Hashimoto Disease (Thyroiditis, Hashimoto)

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415 relevant articles (8 outcomes, 25 trials/studies) found for this Disease

Description: Chronic autoimmune thyroiditis, characterized by the presence of high serum thyroid AUTOANTIBODIES; GOITER; and HYPOTHYROIDISM.

Also Known As:

Thyroiditis, Hashimoto; Hashimotos Disease; Hashimoto's Disease; Chronic Lymphocytic Thyroiditis; Hashimoto Thyroiditis; Chronic Lymphocytic Thyroiditides; Disease, Hashimoto; Disease, Hashimoto's; Hashimoto Thyroiditides; Lymphocytic Thyroiditides, Chronic; Lymphocytic Thyroiditis, Chronic; Thyroiditides, Chronic Lymphocytic; Thyroiditides, Hashimoto; Thyroiditis, Chronic Lymphocytic

Relationship Network

Disease Context: Research Results

Endocrine System Diseases: 398

Thyroid Diseases: 3109

Thyroiditis: 2095

Autoimmune Thyroiditis: 1086

Hashimoto Disease: 415

Related Diseases

1.	Graves Disease (Basedow Disease)
2.	Hypothyroidism
3.	Thyroid Diseases (Thyroid Disease)
4.	Diabetes Mellitus
5.	Thyrotoxicosis

Experts

1.	Watanabe, Mikio: 3 articles (03/2008 - 09/2002)
2.	Iwatani, Yoshinori: 3 articles (03/2008 - 09/2002)
3.	Lewiński, Andrzej: 2 articles (06/2003 - 08/2002)
4.	Karbownik, Małgorzata: 2 articles (06/2003 - 08/2002)
5.	Zasada, Krzysztof: 2 articles (06/2003 - 08/2002)
6.	Shabb, Nina S: 1 article (09/2008)
7.	Szodoray, Peter: 1 article (09/2008)
8.	Horvath, Ildiko: 1 article (09/2008)
9.	Salti, Ibrahim S: 1 article (09/2008)
10.	Zhang, De-Liang: 1 article (09/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hashimoto Disease:

