Abstract | BACKGROUND: Postoperative neurocognitive disorders may arise in part from adverse effects of general anaesthetics on the CNS, especially in older patients or individuals otherwise vulnerable to neurotoxicity because of systemic disease or the presence of pre-existing neuropathology. Previous studies have documented cytokine and injury biomarker responses to surgical procedures that included general anaesthesia, but it is not clear to what degree anaesthetics contribute to these responses. METHODS: RESULTS: Baseline biomarkers were in the normal range, although NF-L and GFAP were elevated as a function of age. At 5 h after induction of anaesthesia, plasma tau, NF-L, and GFAP were significantly decreased relative to baseline. Plasma IL-6 was significantly increased after anaesthesia, but by a biologically insignificant degree (<1 pg ml-1); plasma TNF-α and CRP were unchanged. CONCLUSIONS:
Sevoflurane general anaesthesia without surgery, even in older adults, did not provoke an inflammatory state or neuronal injury at a concentration that is detectable by an acute elevation of measured plasma biomarkers in the early hours after exposure. CLINICAL TRIAL REGISTRATION: NCT02275026.
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Authors | Stacie Deiner, Mark G Baxter, Joshua S Mincer, Mary Sano, James Hall, Ismail Mohammed, Sid O'Bryant, Henrik Zetterberg, Kaj Blennow, Roderic Eckenhoff |
Journal | British journal of anaesthesia
(Br J Anaesth)
Vol. 125
Issue 3
Pg. 282-290
(09 2020)
ISSN: 1471-6771 [Electronic] England |
PMID | 32536445
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Anesthetics, Inhalation
- Biomarkers
- Glial Fibrillary Acidic Protein
- Interleukin-6
- Neurofilament Proteins
- Tumor Necrosis Factor-alpha
- neurofilament protein L
- C-Reactive Protein
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anesthesia, General
(methods)
- Anesthetics, Inhalation
(blood)
- Biomarkers
(blood)
- C-Reactive Protein
(drug effects)
- Cohort Studies
- Female
- Glial Fibrillary Acidic Protein
(blood, drug effects)
- Healthy Volunteers
- Humans
- Interleukin-6
(blood)
- Male
- Middle Aged
- Neurofilament Proteins
(blood, drug effects)
- Prospective Studies
- Reference Values
- Tumor Necrosis Factor-alpha
(blood, drug effects)
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