Taurine and hesperidin rescues carbon tetrachloride-triggered testicular and kidney damage in rats via modulating oxidative stress and inflammation.

Abstract

AIMS:

This study assessed the prophylactic or therapeutic effects of taurine (TR) and/or hesperidin (HES) on carbon tetrachloride (CCl4) induced acute kidney and testicular injury in rats.

MAIN METHODS:

Rats were randomly divided into nine experimental groups including control; corn oil; CCl4; HES/CCl4; TR/CCl4; HES + TR/CCl4; CCl4/HES; CCl4/TR; and CCl4/HES + TR groups. CCl4 was intraperitoneally injected with a single dose of 2 ml /kg b.w. HES and TR were orally gavaged twice weekly 100 mg/kg b.w. for four weeks. Kidney function, inflammatory response, sexual hormones, and oxidative stress indicators were assessed. Histomorphological and immune-histochemical studies of the inflammatory marker nuclear factor kappa (NF-κB) in renal and testicular tissues were performed.

KEY FINDINGS:

The results showed that the TR and/or HES treatment significantly suppressed CCl4 induced rise of urea, uric acid, potassium, and follicle-stimulating hormone levels. However, significant restoration of sodium, testosterone, and luteinizing hormone was apparent in CCl4 exposed rats received HES and/or TR. Also, the HES and/or TR treatment significantly rescues CCl4 induced oxidative stress and inflammation. Moreover, the HES and/or TR dosing significantly repaired the CCl4 evoked altered renal and testicular architecture and suppressed NF-κB immunoexpression. Notably, alleviating CCl4 induced renal and testicular damage was more effective in the prophylactic groups than the therapeutic groups. Also, most of the estimated parameters of the HES + TR group did not significantly vary from those of single TR or HES.

SIGNIFICANCE:

In conclusion, HES or TR could efficiently guard against CCl4 nephro-and reprotoxic effects, but both bioactive combinations afford only a limited synergistic outcome.

• Authors: Yasmina M Abd-Elhakim, Mervat H Ghoneim, Lamiaa L M Ebraheim, Tamer S Imam
• Journal: Life sciences (Life Sci) Vol. 254 Pg. 117782 (Aug 01 2020) ISSN: 1879-0631 [Electronic] Netherlands
• PMID: 32407847 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• NF-kappa B
• Taurine
• Uric Acid
• Testosterone
• Urea
• Luteinizing Hormone
• Follicle Stimulating Hormone
• Sodium
• Carbon Tetrachloride
• Hesperidin
• Potassium

Topics

• Animals
• Carbon Tetrachloride
• Drug Synergism
• Follicle Stimulating Hormone (metabolism)
• Hesperidin (pharmacology)
• Inflammation (prevention & control)
• Kidney (metabolism, pathology)
• Luteinizing Hormone (metabolism)
• Male
• NF-kappa B (metabolism)
• Oxidative Stress (drug effects)
• Potassium (metabolism)
• Rats
• Sodium (metabolism)
• Taurine (pharmacology)
• Testis (metabolism, pathology)
• Testosterone (metabolism)
• Urea (metabolism)
• Uric Acid (metabolism)