1.	AntibodiesIBA 01/01/1988 - "These studies show that lymphocytes capable of producing antithyroid antibodies can be present in the thyroid glands of patients with Hashimoto disease without evidence of a peripheral immune response, thus indicating that Hashimoto disease can exist as an organ-restricted autoimmune disorder." 08/11/2008 - "Independent risk factors for events were baseline findings for TSH and TPO antibodies in a level-dependent relationship (for TSH the risk already starts to increase at values >2.0 mIU/L) and family background (with the greatest risk attached to subjects having 2 relatives with Hashimoto disease). " 10/01/2005 - "DISCUSSION: Hashimoto encephalopathy is a rare autoimmune condition that occurs in patients with Hashimoto thyroiditis and high titers of antithyroid antibodies. " 12/22/2004 - "The diagnosis of Hashimoto disease was based on the high titers of anti-thyroid antibodies and histological findings. " 01/19/2002 - "CONCLUSION: When faced with signs evoking OATD, these data emphasize the need for an evaluation of thyroid status and determination of the antibodies implied in Basedow and Hashimoto's disease. " Order ALL the reference details at left...
2.	Thyrotropin Receptors (Thyrotropin Receptor)IBA 10/01/1996 - "RESULTS: TSH receptor transcript levels were higher in Graves' disease than in Hashimoto's disease and healthy control. " 04/01/1998 - "RESULTS: TSH receptor Abs were detected by bioassay in 10 (91%) of 11 patients with active Graves disease but in 0 of 2 patients in remission, 0 of 13 normal members of the control group, and 0 of 11 patients with chronic lymphocytic thyroiditis including 1 with thyrotoxicosis. " 05/01/1986 - "The assay detected TSH receptor antibodies in 81 of 85 patients (95%) with untreated Graves' disease, no patients with Graves' disease in remission, and 7 of 57 patients (12%) with Hashimoto's disease. " 12/01/2009 - "Diagnosis and discrimination of autoimmune Graves' disease and Hashimoto's disease using thyroid-stimulating hormone receptor-containing recombinant proteoliposomes." 02/01/2003 - "The role of stimulating, function-blocking and growth-blocking anti-TSH receptor antibodies (TRAbs) in GD, Hashimoto's disease and in atrophic thyroiditis." Order ALL the reference details at left...
3.	Thyroxine (Levothyroxine)FDA LinkGeneric 01/01/1998 - "This study investigated the effectiveness of L-thyroxine management in 32 patients (mean age 11 years and 2 months; M:F = 1:5) with Hashimoto's disease followed annually for 3 years. " 08/01/2006 - "OBJECTIVE: To investigate the potential association between serum inflammatory cytokine levels and thyroxine replacement dose in patients with Hashimoto disease. " 04/01/1999 - "The clinical diagnosis of Hashimoto's disease was confirmed by aspiration biopsy of the mass during the course of L-thyroxine treatment. " 01/01/1998 - "Patients with Hashimoto's disease treated with L-thyroxine and followed for three years." 03/29/1996 - "HISTORY AND CLINICAL FINDINGS: For 4 months a 37-year-old woman had been treated for Hashimoto thyroiditis with L-thyroxine, at first 25, then 50 micrograms. " Order ALL the reference details at left...
4.	HormonesIBA 10/01/1997 - "Therefore, scintigraphy, ultrasonography and serum thyroid hormone estimation alone may not be helpful for the final diagnosis of Hashimoto's disease. " 08/01/2009 - "CONCLUSION: The D2-Thr92Ala polymorphism is not associated with thyroid hormone levels or T4 dose in patients treated for DTC or Hashimoto thyroiditis." 05/01/2009 - "Furthermore, the casual association of TSH-As with Hashimoto thyroiditis may led to an adjunctive delay in diagnosis, because of low thyroid hormone levels." 04/01/1994 - "The effect of thyroid hormone treatment on thyromegaly was evaluated in 69 patients < or = 18 years of age with goitrous Hashimoto disease. " 04/01/1994 - "Effect of thyroid hormone treatment on thyromegaly in children and adolescents with Hashimoto disease." Order ALL the reference details at left...
5.	Thyroglobulin FDA Link 01/01/2009 - "Hashimoto thyroiditis can be partially reproduced in mice by immunization with thyroglobulin or, more recently, thyroperoxidase. " 10/01/1999 - "In our investigations, we have shown directly that T cells from humans with chronic lymphocytic thyroiditis proliferate in the presence of iodinated but not in the presence of noniodinated human thyroglobulin. " 08/01/1984 - "Here, circulating 5/9+ and 5/9- T lymphocytes were isolated from patients with Hashimoto's disease, and the proliferative response induced by human thyroglobulin was investigated. " 10/01/1979 - "The relative number of thyroglobulin-binding circulating lymphocytes was elevated in six subjects with Hashimoto's disease. " 05/21/1960 - "Human foetal thyroglobulin with particular reference to the aetiology of Hashimoto's disease." Order ALL the reference details at left...
