Abstract | BACKGROUND: Conventional prognostic risk factors can only partly explain the adverse clinical outcomes after ischemic stroke. We aimed to establish a set of prognostic metrics and evaluate its public health significance on the burden of adverse clinical outcomes of ischemic stroke. METHODS: All patients were from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). We established prognostic metrics of ischemic stroke from 20 potential biomarkers in a propensity-score-matched extreme case sample (n = 146). Pathway analysis was conducted using Ingenuity Pathway Analysis. In the whole CATIS population (n = 3575), we evaluated effectiveness of these prognostic metrics and estimated their population-attributable fractions (PAFs) related to the risk of clinical outcomes. The primary outcome was a composite outcome of death or major disability (modified Rankin Scale score ≥3) at 3 months after stroke. RESULTS: CONCLUSION:
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Authors | Daoxia Guo, Zhengbao Zhu, Chongke Zhong, Aili Wang, Xuewei Xie, Tan Xu, Yanbo Peng, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Jing Chen, Liping Liu, Yilong Wang, Jiang He, Yonghong Zhang |
Journal | Clinical chemistry
(Clin Chem)
Vol. 66
Issue 11
Pg. 1434-1443
(11 01 2020)
ISSN: 1530-8561 [Electronic] England |
PMID | 33276383
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © American Association for Clinical Chemistry 2020. All rights reserved. For permissions, please email: [email protected]. |
Chemical References |
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Topics |
- Aged
- Atherosclerosis
(blood)
- Biomarkers
(blood)
- Female
- Humans
- Inflammation
(blood)
- Ischemic Stroke
(blood, diagnosis)
- Male
- Middle Aged
- Prognosis
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