Abstract | BACKGROUND: AIM: METHODS: We evaluated plasma levels of sHLA-G and of 13 cytokines using ELISA and flow cytometry, respectively, in PTC patients at two time points: pre- and post- thyroidectomy; and control subjects. RESULTS: Compared with controls, IL-6 levels were increased, while IL-1β, IFN-α and TGF-β1 levels were decreased in pre- thyroidectomy PTC patients. IFN-α and TGF-β1 efficiently discriminated patients from controls and were associated with extrathyroidal extension and lymph node metastasis, respectively. In addition, TNF and IL-13 were associated with male gender, lymph node metastasis and Hashimoto thyroiditis, and sHLA-G with tumour invasion. Compared with pre- thyroidectomy, IL-4, IL-10, TNF, IFN-α and TGF-β1 levels were increased in post- thyroidectomy. CONCLUSION: There are significant changes in the cytokine profile after surgical removal of the thyroid tumour, and IFN-α e TGF-β1 showed to be promising cytokines for discriminating PTC patients from controls. We also found that different cytokines are associated with clinicohistopathological characteristics of PTC related to poor prognosis, suggesting that cytokines seem to play an important role in PTC development and management.
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Authors | Bruna C Bertol, Jéssica N G de Araújo, Ibrahim A Sadissou, Paulin Sonon, Fabrício C Dias, Raul H Bortolin, Nathalie L de Figueiredo-Feitosa, Luiz C Conti de Freitas, Sheila R de Miranda Henrique Tarrapp, Carlos C de Oliveira Ramos, André D Luchessi, Janaina C O C de Freitas, Léa M Z Maciel, Vivian N Silbiger, Eduardo A Donadi |
Journal | International journal of clinical practice
(Int J Clin Pract)
Vol. 74
Issue 10
Pg. e13585
(Oct 2020)
ISSN: 1742-1241 [Electronic] India |
PMID | 32534476
(Publication Type: Journal Article)
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Copyright | © 2020 John Wiley & Sons Ltd. |
Chemical References |
- Biomarkers
- Cytokines
- HLA-G Antigens
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Topics |
- Adult
- Biomarkers
(metabolism)
- Carcinoma, Papillary
(metabolism, pathology, surgery)
- Case-Control Studies
- Cytokines
(blood)
- Female
- HLA-G Antigens
(blood)
- Humans
- Male
- Middle Aged
- Prognosis
- Retrospective Studies
- Thyroid Cancer, Papillary
(metabolism, pathology, surgery)
- Thyroidectomy
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