6.	Immunoglobulin G (IgG)IBA 08/01/1989 - "Both titre and affinity of IgG3 and IgG2 anti-Tg were generally low but in some Hashimoto's disease patients high-affinity IgG2 anti-Tg were found and IgG2 anti-Tg, unlike those of other subclasses, showed very restricted heterogeneity. " 11/01/1990 - "This IgG may be involved in the mechanism that causes hypothyroidism in some patients with goitrous Hashimoto's disease." 06/01/1986 - "To the Triton-solubilized FCM crosslinked with 125I-TSH, 50 micrograms each of IgG from 20 normal controls, 20 patients with Graves' disease and 20 with Hashimoto's disease was added and precipitation was effected by adding anti-human IgG. In patients with Graves' disease, 125I-TSH-FCM complexes immunoprecipitated ranged from 1.10 to 4.18% with an average of 2.4 +/- 0.99 (S. " 01/01/1986 - "IgG from 2 hypothyroid patients with Hashimoto's disease, which were strongly positive in the TSH binding inhibition (TBI) assay, yielded FBI values within the range in Graves' disease, but values in TBI-negative IgG from 15 other patients with Hashimoto's disease were normal (0.0 +/- 0.9). " 08/01/1989 - "In contrast, a progressive increase in IgG1 anti-Tg affinity was seen in clinically euthyroid individuals compared with their relatives with thyroid disease and high titred Hashimoto's disease patients, suggesting that either rising titres of high affinity IgG1 anti-Tg or affinity maturation of IgG1 anti-Tg may be indicative of impending hypothyroidism." Order ALL the reference details at left...
7.	HLA-DR Antigens (HLA-DR)IBA 09/01/1989 - "Intrathyroidal HLA-DR-positive lymphocytes in Hashimoto's disease: increases in CD8 and Leu7 cells." 11/01/1986 - "Aberrant expression of HLA-DR antigens on epithelial cells is seen in various organ-specific autoimmune disorders including Hashimoto thyroiditis (HT). " 02/01/1985 - "Normal thyroid epithelial cells did not express HLA-DR. Only a few epithelial cells in the vicinity of lymphoid infiltrations were HLA-DR+ in early stages of Hashimoto thyroiditis, and the number of HLA-DR+ epithelial cells was significantly increased in advanced stages of the disease. " 05/01/1996 - "The number of HLA-DR positive thyroid cells was significantly greater in Hashimoto thyroiditis than in Graves disease. " 05/01/1996 - "Normal thyroid cells did not express HLA-DR antigens, but HLA-DR antigens were often found in some thyroid cells from patients with Hashimoto thyroiditis or with Graves disease. " Order ALL the reference details at left...
8.	Insulin ReceptorIBA 01/01/1986 - "Positive results were also obtained in sera from 2 patients with TBI-positive Hashimoto's disease and 2 with diabetes mellitus associated with anti-insulin receptor antibodies (type B diabetes mellitus). " 03/01/1988 - "To determine the presence and potential importance of a more generalized deregulation of immune response in patients with Grave's disease and Hashimoto's disease, sera from 33 patients with Graves' disease and 16 patients with Hashimoto's disease were screened for the presence of anti-insulin antibodies and anti-insulin-receptor antibodies. " Order ALL the reference details at left...
9.	CortisoneIBA 10/01/1987 - "Possible pathogenetic mechanisms of cortisone-induced remission of hypothyroidism due to chronic lymphocytic thyroiditis are discussed." Order ALL the reference details at left...
10.	Factor IX (PTC)FDA LinkGeneric 06/01/2007 - "The case that was cytologically upgraded was a follicular variant of PTC in Hashimoto thyroiditis with a focus of tall cells. " 10/01/2001 - "Our group has previously demonstrated an association between Hashimoto thyroiditis and ret/PTC-1 activation, and have hypothesised that c-ret activation might be implicated in immune reaction to thyroid epithelium. " 10/01/2005 - "Several studies report a higher rate of papillary thyroid carcinomas (PTC) in patients with Hashimoto thyroiditis (HT), indicating a possible correlation between the two diseases. " 01/01/2002 - "The occurrence of RET/PTC in Hashimoto thyroiditis and thyroid follicular adenomas and hyperplastic nodules reported in several studies has not been confirmed in other observations and remains controversial." 10/01/2009 - "OBJECTIVE: The effect of coexistent chronic lymphocytic thyroiditis (CLT) on prognosis in papillary thyroid carcinoma (PTC) patients remains controversial. " Order ALL the reference details at left...

