

RESULTS:

Cord blood DBI concentrations were similar in AGA and SGA newborns and about fivefold higher than those in women. Serum DBI levels decreased by age 2 days, were higher in SGA vs AGA infants at age 2 years and associated negatively with markers of adiposity and insulin resistance and positively with high-molecular-weight adiponectin. DBI mRNA expression was lower in placenta than in other tissues.

CONCLUSION:

The increased DBI concentrations at birth are unrelated to prenatal growth. The higher DBI levels in SGA subjects at age 2 years may be related to catch-up growth or represent an adaptive mechanism to promote lipogenesis.

• Authors: Marta Díaz, Albert Blasco-Roset, Joan Villarroya, Abel López-Bermejo, Francis de Zegher, Francesc Villarroya, Lourdes Ibáñez
• Journal: Pediatric obesity (Pediatr Obes) Vol. 16 Issue 11 Pg. e12802 (11 2021) ISSN: 2047-6310 [Electronic] England
• PMID: 34014038 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2021 World Obesity Federation.

Chemical References

• Diazepam Binding Inhibitor
• Diazepam

Topics

• Adiposity
• Child, Preschool
• Diabetes Mellitus, Type 2
• Diazepam
• Diazepam Binding Inhibitor
• Humans
• Infant, Newborn
• Obesity