Injured somatosensory nervous system cause
neuropathic pain which is quite difficult to treat using current approaches. It is therefore important to find new therapeutic options. We have analyzed
cedrol effect on chronic constriction injury (CCI) induced
neuropathic pain in rats. The mechanical and thermal
hypersensitivity were evaluated using the von Frey filament, radiant heat and
acetone drop methods. The changes in the levels of
biomarkers of oxidative stress including
malondialdehyde (MDA) and total
thiol (SH), as well as inflammatory mediators including Tumour
Necrosis Factor alpha (TNF-α) and
Interleukin 6 (IL-6) were estimated in the lumbar portion (L4-L6) of neuropathic rats. Administration of
cedrol attenuated the CCI-induced mechanical and thermal
hypersensitivity. CCI produced an increase in MDA along with a reduction in SH levels in the spinal cord of the CCI rats. Reduced levels of SH were restored by
cedrol. Also, the levels of MDA were reduced in the
cedrol-treated CCI rats compared to the untreated CCI rats. Besides, level of TNF-α and
IL-6 increased in the spinal cord of CCI group and
cedrol could reverse it. The current study showed that
cedrol attenuates
neuropathic pain in CCI rats by inhibition of inflammatory response and attenuation of oxidative stress.