Therapies and Procedures

1.	Thyroidectomy 11/01/1988 - "Twenty-one cases were selected from 236 thyroidectomies with a diagnosis of Hashimoto's disease for detailed clinicopathologic study on the basis of "early" changes in three cases and an unusually heavy lymphoplasmacytic infiltrate in 18 cases. " 08/01/1976 - "The Authors describe a case, which came under their observation, of indifferentiated neoplasia of the thyroid associated with Hashimoto's disease; treated surgically by total thyroidectomy, at a distance of over four years it did not show signs of recurrence. " 12/01/1954 - "Thyroidectomy for struma lymphomatosa; Hashimoto's disease." 07/01/1991 - "The results of thyroid function and autoimmune tests were compatible with a diagnosis of Hashimoto's disease and thus, total thyroidectomy with a tracheostomy was performed uneventfully. " 06/01/2008 - "Histopathology of the tissue from a thyroidectomy revealed papillary thyroid carcinoma in the right lobe and chronic lymphocytic thyroiditis in the remaining tissue. " Order ALL the reference details at left...
2.	Lasers (Laser) 01/01/2009 - "PATIENT AND METHODS: We report a case of a minute focus of primary extranodal marginal zone B-cell lymphoma (EMZBCL), incidentally discovered in a 63-year-old man with Hashimoto thyroiditis (HT) and diagnosed by means of polymerase chain reaction (PCR) after laser capture microdissection.The" 01/01/2009 - "A minute focus of extranodal marginal zone B-cell lymphoma arising in Hashimoto thyroiditis diagnosed with PCR after laser capture microdissection: a case report." 10/01/2001 - "The objective of this study was to examine expression of the cellular adhesion molecule, E-cadherin, in various thyroid tumor types and Hashimoto thyroiditis in the context of ret/PTC-1 positivity by using laser capture microdissection and TaqMan reverse transcription-polymerase chain reaction (RT-PCR). " Order ALL the reference details at left...
3.	Thymectomy 02/01/1991 - "[A case report of extended thymectomy in an elderly patient with myasthenia gravis associated with Hashimoto's disease]" 12/01/1964 - "IMMUNOLOGICAL DISTURBANCES IN MYASTHENIA GRAVIS WITH A REPORT OF HASHIMOTO'S DISEASE DEVELOPING AFTER THYMECTOMY." Order ALL the reference details at left...
4.	Drug Therapy (Chemotherapy) 03/01/2001 - "Further investigation concerning the mechanisms involved and the possible effects of antibacterial chemotherapy on the outcome of Hashimoto's disease is warranted." 10/01/2002 - "For example, consider the milestones of development, such as puberty or menopause, the unique differences in the prevalence of autoimmune diseases and disorders (Sjögren's syndrome, Hashimoto's disease), differences in the onset and progression of osteoporosis and osteoarthritis, differences in response to radiation and chemotherapy, and the differences in chronic facial pain, chronic fatigue syndrome, and fibromyalgia. " Order ALL the reference details at left...
5.	Investigational Therapies (Experimental Therapy) 01/01/2008 - "MATERIALS AND METHODS: Six cases are described: case 1, a 59-year-old woman with hyperstimulation and intramuscular fibroids compressing the uterine cavity who wanted to be a donor egg recipient; case 2, a 59-year-old woman desiring a second transfer of sibling frozen embryos who had previously conceived with donor eggs at age 57; case 3, a 33-year-old woman with a subseptated uterus and cervical abnormality from intrauterine diethilstibesterol exposure plus hemoaphilia trait, and only 25% of her liver remaining from a previous partial liver resection; case 4, a woman with an unicornuate uterus refusing reduction of her twins to a singleton; case 5, a 39-year-old woman willing to try again to have her first live born child with a history of a large macroprolactinoma that was resected but markedly enlarged in her previous pregnancy despite bromocryptine therapy; and, case 6, a woman willing to try a unique experimental therapy with extremely high thyroid stimulating immunoglobulins to inhibit severe intrauterine growth retardation and potential premature synostosis for her condition of Hashimoto's disease. " Order ALL the reference details at left...

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