Alleviation of the chronic stress response attributed to the antioxidant and anti-inflammatory effects of electrolyzed hydrogen water.

Abstract

Reactive oxygen species (ROS) are highly reactive and directly attack surrounding biomolecules to deteriorate cellular and tissue functions. Meanwhile, ROS also serve as signaling mediators to upregulate pro-inflammatory cytokine expression via activation of the nuclear factor kappa B signaling pathway, and the increased pro-inflammatory cytokines trigger respiratory burst of inflammatory cells that further accelerates ROS production in the inflamed tissue. Such crosstalk between ROS and inflammatory responses leads to a chain reaction of negativity, and cause progression of several chronic pathologies. Since molecular hydrogen is known to preferentially remove cytotoxic hydroxyl radicals and peroxynitrites, and to prevent cell and tissue damage, we here examined whether electrolyzed hydrogen water (EHW) enriched with molecular hydrogen and reactive hydrogen storing platinum nanoparticles dissolved from an electrode could alleviate oxidative stress and inflammation induced by continuous stress challenges. Five-day continuous stress loading to rats elevated reactive oxygen metabolites-derived compounds (d-ROMs), interleukin (IL)-1β, and adrenocorticotropic hormone (ACTH) levels and decreased the biological antioxidant potential (BAP) level. Drinking EHW during 5-day continuous stress loading significantly alleviated all of these changes. The results suggest that EHW could suppress stress-response-associated oxidative stress and IL-1β level elevation in vivo, and that drinking of EHW is effective for controlling stress responses via its antioxidant potential.

• Authors: Di Hu, Danxi Li, Mika Shigeta, Yuta Ochi, Takashi Okauchi, Hiroyuki Neyama, Shigeru Kabayama, Yasuyoshi Watanabe, Yilong Cui
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 535 Pg. 1-5 (01 08 2021) ISSN: 1090-2104 [Electronic] United States
• PMID: 33340760 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Interleukin-18
• Reactive Oxygen Species
• Water
• Hydrogen
• Adrenocorticotropic Hormone

Topics

• Adrenocorticotropic Hormone (blood)
• Animals
• Anti-Inflammatory Agents (pharmacology)
• Antioxidants (pharmacology)
• Electrodes
• Electrolysis
• Hydrogen (administration & dosage, pharmacology)
• Inflammation (blood, drug therapy, metabolism)
• Interleukin-18 (blood)
• Male
• Oxidative Stress (drug effects)
• Rats
• Reactive Oxygen Species (metabolism)
• Water (administration & dosage, pharmacology)